A0FGR8: Extended synaptotagmin-2 {ECO:0000305}

General Information

Protein names	- Extended synaptotagmin-2 {ECO:0000305} - E-Syt2 {ECO:0000303\|PubMed:29469807} - Chr2Syt
Gene names	ESYT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	A0FGR8

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Extended synaptotagmin-2 - Isoform 4 of Extended synaptotagmin-2 - Isoform 5 of Extended synaptotagmin-2 - Isoform 6 of Extended synaptotagmin-2

Sequence View

        10         20         30         40         50         60
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR
        70         80         90        100        110        120
RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF
       130        140        150        160        170        180
ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA
       190        200        210        220        230        240
CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV
       250        260        270        280        290        300
DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
       310        320        330        340        350        360
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV
       370        380        390        400        410        420
LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV
       430        440        450        460        470        480
GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE
       490        500        510        520        530        540
KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL
       550        560        570        580        590        600
YLDSARNLPS GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
       610        620        630        640        650        660
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI ALRVLHLEKR
       670        680        690        700        710        720
ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN TAPSTPVIGG SDKPGMEEKA
       730        740        750        760        770        780
QPPEAGPQGL HDLGRSSSSL LASPGHISVK EPTPSIASDI SLPIATQELR QRLRQLENGT
       790        800        810        820        830        840
TLGQSPLGQI QLTIRHSSQR NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK
       850        860        870        880        890        900
THVSKKTLNP VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
       910        920
AKGWTQWYDL TEDGTRPQAM T         10         20         30         40         50         60
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR
        70         80         90        100        110        120
RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF
       130        140        150        160        170        180
ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA
       190        200        210        220        230        240
CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV
       250        260        270        280        290        300
DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
       310        320        330        340        350        360
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV
       370        380        390        400        410        420
LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV
       430        440        450        460        470        480
GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE
       490        500        510        520        530        540
KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL
       550        560        570        580        590        600
YLDSARNLPS GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
       610        620        630        640        650        660
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI ALRVLHLEKR
       670        680        690        700        710        720
ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN TAPSTPVIGG SDKPGMEEKA
       730        740        750        760        770        780
QPPEAGPQGL HDLGRSSSSL LASPGHISVK EPTPSIASDI SLPIATQELR QRLRQLENGT
       790        800        810        820        830        840
TLGQSPLGQI QLTIRHSSQR NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK
       850        860        870        880        890        900
THVSKKTLNP VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
       910        920
AKGWTQWYDL TEDGTRPQAM T         10         20         30         40         50         60
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR
        70         80         90        100        110        120
RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF
       130        140        150        160        170        180
ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA
       190        200        210        220        230        240
CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV
       250        260        270        280        290        300
DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
       310        320        330        340        350        360
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV
       370        380        390        400        410        420
LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV
       430        440        450        460        470        480
GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE
       490        500        510        520        530        540
KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL
       550        560        570        580        590        600
YLDSARNLPS GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
       610        620        630        640        650        660
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI ALRVLHLEKR
       670        680        690        700        710        720
ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN TAPSTPVIGG SDKPGMEEKA
       730        740        750        760        770        780
QPPEAGPQGL HDLGRSSSSL LASPGHISVK EPTPSIASDI SLPIATQELR QRLRQLENGT
       790        800        810        820        830        840
TLGQSPLGQI QLTIRHSSQR NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK
       850        860        870        880        890        900
THVSKKTLNP VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
       910        920
AKGWTQWYDL TEDGTRPQAM T         10         20         30         40         50         60
MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR
        70         80         90        100        110        120
RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF
       130        140        150        160        170        180
ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA
       190        200        210        220        230        240
CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV
       250        260        270        280        290        300
DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM
       310        320        330        340        350        360
RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV
       370        380        390        400        410        420
LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV
       430        440        450        460        470        480
GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE
       490        500        510        520        530        540
KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL
       550        560        570        580        590        600
YLDSARNLPS GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL
       610        620        630        640        650        660
EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI ALRVLHLEKR
       670        680        690        700        710        720
ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN TAPSTPVIGG SDKPGMEEKA
       730        740        750        760        770        780
QPPEAGPQGL HDLGRSSSSL LASPGHISVK EPTPSIASDI SLPIATQELR QRLRQLENGT
       790        800        810        820        830        840
TLGQSPLGQI QLTIRHSSQR NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK
       850        860        870        880        890        900
THVSKKTLNP VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL
       910        920
AKGWTQWYDL TEDGTRPQAM T

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
A0FGR8-1-unknown	MTANRD...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
A0FGR8-1-unknown	MTANRD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74250
A0FGR8-205-unknown	MWPFIC...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74248
A0FGR8-205-unknown	MWPFIC...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96238
A0FGR8-205-unknown	MWPFIC...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96237
A0FGR8-760-unknown	ISLPIA...	760	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10617
A0FGR8-760-unknown	ISLPIA...	760	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145416
A0FGR8-760-unknown	ISLPIA...	760	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156144
A0FGR8-760-unknown	ISLPIA...	760	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156426

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SIASDI	759	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10617
...SIASDI	759	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128709
...SIASDI	759	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139610
...SIASDI	759	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139906
...PQAMT	921	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PQAMT	921	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69867
...PQAMT	921	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69865
...PQAMT	921	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69868

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	759	ASDI.\|.ISLP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)