O00267: Transcription elongation factor SPT5

General Information

Protein names	- Transcription elongation factor SPT5 - hSPT5 - DRB sensitivity-inducing factor 160 kDa subunit - DSIF p160 - DRB sensitivity-inducing factor large subunit - DSIF large subunit - Tat-cotransactivator 1 protein - Tat-CT1 protein
Gene names	SUPT5H
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00267

8 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDSEDSNFS EEEDSERSSD GEEAEVDEER RSAAGSEKEE EPEDEEEEEE EEEYDEEEEE
        70         80         90        100        110        120
EDDDRPPKKP RHGGFILDEA DVDDEYEDED QWEDGAEDIL EKEEIEASNI DNVVLDEDRS
       130        140        150        160        170        180
GARRLQNLWR DQREEELGEY YMKKYAKSSV GETVYGGSDE LSDDITQQQL LPGVKDPNLW
       190        200        210        220        230        240
TVKCKIGEER ATAISLMRKF IAYQFTDTPL QIKSVVAPEH VKGYIYVEAY KQTHVKQAIE
       250        260        270        280        290        300
GVGNLRLGYW NQQMVPIKEM TDVLKVVKEV ANLKPKSWVR LKRGIYKDDI AQVDYVEPSQ
       310        320        330        340        350        360
NTISLKMIPR IDYDRIKARM SLKDWFAKRK KFKRPPQRLF DAEKIRSLGG DVASDGDFLI
       370        380        390        400        410        420
FEGNRYSRKG FLFKSFAMSA VITEGVKPTL SELEKFEDQP EGIDLEVVTE STGKEREHNF
       430        440        450        460        470        480
QPGDNVEVCE GELINLQGKI LSVDGNKITI MPKHEDLKDM LEFPAQELRK YFKMGDHVKV
       490        500        510        520        530        540
IAGRFEGDTG LIVRVEENFV ILFSDLTMHE LKVLPRDLQL CSETASGVDV GGQHEWGELV
       550        560        570        580        590        600
QLDPQTVGVI VRLERETFQV LNMYGKVVTV RHQAVTRKKD NRFAVALDSE QNNIHVKDIV
       610        620        630        640        650        660
KVIDGPHSGR EGEIRHLFRS FAFLHCKKLV ENGGMFVCKT RHLVLAGGSK PRDVTNFTVG
       670        680        690        700        710        720
GFAPMSPRIS SPMHPSAGGQ RGGFGSPGGG SGGMSRGRGR RDNELIGQTV RISQGPYKGY
       730        740        750        760        770        780
IGVVKDATES TARVELHSTC QTISVDRQRL TTVGSRRPGG MTSTYGRTPM YGSQTPMYGS
       790        800        810        820        830        840
GSRTPMYGSQ TPLQDGSRTP HYGSQTPLHD GSRTPAQSGA WDPNNPNTPS RAEEEYEYAF
       850        860        870        880        890        900
DDEPTPSPQA YGGTPNPQTP GYPDPSSPQV NPQYNPQTPG TPAMYNTDQF SPYAAPSPQG
       910        920        930        940        950        960
SYQPSPSPQS YHQVAPSPAG YQNTHSPASY HPTPSPMAYQ ASPSPSPVGY SPMTPGAPSP
       970        980        990       1000       1010       1020
GGYNPHTPGS GIEQNSSDWV TTDIQVKVRD TYLDTQVVGQ TGVIRSVTGG MCSVYLKDSE
      1030       1040       1050       1060       1070       1080
KVVSISSEHL EPITPTKNNK VKVILGEDRE ATGVLLSIDG EDGIVRMDLD EQLKILNLRF

LGKLLEA

Isoforms

- Isoform 2 of Transcription elongation factor SPT5

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00267-1-unknown	MSDSED...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00267-1-unknown	MSDSED...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90555
O00267-587-unknown	LDSEQN...	587	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5092
O00267-587-unknown	LDSEQN...	587	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154375
O00267-658-unknown	TVGGFA...	658		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00267-658-unknown	TVGGFA...	658	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160306
O00267-658-	TVGGFA...	658		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O00267-804-unknown	SQTPLH...	804	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5094
O00267-804-unknown	SQTPLH...	804	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156484
O00267-820-unknown	AWDPNN...	820	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175807
O00267-820-	AWDPNN...	820		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00267-1027-unknown	SEHLEP...	1027	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5096
O00267-1027-unknown	SEHLEP...	1027	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157212

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RFAVAL	586	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5092
...RFAVAL	586	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137796
...TPHYGS	803	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5094
...TPHYGS	803	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139966
...VVSISS	1026	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5096
...VVSISS	1026	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140711
...KLLEA	1087		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KLLEA	1087	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KLLEA	1087	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt86173
...KLLEA	1087		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KLLEA	1087		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	586	AVAL.\|.LDSE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	803	HYGS.\|.SQTP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	1026	SISS.\|.SEHL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)