TopFIND 4.0

P23246: Splicing factor, proline- and glutamine-rich

General Information

Protein names
- Splicing factor, proline- and glutamine-rich
- 100 kDa DNA-pairing protein
- hPOMp100
- DNA-binding p52/p100 complex, 100 kDa subunit
- Polypyrimidine tract-binding protein-associated-splicing factor {ECO:0000303|PubMed:9848648}
- PSF {ECO:0000303|PubMed:8449401}
- PTB-associated-splicing factor
Gene names SFPQ
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P23246

30

N-termini

7

C-termini

8

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG PGQSGPKPPI 
        70         80         90        100        110        120 
PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP PPPQDSSKPV VAQGPGPAPG 
       130        140        150        160        170        180 
VGSAPPASSS APPATPPTSG APPGSGPGPT PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ 
       190        200        210        220        230        240 
AGGPPPPPAA VPGPGPGPKQ GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPHRGGGE 
       250        260        270        280        290        300 
PRGGRQHHPP YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF 
       310        320        330        340        350        360 
VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA ELDDTPMRGR 
       370        380        390        400        410        420 
QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA VVIVDDRGRS TGKGIVEFAS 
       430        440        450        460        470        480 
KPAARKAFER CSEGVFLLTT TPRPVIVEPL EQLDDEDGLP EKLAQKNPMY QKERETPPRF 
       490        500        510        520        530        540 
AQHGTFEYEY SQRWKSLDEM EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM 
       550        560        570        580        590        600 
RRQEELRRME ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEEQMR RQREESYSRM 
       610        620        630        640        650        660 
GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP ATMSGSMMGS 
       670        680        690        700    
DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG PNKKPRF

Isoforms

- Isoform Short of Splicing factor, proline- and glutamine-rich

Sequence View

        10         20         30         40         50         60 
MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG PGQSGPKPPI 
        70         80         90        100        110        120 
PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP PPPQDSSKPV VAQGPGPAPG 
       130        140        150        160        170        180 
VGSAPPASSS APPATPPTSG APPGSGPGPT PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ 
       190        200        210        220        230        240 
AGGPPPPPAA VPGPGPGPKQ GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPHRGGGE 
       250        260        270        280        290        300 
PRGGRQHHPP YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF 
       310        320        330        340        350        360 
VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA ELDDTPMRGR 
       370        380        390        400        410        420 
QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA VVIVDDRGRS TGKGIVEFAS 
       430        440        450        460        470        480 
KPAARKAFER CSEGVFLLTT TPRPVIVEPL EQLDDEDGLP EKLAQKNPMY QKERETPPRF 
       490        500        510        520        530        540 
AQHGTFEYEY SQRWKSLDEM EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM 
       550        560        570        580        590        600 
RRQEELRRME ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEEQMR RQREESYSRM 
       610        620        630        640        650        660 
GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP ATMSGSMMGS 
       670        680        690        700    
DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG PNKKPRF



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

30 N-termini - 7 C-termini - 8 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)