A3KMH1: von Willebrand factor A domain-containing protein 8
| Protein names | - von Willebrand factor A domain-containing protein 8 - PEX7-binding protein 2 {ECO:0000303|PubMed:30204880} - P7BP2 {ECO:0000303|PubMed:30204880} |
|---|---|
| Gene names | VWA8 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | A3KMH1 |
4
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MQSRLLLLGA PGGHGGPASR RMRLLLRQVV QRRPGGDRQR PEVRLLHAGS GADTGDTVNI
70 80 90 100 110 120
GDVSYKLKIP KNPELVPQNY ISDSLAQSVV QHLRWIMQKD LLGQDVFLIG PPGPLRRSIA
130 140 150 160 170 180
MQYLELTKRE VEYIALSRDT TETDLKQRRE IRAGTAFYID QCAVRAATEG RTLILEGLEK
190 200 210 220 230 240
AERNVLPVLN NLLENREMQL EDGRFLMSAE RYDKLLRDHT KKELDSWKIV RVSENFRVIA
250 260 270 280 290 300
LGLPVPRYSG NPLDPPLRSR FQARDIYYLP FKDQLKLLYS IGANVSAEKV SQLLSFATTL
310 320 330 340 350 360
CSQESSTLGL PDFPLDSLAA AVQILDSFPM MPIKHAIQWL YPYSILLGHE GKMAVEGVLK
370 380 390 400 410 420
RFELQDSGSS LLPKEIVKVE KMMENHVSQA SVTIRIADKE VTIKVPAGTR LLSQPCASDR
430 440 450 460 470 480
FIQTLSHKQL QAEMMQSHMV KDICLIGGKG CGKTVIAKNF ADTLGYNIEP IMLYQDMTAR
490 500 510 520 530 540
DLLQQRYTLP NGDTAWRSSP LVNAALEGKL VLLDGIHRVN AGTLAVLQRL IHDRELSLYD
550 560 570 580 590 600
GSRLLREDRY MRLKEELQLS DEQLQKRSIF PIHPSFRIIA LAEPPVIGST AHQWLGPEFL
610 620 630 640 650 660
TMFFFHYMKP LVKSEEIQVI KEKVPNVPQE ALDKLLSFTH KLRETQDPTA QSLAASLSTR
670 680 690 700 710 720
QLLRISRRLS QYPNENLHSA VTKACLSRFL PSLARSALEK NLADATIEIN TDDNLEPELK
730 740 750 760 770 780
DYKCEVTSGT LRIGAVSAPI YNAHEKMKVP DVLFYDNIQH VIVMEDMLKD FLLGEHLLLV
790 800 810 820 830 840
GNQGVGKNKI VDRFLHLLNR PREYIQLHRD TTVQTLTLQP SVKDGLIVYE DSPLVKAVKL
850 860 870 880 890 900
GHILVVDEAD KAPTNVTCIL KTLVENGEMI LADGRRIVAN SANVNGRENV VVIHPDFRMI
910 920 930 940 950 960
VLANRPGFPF LGNDFFGTLG DIFSCHAVDN PKPHSELEML RQYGPNVPEP ILQKLVAAFG
970 980 990 1000 1010 1020
ELRSLADQGI INYPYSTREV VNIVKHLQKF PTEGLSSVVR NVFDFDSYNN DMREILINTL
1030 1040 1050 1060 1070 1080
HKYGIPIGAK PTSVQLAKEL TLPEQTFMGY WTIGQARSGM QKLLCPVETH HIDIKGPALI
1090 1100 1110 1120 1130 1140
NIQEYPIERH EERSLNFTEE CASWRIPLDE INIICDIATS HENEQNTLYV VTCNPASLYF
1150 1160 1170 1180 1190 1200
MNMTGKSGFF VDFFDIFPRT ANGVWHPFVT VAPLGSPLKG QVVLHEQQSN VILLLDTTGR
1210 1220 1230 1240 1250 1260
ALHRLILPSE KFTSKKPFWW NKEEAETYKM CKEFSHKNWL VFYKEKGNSL TVLDVLEGRT
1270 1280 1290 1300 1310 1320
HTISLPINLK TVFLVAEDKW LLVESKTNQK YLLTKPAHIE SEGSGVCQLY VLKEEPPSTG
1330 1340 1350 1360 1370 1380
FGVTQETEFS IPHKISSDQL SSEHLSSAVE QKIASPNRIL SDEKNYATIV VGFPDLMSPS
1390 1400 1410 1420 1430 1440
EVYSWKRPSS LHKRSGTDTS FYRGKKKRGT PKQSNCVTLL DTNQVVRILP PGEVPLKDIY
1450 1460 1470 1480 1490 1500
PKDVTPPQTS GYIEVTDLQS KKLRYIPIPR SESLSPYTTW LSTISDTDAL LAEWDKSGVV
