P50579: Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}

General Information

Protein names	- Methionine aminopeptidase 2 {ECO:0000255\|HAMAP-Rule:MF_03175} - MAP 2 {ECO:0000255\|HAMAP-Rule:MF_03175} - MetAP 2 {ECO:0000255\|HAMAP-Rule:MF_03175} - 3.4.11.18 {ECO:0000255\|HAMAP-Rule:MF_03175} - Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255\|HAMAP-Rule:MF_03175} - p67 {ECO:0000255\|HAMAP-Rule:MF_03175} - p67eIF2 {ECO:0000255\|HAMAP-Rule:MF_03175} - Peptidase M {ECO:0000255\|HAMAP-Rule:MF_03175}
Gene names	METAP2
Organism	Homo sapiens
Protease Family	M24.002
Protease ID	M24.002
Chromosome location
UniProt ID	P50579

6 N-termini

5 C-termini

2 Cleavages

5 Substrates

Sequence

Isoforms

- Isoform 2 of Methionine aminopeptidase 2 - Isoform 3 of Methionine aminopeptidase 2

Sequence View

        10         20         30         40         50         60
MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA AGEQEPDKES
        70         80         90        100        110        120
GASVDEVARQ LERSALEDKE RDEDDEDGDG DGDGATGKKK KKKKKKRGPK VQTDPPSVPI
       130        140        150        160        170        180
CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR
       190        200        210        220        230        240
KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT
       250        260        270        280        290        300
VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDTLLKAV KDATNTGIKC AGIDVRLCDV
       310        320        330        340        350        360
GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGQYRIHA GKTVPIVKGG EATRMEEGEV
       370        380        390        400        410        420
YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL
       430        440        450        460        470
DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY         10         20         30         40         50         60
MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA AGEQEPDKES
        70         80         90        100        110        120
GASVDEVARQ LERSALEDKE RDEDDEDGDG DGDGATGKKK KKKKKKRGPK VQTDPPSVPI
       130        140        150        160        170        180
CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR
       190        200        210        220        230        240
KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT
       250        260        270        280        290        300
VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDTLLKAV KDATNTGIKC AGIDVRLCDV
       310        320        330        340        350        360
GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGQYRIHA GKTVPIVKGG EATRMEEGEV
       370        380        390        400        410        420
YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL
       430        440        450        460        470
DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 2 Cleavages - 5 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50579-2-unknown	MAGVEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50579-2-Acetylation	AGVEEV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50579-45-	SKGPSA...	45			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P50579-58-unknown	KESGAS...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11617
P50579-74-unknown	SALEDK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10094
P50579-423-	LGESKY...	423			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EQEPDK	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11617
...RQLERS	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10094
...FPKGQE	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448370
...EKLEDC	202	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449004
...RGDDY	478	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	57	EPDK.\|.KESG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	73	LERS.\|.SALE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SH3L1_HUMAN	1	.\|.VIRV	inferred from experiment	unknown	MEROPS	Wang J	Warder SE et al.:Discovery, identification, and ... (M24.002)	18828628,
G3P_HUMAN	1	.\|.GKVK	inferred from experiment	unknown	MEROPS	Wang J	Warder SE et al.:Discovery, identification, and ... (M24.002)	18828628,
THIO_HUMAN	1	.\|.VKQI	inferred from experiment	unknown	MEROPS	Wang J	Warder SE et al.:Discovery, identification, and ... (M24.002)	18828628,
EF2_HUMAN	1	.\|.VNFT	inferred from experiment	unknown	MEROPS	Wang J	Warder SE et al.:Discovery, identification, and ... (M24.002)	18828628,
PPIA_HUMAN	1	.\|.VNPT	inferred from experiment	unknown	MEROPS	Wang J	Warder SE et al.:Discovery, identification, and ... (M24.002)	18828628,