P13693: Translationally-controlled tumor protein

General Information

Protein names	- Translationally-controlled tumor protein - TCTP - Fortilin - Histamine-releasing factor - HRF - p23
Gene names	TPT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P13693

13 N-termini

10 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE
        70         80         90        100        110        120
GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE
       130        140        150        160        170
QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC

Isoforms

- Isoform 2 of Translationally-controlled tumor protein

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 10 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P13693-1-unknown	MIIYRD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13693-1-unknown	MIIYRD...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P13693-1-	MIIYRD...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P13693-1-	MIIYRD...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P13693-1-	MIIYRD...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P13693-1-	MIIYRD...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P13693-1-	MIIYRD...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P13693-1-	MIIYRD...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P13693-11-unknown	DEMFSD...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18724
P13693-11-unknown	DEMFSD...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17327
P13693-13-unknown	EMFSDI...	12	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000368350
P13693-13-unknown	EMFSDI...	12	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11203
P13693-14-unknown	FSDIYK...	14	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11204
P13693-25-unknown	DGLCLE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18725
P13693-25-unknown	DGLCLE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17328
P13693-29-unknown	LEVEGK...	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11205
P13693-30-unknown	EVEGKM...	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11206
P13693-31-unknown	VEGKMV...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11207
P13693-35-unknown	MVSRTE...	35	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91772
P13693-35-unknown	MVSRTE...	35	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000368345
P13693-35-unknown	MVSRTE...	35	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000368344
P13693-52-unknown	ASAEGP...	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11208
P13693-52-unknown	ASAEGP...	52	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136737
P13693-111-	VKPFMT...	111		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P13693-111-unknown	VKPFMT...	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177277

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DLISHD	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18724
...DLISHD	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17327
...ISHDEM	12	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11203
...SHDEMF	13	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11204
...IREIAD	24	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18725
...IREIAD	24	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17328
...ADGLCL	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11205
...DGLCLE	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11206
...GLCLEV	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11207
...LIGGNA	51	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11208
...YMIFFK	163	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433738
...YMIFFK	163	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt109923
...EMEKC	172	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EMEKC	172	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt87390
...EMEKC	172		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	10	ISHD.\|.DEMF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	10	ISHD.\|.DEMF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	12	HDEM.\|.MFSD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	13	DEMF.\|.FSDI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	24	EIAD.\|.DGLC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	24	EIAD.\|.DGLC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	28	GLCL.\|.LEVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	29	LCLE.\|.EVEG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	30	CLEV.\|.VEGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	51	GGNA.\|.ASAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)