TopFIND 4.0

Q9Z2R9: Eukaryotic translation initiation factor 2-alpha kinase 1

General Information

Protein names
- Eukaryotic translation initiation factor 2-alpha kinase 1
- 2.7.11.1
- Heme-controlled repressor
- HCR
- Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
- Heme-regulated inhibitor
- Hemin-sensitive initiation factor 2-alpha kinase
Gene names Eif2ak1
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9Z2R9

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLGGSSVDGE RDTDDDAAGA VAAPPAIDFP AEVSDPKYDE SDVPAELQVL KEPLQQPTFP 
        70         80         90        100        110        120 
FLVANQLLLV SLLEHLSHVH EPNPLHSKQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 
       130        140        150        160        170        180 
NRAITHLMRS AKERVRQDPC QDNSYMQKIR SREIAFEAQT SRYLNEFEEL AILGKGGYGR 
       190        200        210        220        230        240 
VYKVRNKLDG QHYAIKKILI KSATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVV 
       250        260        270        280        290        300 
QPQDRVPIQL PSLEVLSEQE GDRDQGGVKD NESSSSIVFA ELTPEKEKPF GESEVKNENN 
       310        320        330        340        350        360 
NLVSYTANLV VRNSSESESS IELQEDGLTD LSVRPVVRHQ LPLGHSSELE GNFTSTDESS 
       370        380        390        400        410        420 
EGNLNLLGQT EVRYHLMLHI QMQLCELSLW DWITERNKRS REYVDEAACP YVMASVATKI 
       430        440        450        460        470        480 
FQELVEGVFY IHNMGIVHRD LKPRNIFLHG PDQQVKIGDF GLACADIIQN ADWTNRNGKG 
       490        500        510        520        530        540 
TRTHTSRVGT CLYASPEQLE GSQYDAKSDM YSLGVILLEL FQPFGTEMER ATVLTGVRTG 
       550        560        570        580        590        600 
RIPESLSKRC PVQAKYIQLL TGRNVSQRPS ALQLLQSELF QTTGNVNLTL QMKIIEQEKE 
       610    
IEELKKQLSL LSQDRGLKR

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9Z2R9-1-unknown MLGGSS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RGLKR 619 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)