P78371: T-complex protein 1 subunit beta

General Information

Protein names	- T-complex protein 1 subunit beta - TCP-1-beta - CCT-beta
Gene names	CCT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78371

22 N-termini

9 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK ILLSSGRDAS
        70         80         90        100        110        120
LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT SVTVLAAELL REAESLIAKK
       130        140        150        160        170        180
IHPQTIIAGW REATKAAREA LLSSAVDHGS DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT
       190        200        210        220        230        240
KLAVEAVLRL KGSGNLEAIH IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA
       250        260        270        280        290        300
NTGMDTDKIK IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
       310        320        330        340        350        360
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE EVMIGEDKLI
       370        380        390        400        410        420
HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT VKDSRTVYGG GCSEMLMAHA
       430        440        450        460        470        480
VTQLANRTPG KEAVAMESYA KALRMLPTII ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM
       490        500        510        520        530
REGTIGDMAI LGITESFQVK RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC

Isoforms

- Isoform 2 of T-complex protein 1 subunit beta

Sequence View

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Protein Neighborhood

Domains & Features

22 N-termini - 9 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P78371-2-unknown	MASLSL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78371-2-Acetylation	ASLSLA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78371-2-Acetylation	ASLSLA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P78371-2-Acetylation	ASLSLA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P78371-2-Acetylation	ASLSLA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P78371-2-Acetylation	ASLSLA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P78371-48-unknown	MDKILL...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91750
P78371-139-unknown	EALLSS...	139		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P78371-139-unknown	EALLSS...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197523
P78371-143-unknown	SSAVDH...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7688
P78371-143-unknown	SSAVDH...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6174
P78371-143-unknown	SSAVDH...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3923
P78371-143-unknown	SSAVDH...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142157
P78371-144-unknown	SAVDHG...	144		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7690
P78371-144-unknown	SAVDHG...	144		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6176
P78371-144-unknown	SAVDHG...	144		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142227
P78371-215-unknown	DEGFLL...	215		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19294
P78371-215-unknown	DEGFLL...	215		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145446
P78371-241-unknown	NTGMDT...	241		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7692
P78371-241-unknown	NTGMDT...	241		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6178
P78371-241-unknown	NTGMDT...	241		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3925
P78371-241-unknown	NTGMDT...	241		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146374
P78371-258-unknown	VDSTAK...	258		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165887
P78371-258-	VDSTAK...	258			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P78371-260-unknown	STAKVA...	260		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178165
P78371-260-	STAKVA...	260			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P78371-308-unknown	GVMAIE...	308		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173786
P78371-308-	GVMAIE...	308			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78371-326-unknown	VTGGEI...	326		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3927
P78371-326-unknown	VTGGEI...	326		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149317
P78371-328-unknown	GGEIAS...	328		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6180
P78371-328-unknown	GGEIAS...	328		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149360
P78371-333-unknown	STFDHP...	333		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7694
P78371-333-unknown	STFDHP...	333		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6182
P78371-333-unknown	STFDHP...	333		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149480
P78371-377-	GATQQI...	377			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78371-377-unknown	GATQQI...	377		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172298
P78371-414-unknown	EMLMAH...	414		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19296
P78371-414-unknown	EMLMAH...	414		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151348
P78371-467-unknown	AAHSEG...	467		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168480
P78371-467-	AAHSEG...	467			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P78371-467-	AAHSEG...	467			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78371-467-	AAHSEG...	467			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...REALLS	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7688
...REALLS	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6174
...REALLS	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3923
...REALLS	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125343
...EALLSS	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7690
...EALLSS	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6176
...EALLSS	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125415
...ADSYLD	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19294
...ADSYLD	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128741
...KILIAN	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7692
...KILIAN	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6178
...KILIAN	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3925
...KILIAN	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129678
...ERLALV	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3927
...ERLALV	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132702
...LALVTG	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6180
...LALVTG	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132744
...GGEIAS	332	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7694
...GGEIAS	332	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6182
...GGEIAS	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132864
...GGGCSE	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19296
...GGGCSE	413	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134750
...DHHPC	535	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DHHPC	535	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87368

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	142	ALLS.\|.SSAV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	142	ALLS.\|.SSAV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	142	ALLS.\|.SSAV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	143	LLSS.\|.SAVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	143	LLSS.\|.SAVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	214	SYLD.\|.DEGF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	240	LIAN.\|.NTGM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	240	LIAN.\|.NTGM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	240	LIAN.\|.NTGM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	325	LALV.\|.VTGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	327	LVTG.\|.GGEI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	332	EIAS.\|.STFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	332	EIAS.\|.STFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	413	GCSE.\|.EMLM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)