P52926: High mobility group protein HMGI-C

General Information

Protein names	- High mobility group protein HMGI-C - High mobility group AT-hook protein 2
Gene names	HMGA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52926

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP
70 80 90 100
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED

Isoforms

- Isoform 2 of High mobility group protein HMGI-C - Isoform 3 of High mobility group protein HMGI-C - Isoform 4 of High mobility group protein HMGI-C - Isoform 5 of High mobility group protein HMGI-C - Isoform 6 of High mobility group protein HMGI-C

Sequence View

        10         20         30         40         50         60
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP
        70         80         90        100
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED         10         20         30         40         50         60
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP
        70         80         90        100
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED         10         20         30         40         50         60
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP
        70         80         90        100
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED         10         20         30         40         50         60
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP
        70         80         90        100
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED         10         20         30         40         50         60
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP
        70         80         90        100
SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P52926-2-unknown	MSARGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P52926-1-unknown	MSARGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77080
P52926-1-unknown	MSARGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77081
P52926-1-unknown	MSARGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77082
P52926-1-unknown	MSARGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77083
P52926-1-unknown	MSARGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77084
P52926-2-Acetylation	SARGEG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P52926-2-Acetylation	SARGEG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110346
P52926-2-Acetylation	SARGEG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110347
P52926-2-Acetylation	SARGEG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110348
P52926-2-Acetylation	SARGEG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110349
P52926-2-Acetylation	SARGEG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110350
P52926-18-unknown	QPAAPA...	18		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19192
P52926-18-unknown	QPAAPA...	18		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136749
P52926-18-unknown	QPAAPA...	18		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136750
P52926-18-unknown	QPAAPA...	18		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136751
P52926-18-unknown	QPAAPA...	18		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136752
P52926-18-unknown	QPAAPA...	18		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136753

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TSAQGQ	17	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19192
	...SAEED	109	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	17	AQGQ.\|.QPAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)