P23381: Tryptophan--tRNA ligase, cytoplasmic

General Information

Protein names	- Tryptophan--tRNA ligase, cytoplasmic - 6.1.1.2 {ECO:0000269\|PubMed:1761529, ECO:0000269\|PubMed:28369220} - Interferon-induced protein 53 - IFP53 - Tryptophanyl-tRNA synthetase - TrpRS - hWRS - T1-TrpRS - T2-TrpRS
Gene names	WARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23381

9 N-termini

26 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tryptophan--tRNA ligase, cytoplasmic - Isoform 2 of Tryptophan--tRNA ligase, cytoplasmic

Sequence View

        10         20         30         40         50         60
MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA
        70         80         90        100        110        120
DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI
       130        140        150        160        170        180
ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT
       190        200        210        220        230        240
KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY
       250        260        270        280        290        300
MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR
       310        320        330        340        350        360
TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF
       370        380        390        400        410        420
LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY
       430        440        450        460        470
TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q         10         20         30         40         50         60
MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA
        70         80         90        100        110        120
DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI
       130        140        150        160        170        180
ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT
       190        200        210        220        230        240
KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY
       250        260        270        280        290        300
MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR
       310        320        330        340        350        360
TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF
       370        380        390        400        410        420
LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY
       430        440        450        460        470
TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 26 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P23381-2-unknown	PNSEPA...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23381-2-unknown	PNSEPA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P23381-2-unknown	PNSEPA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P23381-2-unmodified	PNSEPA...	2		other		CNRS/ISV	Large_scale_NTA_Human
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000351481
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000339485
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451887
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451490
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451251
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451599
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452519
P23381-42-unknown	MLVSLK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451544
P23381-48-unknown	MSYKAA...	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91328
P23381-71-unknown	SNHGPD...	71	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23381-71-unknown	SNHGPD...	71	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115778
P23381-83-unknown	DFVDPW...	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18931
P23381-83-unknown	DFVDPW...	83	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138071
P23381-84-	FVDPWT...	84		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P23381-84-	FVDPWT...	84		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P23381-84-	FVDPWT...	84		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P23381-84-	FVDPWT...	84		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P23381-84-unknown	FVDPWT...	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171250
P23381-94-unknown	SAKGID...	94	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23381-94-unknown	SAKGID...	94	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115849

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ELVRSL	25	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452358
...GNASKD	33	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452379
...KAAAGE	55	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450623
...AGEDYK	58	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451777
...AGEDYK	58	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451377
...KADCPP	63	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451953
...PGNPAP	68	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450978
...PGNPAP	68	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113760
...NPAPTS	70	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451027
...NPAPTS	70	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113758
...PAPTSN	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451894
...PAPTSN	71	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113756
...TEAEED	82	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18931
...TEAEED	82	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt121087
...EDFVDP	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450563
...EDFVDP	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113754
...SSAKGI	97	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451716
...SSAKGI	97	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113752
...YDKLIV	104	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451906
...YDKLIV	104	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113750
...LIVRFG	107	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452550
...LIVRFG	107	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113748
...SKIDKE	114	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451402
...SKIDKE	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113746
...IERATG	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451469
...IERATG	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113744
...SHRDMN	143	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450934
...SHRDMN	143	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113742
...VLDAYE	150	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451349
...VLDAYE	150	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113740
...DAYENK	152	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450427
...DAYENK	152	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113738
...FIFTKW	181	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451544
...FIFTKW	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113736
...PLVIQM	194	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452519
...PLVIQM	194	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113734
...LVIQMT	195	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451599
...LVIQMT	195	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113732
...LDQAYS	212	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450500
...LDQAYS	212	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113730
...FNQVKG	264	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451251
...FNQVKG	264	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113728
...VKGIFG	267	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451490
...VKGIFG	267	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt113726
...SFDFQ	471		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SFDFQ	471	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SFDFQ	471	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt86946
...SFDFQ	471		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SFDFQ	471		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	82	AEED.\|.DFVD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)