A6NHC0: Calpain-8

General Information

Protein names	- Calpain-8 - 3.4.22.53 - New calpain 2 - nCL-2 - Stomach-specific M-type calpain
Gene names	CAPN8
Organism	Homo sapiens
Protease Family	C02.007
Protease ID	C02.007
Chromosome location
UniProt ID	A6NHC0

2 N-termini

2 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MAAQAAGVSR QRAATQGLGS NQNALKYLGQ DFKTLRQQCL DSGVLFKDPE FPACPSALGY
        70         80         90        100        110        120
KDLGPGSPQT QGIIWKRPTE LCPSPQFIVG GATRTDICQG GLGDCWLLAA IASLTLNEEL
       130        140        150        160        170        180
LYRVVPRDQD FQENYAGIFH FQFWQYGEWV EVVIDDRLPT KNGQLLFLHS EQGNEFWSAL
       190        200        210        220        230        240
LEKAYAKLNG CYEALAGGST VEGFEDFTGG ISEFYDLKKP PANLYQIIRK ALCAGSLLGC
       250        260        270        280        290        300
SIDVSSAAEA EAITSQKLVK SHAYSVTGVE EVNFQGHPEK LIRLRNPWGE VEWSGAWSDD
       310        320        330        340        350        360
APEWNHIDPR RKEELDKKVE DGEFWMSLSD FVRQFSRLEI CNLSPDSLSS EEVHKWNLVL
       370        380        390        400        410        420
FNGHWTRGST AGGCQNYPAT YWTNPQFKIR LDEVDEDQEE SIGEPCCTVL LGLMQKNRRW
       430        440        450        460        470        480
RKRIGQGMLS IGYAVYQVPK ELESHTDAHL GRDFFLAYQP SARTSTYVNL REVSGRARLP
       490        500        510        520        530        540
PGEYLVVPST FEPFKDGEFC LRVFSEKKAQ ALEIGDVVAG NPYEPHPSEV DQEDDQFRRL
       550        560        570        580        590        600
FEKLAGKDSE ITANALKILL NEAFSKRTDI KFDGFNINTC REMISLLDSN GTGTLGAVEF
       610        620        630        640        650        660
KTLWLKIQKY LEIYWETDYN HSGTIDAHEM RTALRKAGFT LNSQVQQTIA LRYACSKLGI
       670        680        690        700
NFDSFVACMI RLETLFKLFS LLDEDKDGMV QLSLAEWLCC VLV

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
A6NHC0-1-unknown	MAAQAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
A6NHC0-548-unknown	DSEITA...	548	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409233
A6NHC0-548-unknown	DSEITA...	548	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390294

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...YAVYQV	437	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401665
	...CCVLV	703	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
COPB_HUMAN	528	ALSS.\|.SSRP	inferred from experiment	unknown	MEROPS	Sorimachi H	Hata S et al.:Stomach-specific calpain, nCL-2... (C02.007)	16476741,