Q9H1E3: Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

General Information

Protein names	- Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 - P1
Gene names	NUCKS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H1E3

10 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPTKKIRSS PREAKNKRRS GKNSQEDSED
        70         80         90        100        110        120
SEDKDVKTKK DDSHSAEDSE DEKEDHKNVR QQRQAASKAA SKQREMLMED VGSEEEQEEE
       130        140        150        160        170        180
DEAPFQEKDS GSDEDFLMED DDDSDYGSSK KKNKKMVKKS KPERKEKKMP KPRLKATVTP
       190        200        210        220        230        240
SPVKGKGKVG RPTASKASKE KTPSPKEEDE EPESPPEKKT STSPPPEKSG DEGSEDEAPS

GED

Isoforms

- Isoform 2 of Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H1E3-1-unknown	MSRPVR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H1E3-9-	KVVDYS...	9		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H1E3-80-unknown	EDEKED...	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19787
Q9H1E3-80-unknown	EDEKED...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138319
Q9H1E3-81-unknown	DEKEDH...	81	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19789
Q9H1E3-81-unknown	DEKEDH...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138411
Q9H1E3-130-unknown	SGSDED...	130	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176078
Q9H1E3-130-	SGSDED...	130		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H1E3-174-	LKATVT...	174		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9H1E3-174-	LKATVT...	174		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H1E3-174-unknown	LKATVT...	174		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H1E3-174-unknown	LKATVT...	174	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159997
Q9H1E3-176-unknown	ATVTPS...	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6771
Q9H1E3-176-unknown	ATVTPS...	176		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H1E3-176-unknown	ATVTPS...	176	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144128
Q9H1E3-176-	ATVTPS...	176		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9H1E3-176-	ATVTPS...	176		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9H1E3-176-	ATVTPS...	176		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H1E3-176-	ATVTPS...	176		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9H1E3-176-	ATVTPS...	176		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SAEDSE	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19787
...SAEDSE	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121356
...AEDSED	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19789
...AEDSED	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121452
...KPRLKA	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6771
...KPRLKA	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127379
...PSGED	243	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSGED	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79111

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	79	EDSE.\|.EDEK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	80	DSED.\|.DEKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	175	RLKA.\|.ATVT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)