Q9Z0E3: Autoimmune regulator

General Information

Protein names	- Autoimmune regulator - Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog - APECED protein homolog
Gene names	Aire
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Z0E3

1 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1b of Autoimmune regulator - Isoform 1c of Autoimmune regulator - Isoform 1d of Autoimmune regulator - Isoform 2a of Autoimmune regulator - Isoform 2b of Autoimmune regulator - Isoform 2c of Autoimmune regulator - Isoform 2d of Autoimmune regulator - Isoform 3a of Autoimmune regulator - Isoform 3b of Autoimmune regulator - Isoform 3c of Autoimmune regulator - Isoform 3d of Autoimmune regulator

Sequence View

        10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS         10         20         30         40         50         60
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF
        70         80         90        100        110        120
HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG FPKDVDLNQS RKGRKPLAGP
       130        140        150        160        170        180
KAAVLPPRPP TKRKALEEPR ATPPATLASK SVSSPGSHLK TKPPKKPDGN LESQHLPLGN
       190        200        210        220        230        240
GIQTMAASVQ RAVTVASGDV PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP
       250        260        270        280        290        300
SGNLKNKARS GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
       310        320        330        340        350        360
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN LSQPEVSRPP
       370        380        390        400        410        420
ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL APHPAAPLLE PSALCPLLSA
       430        440        450        460        470        480
GNEGRPGPAP SARCSVCGDG TEVLRCAHCA AAFHWRCHFP TAAARPGTNL RCKSCSADST
       490        500        510        520        530        540
PTPGTPGEAV PTSGPRPAPG LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM
       550
SRPLAETPPF SS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66589
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66590
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66591
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66592
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66593
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66594
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66595
Q9Z0E3-1-unknown	MAGGDG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66596

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPFSS	552	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62213
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62212
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62211
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62210
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62209
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62208
...PPFSS	552	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62207

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)