P48735: Isocitrate dehydrogenase [NADP], mitochondrial

General Information

Protein names	- Isocitrate dehydrogenase NADP], mitochondrial - IDH - 1.1.1.42 - ICD-M - IDP - NADP(+)-specific ICDH - Oxalosuccinate decarboxylase
Gene names	IDH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P48735

6 N-termini

2 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR
        70         80         90        100        110        120
IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS ALATQKYSVA VKCATITPDE
       130        140        150        160        170        180
ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK
       190        200        210        220        230        240
ATDFVADRAG TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI
       250        260        270        280        290        300
QKKWPLYMST KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS
       310        320        330        340        350        360
SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK
       370        380        390        400        410        420
GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH
       430        440        450
GLSNVKLNEH FLNTTDFLDT IKSNLDRALG RQ

Isoforms

- Isoform 2 of Isocitrate dehydrogenase [NADP], mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P48735-20-unknown	AWAPAA...	20		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P48735-20-	AWAPAA...	20		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P48735-40-unknown	ADKRIK...	40	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P48735-40-unknown	ADKRIK...	40	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P48735-53-unknown	MDGDEM...	53	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446147
P48735-131-unknown	MWKSPN...	131	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438457
P48735-344-unknown	AEAAHG...	344	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5903
P48735-344-unknown	AEAAHG...	344	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7486
P48735-344-unknown	AEAAHG...	344	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19138

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKTIEA	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5903
...GKTIEA	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7486
...GKTIEA	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19138
...ALGRQ	452	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	343	TIEA.\|.AEAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	343	TIEA.\|.AEAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	343	TIEA.\|.AEAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)