O00515: Ladinin-1

General Information

Protein names	- Ladinin-1 - Lad-1 - Linear IgA disease antigen - LADA
Gene names	LAD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00515

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDEAPRLSQ NGDRQASASE
        70         80         90        100        110        120
RLPSVEEAEV PKPLPPASKD EDEDIQSILR TRQERRQRRQ VVEAAQAPIQ ERLEAEEGRN
       130        140        150        160        170        180
SLSPVQATQK PLVSKKELEI PPRRRLSREQ RGPWALEEES LVGREPEERK KGVPEKSPVL
       190        200        210        220        230        240
EKSSMPKKTA PEKSLVSDKT SISEKVLASE KTSLSEKIAV SEKRNSSEKK SVLEKTSVSE
       250        260        270        280        290        300
KSLAPGMALG SGRRLVSEKA SIFEKALASE KSPTADAKPA PKRATASEQP LAQEPPASGG
       310        320        330        340        350        360
SPATTKEQRG RALPGKNLPS LAKQGASDPP TVASRLPPVT LQVKIPSKEE EADMSSPTQR
       370        380        390        400        410        420
TYSSSLKRSS PRTISFRMKP KKENSETTLT RSASMKLPDN TVKLGEKLER YHTAIRRSES
       430        440        450        460        470        480
VKSRGLPCTE LFVAPVGVAS KRHLFEKELA GQSRAEPASS RKENLRLSGV VTSRLNLWIS
       490        500        510
RTQESGDQDP QEAQKASSAT ERTQWGQKSD SSLDAEV

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00515-1-unknown	MAVSRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00515-294-unknown	EPPASG...	294	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18204
O00515-294-unknown	EPPASG...	294	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16862
O00515-350-unknown	EEADMS...	350	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422687

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QPLAQE	293	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18204
...QPLAQE	293	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16862
...LDAEV	517		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LDAEV	517	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LDAEV	517		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	293	LAQE.\|.EPPA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	293	LAQE.\|.EPPA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)