1510 1520 1530 1540 1550 1560
TVDMGGHIRL WETGLERLQR SLMEWRNMIG QDDRNMQITI NRDSGEDVSS PKHGKEDPDN
1570 1580 1590 1600 1610 1620
MPHVGGNTWA GGTGGRDTAG LGGKGGPYRL DAGHTVYQVS QAEKDAVPEE VKRAAREMGQ
1630 1640 1650 1660 1670 1680
RAFQQRLKEI QMSEYDAATY ERFSGAVRRQ VHSLRIILDN LQAKGKERQW LRHQATGELD
1690 1700 1710 1720 1730 1740
DAKIIDGLTG EKAIYKRRGE LEPQLGSPQQ KPKRLRLVVD VSGSMYRFNR MDGRLERTME
1750 1760 1770 1780 1790 1800
AVCMVMEAFE NYEEKFQYDI VGHSGDGYNI GLVPMNKIPK DNKQRLEILK TMHAHSQFCM
1810 1820 1830 1840 1850 1860
SGDHTLEGTE HAIKEIVKEE ADEYFVIVLS DANLSRYGIH PAKFAQILTR DPQVNAFAIF
1870 1880 1890 1900
IGSLGDQATR LQRTLPAGRS FVAMDTKDIP QILQQIFTST MLSSV
Isoforms
- Isoform 2 of von Willebrand factor A domain-containing protein 8 - Isoform 3 of von Willebrand factor A domain-containing protein 8Sequence View
10 20 30 40 50 60
MQSRLLLLGA PGGHGGPASR RMRLLLRQVV QRRPGGDRQR PEVRLLHAGS GADTGDTVNI
70 80 90 100 110 120
GDVSYKLKIP KNPELVPQNY ISDSLAQSVV QHLRWIMQKD LLGQDVFLIG PPGPLRRSIA
130 140 150 160 170 180
MQYLELTKRE VEYIALSRDT TETDLKQRRE IRAGTAFYID QCAVRAATEG RTLILEGLEK
190 200 210 220 230 240
AERNVLPVLN NLLENREMQL EDGRFLMSAE RYDKLLRDHT KKELDSWKIV RVSENFRVIA
250 260 270 280 290 300
LGLPVPRYSG NPLDPPLRSR FQARDIYYLP FKDQLKLLYS IGANVSAEKV SQLLSFATTL
310 320 330 340 350 360
CSQESSTLGL PDFPLDSLAA AVQILDSFPM MPIKHAIQWL YPYSILLGHE GKMAVEGVLK
370 380 390 400 410 420
RFELQDSGSS LLPKEIVKVE KMMENHVSQA SVTIRIADKE VTIKVPAGTR LLSQPCASDR
430 440 450 460 470 480
FIQTLSHKQL QAEMMQSHMV KDICLIGGKG CGKTVIAKNF ADTLGYNIEP IMLYQDMTAR
490 500 510 520 530 540
DLLQQRYTLP NGDTAWRSSP LVNAALEGKL VLLDGIHRVN AGTLAVLQRL IHDRELSLYD
550 560 570 580 590 600
GSRLLREDRY MRLKEELQLS DEQLQKRSIF PIHPSFRIIA LAEPPVIGST AHQWLGPEFL
610 620 630 640 650 660
TMFFFHYMKP LVKSEEIQVI KEKVPNVPQE ALDKLLSFTH KLRETQDPTA QSLAASLSTR
670 680 690 700 710 720
QLLRISRRLS QYPNENLHSA VTKACLSRFL PSLARSALEK NLADATIEIN TDDNLEPELK
730 740 750 760 770 780
DYKCEVTSGT LRIGAVSAPI YNAHEKMKVP DVLFYDNIQH VIVMEDMLKD FLLGEHLLLV
790 800 810 820 830 840
GNQGVGKNKI VDRFLHLLNR PREYIQLHRD TTVQTLTLQP SVKDGLIVYE DSPLVKAVKL
850 860 870 880 890 900
GHILVVDEAD KAPTNVTCIL KTLVENGEMI LADGRRIVAN SANVNGRENV VVIHPDFRMI
910 920 930 940 950 960
VLANRPGFPF LGNDFFGTLG DIFSCHAVDN PKPHSELEML RQYGPNVPEP ILQKLVAAFG
970 980 990 1000 1010 1020
ELRSLADQGI INYPYSTREV VNIVKHLQKF PTEGLSSVVR NVFDFDSYNN DMREILINTL
1030 1040 1050 1060 1070 1080
HKYGIPIGAK PTSVQLAKEL TLPEQTFMGY WTIGQARSGM QKLLCPVETH HIDIKGPALI
1090 1100 1110 1120 1130 1140
NIQEYPIERH EERSLNFTEE CASWRIPLDE INIICDIATS HENEQNTLYV VTCNPASLYF
1150 1160 1170 1180 1190 1200
MNMTGKSGFF VDFFDIFPRT ANGVWHPFVT VAPLGSPLKG QVVLHEQQSN VILLLDTTGR
1210 1220 1230 1240 1250 1260
