Q16820: Meprin A subunit beta
Protein names | - Meprin A subunit beta - 3.4.24.63 - Endopeptidase-2 - Meprin B - N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta - PABA peptide hydrolase - PPH beta |
---|---|
Gene names | MEP1B |
Organism | Homo sapiens |
Protease Family | https://www.ebi.ac.uk/merops/cgi-bin/famsum?family= |
Protease ID | |
Chromosome location | |
UniProt ID | Q16820 |
4
N-termini
4
C-termini
3
Cleavages
1705
Substrates
Sequence
10 20 30 40 50 60
MDLWNLSWFL FLDALLVISG LATPENFDVD GGMDQDIFDI NEGLGLDLFE GDIRLDRAQI
70 80 90 100 110 120
RNSIIGEKYR WPHTIPYVLE DSLEMNAKGV ILNAFERYRL KTCIDFKPWA GETNYISVFK
130 140 150 160 170 180
GSGCWSSVGN RRVGKQELSI GANCDRIATV QHEFLHALGF WHEQSRSDRD DYVRIMWDRI
190 200 210 220 230 240
LSGREHNFNT YSDDISDSLN VPYDYTSVMH YSKTAFQNGT EPTIVTRISD FEDVIGQRMD
250 260 270 280 290 300
FSDSDLLKLN QLYNCSSSLS FMDSCSFELE NVCGMIQSSG DNADWQRVSQ VPRGPESDHS
310 320 330 340 350 360
NMGQCQGSGF FMHFDSSSVN VGATAVLESR TLYPKRGFQC LQFYLYNSGS ESDQLNIYIR
370 380 390 400 410 420
EYSADNVDGN LTLVEEIKEI PTGSWQLYHV TLKVTKKFRV VFEGRKGSGA SLGGLSIDDI
430 440 450 460 470 480
NLSETRCPHH IWHIRNFTQF IGSPNGTLYS PPFYSSKGYA FQIYLNLAHV TNAGIYFHLI
490 500 510 520 530 540
SGANDDQLQW PCPWQQATMT LLDQNPDIRQ RMSNQRSITT DPFMTTDNGN YFWDRPSKVG
550 560 570 580 590 600
TVALFSNGTQ FRRGGGYGTS AFITHERLKS RDFIKGDDVY ILLTVEDISH LNSTQIQLTP
610 620 630 640 650 660
APSVQDLCSK TTCKNDGVCT VRDGKAECRC QSGEDWWYMG ERCEKRGSTR DTIVIAVSST
670 680 690 700
VAVFALMLII TLVSVYCTRK KYRERMSSNR PNLTPQNQHA F
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 4 C-termini - 3 Cleavages - 1705 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q16820-23-unknown | TPENFD... | 23 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q16820-33-unknown | MDQDIF... | 33 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462038 | |||
Q16820-62-unknown | NSIIGE... | 62 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q16820-62-unknown | NSIIGE... | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16477 | |||
Q16820-62-unknown | NSIIGE... | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16382 | |||
Q16820-81-unknown | DSLEMN... | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19605 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...RAQIRN | 61 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16477 | |||
...RAQIRN | 61 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16382 | |||
...PYVLED | 80 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19605 | |||
...ANCDRI | 146 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462038 | |||
...NQHAF | 701 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
KLK5_HUMAN | 61 | QIRN.|.NSII | inferred from experiment | unknown | MEROPS | Goettig P | Debela M et al.:Structures and specificity of t... (S01.251) | 18627343, |
KLK4_HUMAN | 61 | QIRN.|.NSII | inferred from experiment | unknown | MEROPS | Goettig P | Debela M et al.:Structures and specificity of t... (S01.251) | 18627343, |
MEP1B_HUMAN | 80 | VLED.|.DSLE | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |