P62937: Peptidyl-prolyl cis-trans isomerase A

General Information

Protein names	- Peptidyl-prolyl cis-trans isomerase A - PPIase A - 5.2.1.8 {ECO:0000269\|PubMed:20676357} - Cyclophilin A - Cyclosporin A-binding protein - Rotamase A - Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Gene names	PPIA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62937

23 N-termini

11 C-termini

15 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF
        70         80         90        100        110        120
MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE
       130        140        150        160
WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE

Isoforms

- Isoform 2 of Peptidyl-prolyl cis-trans isomerase A

Sequence View

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Protein Neighborhood

Domains & Features

23 N-termini - 11 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62937-1-Acetylation	MVNPTV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62937-1-Acetylation	MVNPTV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P62937-1-Acetylation	MVNPTV...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62937-1-Acetylation	MVNPTV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P62937-1-unknown	MVNPTV...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P62937-1-	MVNPTV...	1			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62937-2-Acetylation	VNPTVF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62937-2-Acetylation	VNPTVF...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62937-2-unknown	VNPTVF...	2		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16806
P62937-2-unknown	VNPTVF...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P62937-2-unknown	VNPTVF...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62937-2-	VNPTVF...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62937-2-	VNPTVF...	2			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62937-8-unknown	FDIAVD...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19972
P62937-9-unknown	DIAVDG...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7659
P62937-9-unknown	DIAVDG...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6142
P62937-10-unknown	IAVDGE...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7660
P62937-10-unknown	IAVDGE...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6143
P62937-10-	IAVDGE...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-11-	AVDGEP...	11			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-20-acetylation	VSFELF...	20	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62937-22-unknown	FELFAD...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17796
P62937-27-unknown	DKVPKT...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19271
P62937-27-unknown	DKVPKT...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17797
P62937-28-unknown	KVPKTA...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19272
P62937-28-unknown	KVPKTA...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17798
P62937-38-	ALSTGE...	38			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-38-	ALSTGE...	38			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62937-38-	ALSTGE...	38			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62937-39-unknown	LSTGEK...	39		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19273
P62937-39-unknown	LSTGEK...	39		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8267
P62937-61-unknown	MCQGGD...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000427976
P62937-61-unknown	MCQGGD...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430817
P62937-62-unknown	CQGGDF...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6144
P62937-62-unknown	CQGGDF...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7661
P62937-72-	GTGGKS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62937-72-	GTGGKS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-72-	GTGGKS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62937-72-	GTGGKS...	72			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62937-72-	GTGGKS...	72			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62937-77-	SIYGEK...	77			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62937-77-	SIYGEK...	77			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62937-77-	SIYGEK...	77			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62937-77-	SIYGEK...	77			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62937-77-	SIYGEK...	77			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62937-80-	GEKFED...	80			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62937-101-	ANAGPN...	101			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...NPTVFF	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19972
...PTVFFD	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7659
...PTVFFD	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6142
...TVFFDI	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7660
...TVFFDI	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6143
...LGRVSF	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17796
...FELFAD	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19271
...FELFAD	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17797
...ELFADK	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19272
...ELFADK	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17798
...ENFRAL	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19273
...ENFRAL	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8267
...IPGFMC	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6144
...IPGFMC	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7661
...AKTEWL	121	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405975
...CGQLE	165	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...CGQLE	165		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...CGQLE	165		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...CGQLE	165		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...CGQLE	165		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MAP2_HUMAN	1	.\|.VNPT	inferred from experiment	unknown	MEROPS	Wang J	Warder SE et al.:Discovery, identification, and ... (M24.002)	18828628,
MMP11_HUMAN	7	TVFF.\|.FDIA	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> PPIA_HUMAN @7
CATS_HUMAN	8	VFFD.\|.DIAV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	8	VFFD.\|.DIAV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	9	FFDI.\|.IAVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	9	FFDI.\|.IAVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	21	RVSF.\|.FELF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	26	LFAD.\|.DKVP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	26	LFAD.\|.DKVP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	27	FADK.\|.KVPK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	27	FADK.\|.KVPK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	38	FRAL.\|.LSTG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CBPA6_HUMAN	38	FRAL.\|.LSTG	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Substrate specificity of human ... (M14.018)	20855895,
CATL1_HUMAN	61	GFMC.\|.CQGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	61	GFMC.\|.CQGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)