P53618: Coatomer subunit beta

General Information

Protein names	- Coatomer subunit beta - Beta-coat protein - Beta-COP {ECO:0000303\|PubMed:7982906, ECO:0000303\|Ref.1}
Gene names	COPB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P53618

6 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTAAENVCYT LINVPMDSEP PSEISLKNDL EKGDVKSKTE ALKKVIIMIL NGEKLPGLLM
        70         80         90        100        110        120
TIIRFVLPLQ DHTIKKLLLV FWEIVPKTTP DGRLLHEMIL VCDAYRKDLQ HPNEFIRGST
       130        140        150        160        170        180
LRFLCKLKEA ELLEPLMPAI RACLEHRHSY VRRNAVLAIY TIYRNFEHLI PDAPELIHDF
       190        200        210        220        230        240
LVNEKDASCK RNAFMMLIHA DQDRALDYLS TCIDQVQTFG DILQLVIVEL IYKVCHANPS
       250        260        270        280        290        300
ERARFIRCIY NLLQSSSPAV KYEAAGTLVT LSSAPTAIKA AAQCYIDLII KESDNNVKLI
       310        320        330        340        350        360
VLDRLIELKE HPAHERVLQD LVMDILRVLS TPDLEVRKKT LQLALDLVSS RNVEELVIVL
       370        380        390        400        410        420
KKEVIKTNNV SEHEDTDKYR QLLVRTLHSC SVRFPDMAAN VIPVLMEFLS DNNEAAAADV
       430        440        450        460        470        480
LEFVREAIQR FDNLRMLIVE KMLEVFHAIK SVKIYRGALW ILGEYCSTKE DIQSVMTEIR
       490        500        510        520        530        540
RSLGEIPIVE SEIKKEAGEL KPEEEITVGP VQKLVTEMGT YATQSALSSS RPTKKEEDRP
       550        560        570        580        590        600
PLRGFLLDGD FFVAASLATT LTKIALRYVA LVQEKKKQNS FVAEAMLLMA TILHLGKSSL
       610        620        630        640        650        660
PKKPITDDDV DRISLCLKVL SECSPLMNDI FNKECRQSLS HMLSAKLEEE KLSQKKESEK
       670        680        690        700        710        720
RNVTVQPDDP ISFMQLTAKN EMNCKEDQFQ LSLLAAMGNT QRKEAADPLA SKLNKVTQLT
       730        740        750        760        770        780
GFSDPVYAEA YVHVNQYDIV LDVLVVNQTS DTLQNCTLEL ATLGDLKLVE KPSPLTLAPH
       790        800        810        820        830        840
DFANIKANVK VASTENGIIF GNIVYDVSGA ASDRNCVVLS DIHIDIMDYI QPATCTDAEF
       850        860        870        880        890        900
RQMWAEFEWE NKVTVNTNMV DLNDYLQHIL KSTNMKCLTP EKALSGYCGF MAANLYARSI
       910        920        930        940        950
FGEDALANVS IEKPIHQGPD AAVTGHIRIR AKSQGMALSL GDKINLSQKK TSI

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53618-2-unknown	MTAAEN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53618-2-Acetylation	TAAENV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53618-2-Acetylation	TAAENV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P53618-485-unknown	EIPIVE...	485		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17723
P53618-522-	ATQSAL...	522			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P53618-529-unknown	SSRPTK...	529		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1080
P53618-662-	NVTVQP...	662			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KEAELL	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000436401
...LEPLMP	137	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431530
...RRSLGE	484	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17723
...RSLGEI	485	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000436383
...QSALSS	528	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1080
...KKTSI	953		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKTSI	953		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KKTSI	953	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKTSI	953		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKTSI	953		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	484	SLGE.\|.EIPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CAN8_HUMAN	528	ALSS.\|.SSRP	inferred from experiment	unknown	MEROPS	Sorimachi H	Hata S et al.:Stomach-specific calpain, nCL-2... (C02.007)	16476741,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)