ALHRLILPSE KFTSKKPFWW NKEEAETYKM CKEFSHKNWL VFYKEKGNSL TVLDVLEGRT
1270 1280 1290 1300 1310 1320
HTISLPINLK TVFLVAEDKW LLVESKTNQK YLLTKPAHIE SEGSGVCQLY VLKEEPPSTG
1330 1340 1350 1360 1370 1380
FGVTQETEFS IPHKISSDQL SSEHLSSAVE QKIASPNRIL SDEKNYATIV VGFPDLMSPS
1390 1400 1410 1420 1430 1440
EVYSWKRPSS LHKRSGTDTS FYRGKKKRGT PKQSNCVTLL DTNQVVRILP PGEVPLKDIY
1450 1460 1470 1480 1490 1500
PKDVTPPQTS GYIEVTDLQS KKLRYIPIPR SESLSPYTTW LSTISDTDAL LAEWDKSGVV
1510 1520 1530 1540 1550 1560
TVDMGGHIRL WETGLERLQR SLMEWRNMIG QDDRNMQITI NRDSGEDVSS PKHGKEDPDN
1570 1580 1590 1600 1610 1620
MPHVGGNTWA GGTGGRDTAG LGGKGGPYRL DAGHTVYQVS QAEKDAVPEE VKRAAREMGQ
1630 1640 1650 1660 1670 1680
RAFQQRLKEI QMSEYDAATY ERFSGAVRRQ VHSLRIILDN LQAKGKERQW LRHQATGELD
1690 1700 1710 1720 1730 1740
DAKIIDGLTG EKAIYKRRGE LEPQLGSPQQ KPKRLRLVVD VSGSMYRFNR MDGRLERTME
1750 1760 1770 1780 1790 1800
AVCMVMEAFE NYEEKFQYDI VGHSGDGYNI GLVPMNKIPK DNKQRLEILK TMHAHSQFCM
1810 1820 1830 1840 1850 1860
SGDHTLEGTE HAIKEIVKEE ADEYFVIVLS DANLSRYGIH PAKFAQILTR DPQVNAFAIF
1870 1880 1890 1900
IGSLGDQATR LQRTLPAGRS FVAMDTKDIP QILQQIFTST MLSSV
10 20 30 40 50 60
MQSRLLLLGA PGGHGGPASR RMRLLLRQVV QRRPGGDRQR PEVRLLHAGS GADTGDTVNI
70 80 90 100 110 120
GDVSYKLKIP KNPELVPQNY ISDSLAQSVV QHLRWIMQKD LLGQDVFLIG PPGPLRRSIA
130 140 150 160 170 180
MQYLELTKRE VEYIALSRDT TETDLKQRRE IRAGTAFYID QCAVRAATEG RTLILEGLEK
190 200 210 220 230 240
AERNVLPVLN NLLENREMQL EDGRFLMSAE RYDKLLRDHT KKELDSWKIV RVSENFRVIA
250 260 270 280 290 300
LGLPVPRYSG NPLDPPLRSR FQARDIYYLP FKDQLKLLYS IGANVSAEKV SQLLSFATTL
310 320 330 340 350 360
CSQESSTLGL PDFPLDSLAA AVQILDSFPM MPIKHAIQWL YPYSILLGHE GKMAVEGVLK
370 380 390 400 410 420
RFELQDSGSS LLPKEIVKVE KMMENHVSQA SVTIRIADKE VTIKVPAGTR LLSQPCASDR
430 440 450 460 470 480
FIQTLSHKQL QAEMMQSHMV KDICLIGGKG CGKTVIAKNF ADTLGYNIEP IMLYQDMTAR
490 500 510 520 530 540
DLLQQRYTLP NGDTAWRSSP LVNAALEGKL VLLDGIHRVN AGTLAVLQRL IHDRELSLYD
550 560 570 580 590 600
GSRLLREDRY MRLKEELQLS DEQLQKRSIF PIHPSFRIIA LAEPPVIGST AHQWLGPEFL
610 620 630 640 650 660
TMFFFHYMKP LVKSEEIQVI KEKVPNVPQE ALDKLLSFTH KLRETQDPTA QSLAASLSTR
670 680 690 700 710 720
QLLRISRRLS QYPNENLHSA VTKACLSRFL PSLARSALEK NLADATIEIN TDDNLEPELK
730 740 750 760 770 780
DYKCEVTSGT LRIGAVSAPI YNAHEKMKVP DVLFYDNIQH VIVMEDMLKD FLLGEHLLLV
790 800 810 820 830 840
GNQGVGKNKI VDRFLHLLNR PREYIQLHRD TTVQTLTLQP SVKDGLIVYE DSPLVKAVKL
850 860 870 880 890 900
GHILVVDEAD KAPTNVTCIL KTLVENGEMI LADGRRIVAN SANVNGRENV VVIHPDFRMI
910 920 930 940 950 960
VLANRPGFPF LGNDFFGTLG DIFSCHAVDN PKPHSELEML RQYGPNVPEP ILQKLVAAFG
970 980 990 1000 1010 1020
ELRSLADQGI INYPYSTREV VNIVKHLQKF PTEGLSSVVR NVFDFDSYNN DMREILINTL
1030 1040 1050 1060 1070 1080
HKYGIPIGAK PTSVQLAKEL TLPEQTFMGY WTIGQARSGM QKLLCPVETH HIDIKGPALI
