TopFIND 4.0

Q9Y6P5: Sestrin-1 {ECO:0000305}

General Information

Protein names
- Sestrin-1 {ECO:0000305}
- 1.11.1.15 {ECO:0000250|UniProtKB:P58004}
- p53-regulated protein PA26 {ECO:0000303|PubMed:9926927}
Gene names SESN1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Y6P5

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRLAAAANEA YTAPLAVSGL LGCKQCGGGR DQDEELGIRI PRPLGQGPSR FIPEKEILQV 
        70         80         90        100        110        120 
GSEDAQMHAL FADSFAALGR LDNITLVMVF HPQYLESFLK TQHYLLQMDG PLPLHYRHYI 
       130        140        150        160        170        180 
GIMAAARHQC SYLVNLHVND FLHVGGDPKW LNGLENAPQK LQNLGELNKV LAHRPWLITK 
       190        200        210        220        230        240 
EHIEGLLKAE EHSWSLAELV HAVVLLTHYH SLASFTFGCG ISPEIHCDGG HTFRPPSVSN 
       250        260        270        280        290        300 
YCICDITNGN HSVDEMPVNS AENVSVSDSF FEVEALMEKM RQLQECRDEE EASQEEMASR 
       310        320        330        340        350        360 
FEIEKRESMF VFSSDDEEVT PARAVSRHFE DTSYGYKDFS RHGMHVPTFR VQDYCWEDHG 
       370        380        390        400        410        420 
YSLVNRLYPD VGQLIDEKFH IAYNLTYNTM AMHKDVDTSM LRRAIWNYIH CMFGIRYDDY 
       430        440        450        460        470        480 
DYGEINQLLD RSFKVYIKTV VCTPEKVTKR MYDSFWRQFK HSEKVHVNLL LIEARMQAEL 
       490    
LYALRAITRY MT

Isoforms

- Isoform T1 of Sestrin-1 - Isoform T3 of Sestrin-1

Sequence View

        10         20         30         40         50         60 
MRLAAAANEA YTAPLAVSGL LGCKQCGGGR DQDEELGIRI PRPLGQGPSR FIPEKEILQV 
        70         80         90        100        110        120 
GSEDAQMHAL FADSFAALGR LDNITLVMVF HPQYLESFLK TQHYLLQMDG PLPLHYRHYI 
       130        140        150        160        170        180 
GIMAAARHQC SYLVNLHVND FLHVGGDPKW LNGLENAPQK LQNLGELNKV LAHRPWLITK 
       190        200        210        220        230        240 
EHIEGLLKAE EHSWSLAELV HAVVLLTHYH SLASFTFGCG ISPEIHCDGG HTFRPPSVSN 
       250        260        270        280        290        300 
YCICDITNGN HSVDEMPVNS AENVSVSDSF FEVEALMEKM RQLQECRDEE EASQEEMASR 
       310        320        330        340        350        360 
FEIEKRESMF VFSSDDEEVT PARAVSRHFE DTSYGYKDFS RHGMHVPTFR VQDYCWEDHG 
       370        380        390        400        410        420 
YSLVNRLYPD VGQLIDEKFH IAYNLTYNTM AMHKDVDTSM LRRAIWNYIH CMFGIRYDDY 
       430        440        450        460        470        480 
DYGEINQLLD RSFKVYIKTV VCTPEKVTKR MYDSFWRQFK HSEKVHVNLL LIEARMQAEL 
       490    
LYALRAITRY MT         10         20         30         40         50         60 
MRLAAAANEA YTAPLAVSGL LGCKQCGGGR DQDEELGIRI PRPLGQGPSR FIPEKEILQV 
        70         80         90        100        110        120 
GSEDAQMHAL FADSFAALGR LDNITLVMVF HPQYLESFLK TQHYLLQMDG PLPLHYRHYI 
       130        140        150        160        170        180 
GIMAAARHQC SYLVNLHVND FLHVGGDPKW LNGLENAPQK LQNLGELNKV LAHRPWLITK 
       190        200        210        220        230        240 
EHIEGLLKAE EHSWSLAELV HAVVLLTHYH SLASFTFGCG ISPEIHCDGG HTFRPPSVSN 
       250        260        270        280        290        300 
YCICDITNGN HSVDEMPVNS AENVSVSDSF FEVEALMEKM RQLQECRDEE EASQEEMASR 
       310        320        330        340        350        360 
FEIEKRESMF VFSSDDEEVT PARAVSRHFE DTSYGYKDFS RHGMHVPTFR VQDYCWEDHG 
       370        380        390        400        410        420 
YSLVNRLYPD VGQLIDEKFH IAYNLTYNTM AMHKDVDTSM LRRAIWNYIH CMFGIRYDDY 
       430        440        450        460        470        480 
DYGEINQLLD RSFKVYIKTV VCTPEKVTKR MYDSFWRQFK HSEKVHVNLL LIEARMQAEL 
       490    
LYALRAITRY MT



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Y6P5-1-unknown MRLAAA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9Y6P5-67-unknown MHALFA... 67 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89326
    Q9Y6P5-67-unknown MHALFA... 67 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt109078

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)