A1Z1Q3: ADP-ribose glycohydrolase MACROD2 {ECO:0000305}

General Information

Protein names	- ADP-ribose glycohydrolase MACROD2 {ECO:0000305} - MACRO domain-containing protein 2 {ECO:0000303\|PubMed:23474712} - O-acetyl-ADP-ribose deacetylase MACROD2 - 3.5.1.- {ECO:0000305\|PubMed:21257746} - Protein ADP-ribosylaspartate] hydrolase MACROD2 {ECO:0000305} - 3.2.2.- {ECO:0000269\|PubMed:23474714} - Protein ADP-ribosylglutamate] hydrolase MACROD2 {ECO:0000305} - 3.2.2.- {ECO:0000269\|PubMed:23474712, ECO:0000269\|PubMed:23474714}
Gene names	MACROD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	A1Z1Q3

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of O-acetyl-ADP-ribose deacetylase MACROD2 - Isoform 4 of O-acetyl-ADP-ribose deacetylase MACROD2 - Isoform 5 of O-acetyl-ADP-ribose deacetylase MACROD2 - Isoform 6 of O-acetyl-ADP-ribose deacetylase MACROD2 - Isoform 1 of ADP-ribose glycohydrolase MACROD2 - Isoform 4 of ADP-ribose glycohydrolase MACROD2 - Isoform 5 of ADP-ribose glycohydrolase MACROD2 - Isoform 6 of ADP-ribose glycohydrolase MACROD2

Sequence View

        10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK         10         20         30         40         50         60
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
        70         80         90        100        110        120
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
       130        140        150        160        170        180
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
       190        200        210        220        230        240
AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
       250        260        270        280        290        300
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
       310        320        330        340        350        360
DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
       370        380        390        400        410        420
DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ

RNGTK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
A1Z1Q3-1-unknown	MYPSNK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
A1Z1Q3-1-unknown	MYPSNK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80249
A1Z1Q3-96-unknown	LGGGGV...	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3235
A1Z1Q3-96-unknown	LGGGGV...	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142208
A1Z1Q3-98-unknown	GGGVDG...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3237
A1Z1Q3-98-unknown	GGGVDG...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142297
A1Z1Q3-236-unknown	MNEFFS...	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80250
A1Z1Q3-236-unknown	MNEFFS...	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80251
A1Z1Q3-236-unknown	MNEFFS...	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102830
A1Z1Q3-350-unknown	METEEL...	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80252
A1Z1Q3-350-unknown	METEEL...	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102937
A1Z1Q3-350-unknown	METEEL...	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102938
A1Z1Q3-350-unknown	METEEL...	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102939

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ANASLL	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3235
...ANASLL	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125396
...ASLLGG	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3237
...ASLLGG	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125488
...	448	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...	448	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75868

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	95	ASLL.\|.LGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	97	LLGG.\|.GGGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)