P07711: Cathepsin L1
Protein names | - Cathepsin L1 - 3.4.22.15 - Cathepsin L - Major excreted protein - MEP - Cathepsin L1 heavy chain - Cathepsin L1 light chain |
---|---|
Gene names | CTSL |
Organism | Homo sapiens |
Protease Family | C01.032 |
Protease ID | C01.032 |
Chromosome location | |
UniProt ID | P07711 |
7
N-termini
7
C-termini
5
Cleavages
1889
Substrates
Sequence
10 20 30 40 50 60
MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNMKMIE
70 80 90 100 110 120
LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW
130 140 150 160 170 180
REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG
190 200 210 220 230 240
GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA
250 260 270 280 290 300
TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN
310 320 330
SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
7 N-termini - 7 C-termini - 5 Cleavages - 1889 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P07711-18-unknown | TLTFDH... | 18 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P07711-21-unknown | FDHSLE... | 21 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5442 | |||
P07711-107-unknown | QEPLFY... | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5443 | |||
P07711-108-unknown | EPLFYE... | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5444 | |||
P07711-113-unknown | EAPRSV... | 113 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5445 | |||
P07711-114-unknown | APRSVD... | 114 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P07711-114-unknown | APRSVD... | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5446 | |||
P07711-292-unknown | NNKYWL... | 292 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SATLTF | 20 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5442 | |||
...KGKVFQ | 106 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5443 | |||
...GKVFQE | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5444 | |||
...EPLFYE | 112 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5445 | |||
...PLFYEA | 113 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5446 | |||
...GFESTE | 288 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SYPTV | 333 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 20 | TLTF.|.FDHS | inferred from experiment | unknown | MEROPS | Mort JS | Menard R et al.:Autocatalytic processing of rec... (C01.032) | 9468501, |
CATL1_HUMAN | 106 | KVFQ.|.QEPL | inferred from experiment | unknown | MEROPS | Mort JS | Menard R et al.:Autocatalytic processing of rec... (C01.032) | 9468501, |
CATL1_HUMAN | 107 | VFQE.|.EPLF | inferred from experiment | unknown | MEROPS | Mort JS | Menard R et al.:Autocatalytic processing of rec... (C01.032) | 9468501, |
CATL1_HUMAN | 112 | LFYE.|.EAPR | inferred from experiment | unknown | MEROPS | Mort JS | Menard R et al.:Autocatalytic processing of rec... (C01.032) | 9468501, |
CATL1_HUMAN | 113 | FYEA.|.APRS | inferred from experiment | unknown | MEROPS | Mort JS | Menard R et al.:Autocatalytic processing of rec... (C01.032) | 9468501, |