O00178: GTP-binding protein 1

General Information

Protein names	- GTP-binding protein 1 - G-protein 1 - GP-1 - GP1
Gene names	GTPBP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00178

8 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATERSRSAM DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG EALNGEPELD
        70         80         90        100        110        120
LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG SDGTEYGLSE ADMEASYATV
       130        140        150        160        170        180
KSMAEQIEAD VILLRERQEA GGRVRDYLVR KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL
       190        200        210        220        230        240
THGELDNGRG FARQKLFRHK HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI
       250        260        270        280        290        300
CEKSTKVITF IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
       310        320        330        340        350        360
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT ASNFSSERMC
       370        380        390        400        410        420
PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID DTYSVPGVGT VVSGTTLRGL
       430        440        450        460        470        480
IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM PVKEVRGGQT ASFALKKIKR SSIRKGMVMV
       490        500        510        520        530        540
SPRLNPQASW EFEAEILVLH HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV
       550        560        570        580        590        600
HFRFIKTPEY LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLT
       610        620        630        640        650        660
KRDEGGPSGG PAVGAPPPGD EASSVGAGQP AASSNLQPQP KPSSGGRRRG GQRHKVKSQG

ACVTPASGC

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00178-1-unknown	MATERS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00178-16-	ASMFAP...	16		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00178-16-	ASMFAP...	16		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00178-17-	SMFAPE...	17		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00178-17-	SMFAPE...	17		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00178-18-	MFAPEP...	18		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00178-19-	FAPEPS...	19		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00178-82-unknown	MWERMD...	82	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442881
O00178-82-unknown	MWERMD...	82	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439505
O00178-82-unknown	MWERMD...	82	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442628
O00178-220-unknown	SEGNVV...	220	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10631
O00178-423-unknown	LNDTLL...	423	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388147

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SYATVK	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442628
...VAVVGN	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439505
...ILGFDS	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10631
...DSHGGS	233	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442881
...PASGC	669	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	219	GFDS.\|.SEGN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)