O00165: HCLS1-associated protein X-1

General Information

Protein names	- HCLS1-associated protein X-1 - HS1-associating protein X-1 - HAX-1 - HS1-binding protein 1 - HSP1BP-1
Gene names	HAX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00165

6 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of HCLS1-associated protein X-1 - Isoform 3 of HCLS1-associated protein X-1 - Isoform 4 of HCLS1-associated protein X-1 - Isoform 5 of HCLS1-associated protein X-1 - Isoform 6 of HCLS1-associated protein X-1

Sequence View

        10         20         30         40         50         60
MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE
        70         80         90        100        110        120
FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR
       130        140        150        160        170        180
EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR
       190        200        210        220        230        240
TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV
       250        260        270
TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR         10         20         30         40         50         60
MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE
        70         80         90        100        110        120
FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR
       130        140        150        160        170        180
EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR
       190        200        210        220        230        240
TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV
       250        260        270
TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR         10         20         30         40         50         60
MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE
        70         80         90        100        110        120
FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR
       130        140        150        160        170        180
EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR
       190        200        210        220        230        240
TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV
       250        260        270
TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR         10         20         30         40         50         60
MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE
        70         80         90        100        110        120
FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR
       130        140        150        160        170        180
EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR
       190        200        210        220        230        240
TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV
       250        260        270
TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR         10         20         30         40         50         60
MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE
        70         80         90        100        110        120
FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR
       130        140        150        160        170        180
EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR
       190        200        210        220        230        240
TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV
       250        260        270
TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00165-2-unknown	MSLFDL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00165-2-unknown	MSLFDL...	1		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16783
O00165-1-unknown	MSLFDL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76764
O00165-1-unknown	MSLFDL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76766
O00165-1-unknown	MSLFDL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76768
O00165-2-Acetylation	SLFDLF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00165-2-Acetylation	SLFDLF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110549
O00165-2-Acetylation	SLFDLF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110550
O00165-2-Acetylation	SLFDLF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110551
O00165-27-unknown	MTRDED...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76765
O00165-27-unknown	MTRDED...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108192
O00165-27-unknown	MTRDED...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108193
O00165-27-unknown	MTRDED...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108194
O00165-128-unknown	SMLKYP...	128		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1379
O00165-128-unknown	SMLKYP...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141296
O00165-128-unknown	SMLKYP...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142500
O00165-128-unknown	SMLKYP...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144125
O00165-128-	SMLKYP...	128			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00165-128-	SMLKYP...	128			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QTLRDS	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1379
...QTLRDS	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124459
...QTLRDS	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125695
...QTLRDS	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127376
...WFRSR	279	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WFRSR	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72385
...WFRSR	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72383
...WFRSR	279	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72382

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MAP12_HUMAN	1	.\|.SLFD	inferred from experiment	unknown	MEROPS		Merops MAP12_HUMAN -> HAX1_HUMAN @1
CASP3_HUMAN	127	LRDS.\|.SMLK	inferred from experiment	unknown	MEROPS	Park SG	Lee AY et al.:HS 1-associated protein X-1 is ... (C14.003)	18319618,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)