1090 1100 1110 1120 1130 1140
NIQEYPIERH EERSLNFTEE CASWRIPLDE INIICDIATS HENEQNTLYV VTCNPASLYF
1150 1160 1170 1180 1190 1200
MNMTGKSGFF VDFFDIFPRT ANGVWHPFVT VAPLGSPLKG QVVLHEQQSN VILLLDTTGR
1210 1220 1230 1240 1250 1260
ALHRLILPSE KFTSKKPFWW NKEEAETYKM CKEFSHKNWL VFYKEKGNSL TVLDVLEGRT
1270 1280 1290 1300 1310 1320
HTISLPINLK TVFLVAEDKW LLVESKTNQK YLLTKPAHIE SEGSGVCQLY VLKEEPPSTG
1330 1340 1350 1360 1370 1380
FGVTQETEFS IPHKISSDQL SSEHLSSAVE QKIASPNRIL SDEKNYATIV VGFPDLMSPS
1390 1400 1410 1420 1430 1440
EVYSWKRPSS LHKRSGTDTS FYRGKKKRGT PKQSNCVTLL DTNQVVRILP PGEVPLKDIY
1450 1460 1470 1480 1490 1500
PKDVTPPQTS GYIEVTDLQS KKLRYIPIPR SESLSPYTTW LSTISDTDAL LAEWDKSGVV
1510 1520 1530 1540 1550 1560
TVDMGGHIRL WETGLERLQR SLMEWRNMIG QDDRNMQITI NRDSGEDVSS PKHGKEDPDN
1570 1580 1590 1600 1610 1620
MPHVGGNTWA GGTGGRDTAG LGGKGGPYRL DAGHTVYQVS QAEKDAVPEE VKRAAREMGQ
1630 1640 1650 1660 1670 1680
RAFQQRLKEI QMSEYDAATY ERFSGAVRRQ VHSLRIILDN LQAKGKERQW LRHQATGELD
1690 1700 1710 1720 1730 1740
DAKIIDGLTG EKAIYKRRGE LEPQLGSPQQ KPKRLRLVVD VSGSMYRFNR MDGRLERTME
1750 1760 1770 1780 1790 1800
AVCMVMEAFE NYEEKFQYDI VGHSGDGYNI GLVPMNKIPK DNKQRLEILK TMHAHSQFCM
1810 1820 1830 1840 1850 1860
SGDHTLEGTE HAIKEIVKEE ADEYFVIVLS DANLSRYGIH PAKFAQILTR DPQVNAFAIF
1870 1880 1890 1900
IGSLGDQATR LQRTLPAGRS FVAMDTKDIP QILQQIFTST MLSSV
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| A3KMH1-1-unknown | MQSRLL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt94362 | |||
| A3KMH1-16-unknown | GPASRR... | 16 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| A3KMH1-16-unknown | GPASRR... | 16 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111792 | |||
| A3KMH1-46-unknown | LHAGSG... | 46 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164542 | |||
| A3KMH1-46- | LHAGSG... | 46 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
| A3KMH1-46- | LHAGSG... | 46 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
| A3KMH1-46- | LHAGSG... | 46 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
| A3KMH1-46- | LHAGSG... | 46 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
| A3KMH1-46- | LHAGSG... | 46 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
| A3KMH1-46- | LHAGSG... | 46 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...QLAKEL | 1039 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89980 | |||
| ...QLAKEL | 1039 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93624 | |||
| ...MLSSV | 1905 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...MLSSV | 1905 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89981 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|