Q9Y6M1: Insulin-like growth factor 2 mRNA-binding protein 2

General Information

Protein names	- Insulin-like growth factor 2 mRNA-binding protein 2 - IGF2 mRNA-binding protein 2 - IMP-2 - Hepatocellular carcinoma autoantigen p62 - IGF-II mRNA-binding protein 2 - VICKZ family member 2
Gene names	IGF2BP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y6M1

7 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Insulin-like growth factor 2 mRNA-binding protein 2 - Isoform 3 of Insulin-like growth factor 2 mRNA-binding protein 2 - Isoform 4 of Insulin-like growth factor 2 mRNA-binding protein 2 - Isoform 5 of Insulin-like growth factor 2 mRNA-binding protein 2 - Isoform 6 of Insulin-like growth factor 2 mRNA-binding protein 2

Sequence View

        10         20         30         40         50         60
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
        70         80         90        100        110        120
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
       130        140        150        160        170        180
AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
       190        200        210        220        230        240
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
       250        260        270        280        290        300
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
       310        320        330        340        350        360
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA
       370        380        390        400        410        420
NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH
       430        440        450        460        470        480
HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG
       490        500        510        520        530        540
PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS
       550        560        570        580        590
AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK         10         20         30         40         50         60
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
        70         80         90        100        110        120
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
       130        140        150        160        170        180
AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
       190        200        210        220        230        240
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
       250        260        270        280        290        300
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
       310        320        330        340        350        360
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA
       370        380        390        400        410        420
NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH
       430        440        450        460        470        480
HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG
       490        500        510        520        530        540
PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS
       550        560        570        580        590
AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK         10         20         30         40         50         60
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
        70         80         90        100        110        120
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
       130        140        150        160        170        180
AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
       190        200        210        220        230        240
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
       250        260        270        280        290        300
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
       310        320        330        340        350        360
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA
       370        380        390        400        410        420
NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH
       430        440        450        460        470        480
HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG
       490        500        510        520        530        540
PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS
       550        560        570        580        590
AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK         10         20         30         40         50         60
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
        70         80         90        100        110        120
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
       130        140        150        160        170        180
AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
       190        200        210        220        230        240
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
       250        260        270        280        290        300
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
       310        320        330        340        350        360
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA
       370        380        390        400        410        420
NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH
       430        440        450        460        470        480
HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG
       490        500        510        520        530        540
PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS
       550        560        570        580        590
AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK         10         20         30         40         50         60
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
        70         80         90        100        110        120
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
       130        140        150        160        170        180
AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
       190        200        210        220        230        240
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
       250        260        270        280        290        300
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
       310        320        330        340        350        360
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA
       370        380        390        400        410        420
NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH
       430        440        450        460        470        480
HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG
       490        500        510        520        530        540
PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS
       550        560        570        580        590
AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y6M1-1-unknown	MMNKLY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y6M1-2-acetylation	MNKLYI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y6M1-2-acetylation	MNKLYI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y6M1-2-unknown	MNKLYI...	2		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9Y6M1-69-acetylation	MEVDYS...	69	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9Y6M1-69-acetylation	MEVDYS...	69	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163398
Q9Y6M1-69-unknown	MEVDYS...	69		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77533
Q9Y6M1-377-	GLSVLS...	377			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q9Y6M1-377-unknown	GLSVLS...	377		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177532
Q9Y6M1-377-unknown	GLSVLS...	377		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177534
Q9Y6M1-377-unknown	GLSVLS...	377		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177533

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SQRSK	599	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SQRSK	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73150
...SQRSK	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73151
...SQRSK	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73148
...SQRSK	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73149

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)