TopFIND 4.0

Q9Y6W8: Inducible T-cell costimulator

General Information

Protein names
- Inducible T-cell costimulator
- Activation-inducible lymphocyte immunomediatory molecule
- CD278
Gene names ICOS
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Y6W8

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ 
        70         80         90        100        110        120 
ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK 
       130        140        150        160        170        180 
VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY 
       190    
MFMRAVNTAK KSRLTDVTL

Isoforms

- Isoform 2 of Inducible T-cell costimulator

Sequence View

        10         20         30         40         50         60 
MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ 
        70         80         90        100        110        120 
ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK 
       130        140        150        160        170        180 
VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY 
       190    
MFMRAVNTAK KSRLTDVTL



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Y6W8-1-unknown MKSGLW... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77498
    Q9Y6W8-21-unknown EINGSA... 21 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9Y6W8-21-unknown EINGSA... 21 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt112725

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...TDVTL 199 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)