P45880: Voltage-dependent anion-selective channel protein 2

General Information

Protein names	- Voltage-dependent anion-selective channel protein 2 - VDAC-2 - hVDAC2 - Outer mitochondrial membrane protein porin 2
Gene names	VDAC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P45880

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Voltage-dependent anion-selective channel protein 2 - Isoform 2 of Voltage-dependent anion-selective channel protein 2

Sequence View

        10         20         30         40         50         60
MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV EFSTSGSSNT
        70         80         90        100        110        120
DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED QICQGLKLTF DTTFSPNTGK
       130        140        150        160        170        180
KSGKIKSSYK RECINLGCDV DFDFAGPAIH GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF
       190        200        210        220        230        240
AVGYRTGDFQ LHTNVNDGTE FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP
       250        260        270        280        290
TASISAKVNN SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA         10         20         30         40         50         60
MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV EFSTSGSSNT
        70         80         90        100        110        120
DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED QICQGLKLTF DTTFSPNTGK
       130        140        150        160        170        180
KSGKIKSSYK RECINLGCDV DFDFAGPAIH GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF
       190        200        210        220        230        240
AVGYRTGDFQ LHTNVNDGTE FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP
       250        260        270        280        290
TASISAKVNN SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P45880-2-unknown	MATHGQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45880-2-Acetylation	ATHGQT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45880-12-unknown	MCIPPS...	12		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94087
P45880-62-unknown	TGKVTG...	62		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17652
P45880-62-unknown	TGKVTG...	62		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139296
P45880-111-unknown	DTTFSP...	111		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19110
P45880-111-unknown	DTTFSP...	111		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142410

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SSNTDT	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17652
...SSNTDT	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122371
...LKLTFD	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19110
...LKLTFD	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125603
...LELEA	294	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LELEA	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89705

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	61	NTDT.\|.TGKV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	110	LTFD.\|.DTTF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)