P24347: Stromelysin-3
Protein names | - Stromelysin-3 - SL-3 - ST3 - 3.4.24.- - Matrix metalloproteinase-11 - MMP-11 |
---|---|
Gene names | MMP11 |
Organism | Homo sapiens |
Protease Family | M10.007 |
Protease ID | M10.007 |
Chromosome location | |
UniProt ID | P24347 |
4
N-termini
4
C-termini
7
Cleavages
28
Substrates
Sequence
10 20 30 40 50 60
MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP WHAALPSSPA
70 80 90 100 110 120
PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL SGGRWEKTDL TYRILRFPWQ
130 140 150 160 170 180
LVQEQVRQTM AEALKVWSDV TPLTFTEVHE GRADIMIDFA RYWHGDDLPF DGPGGILAHA
190 200 210 220 230 240
FFPKTHREGD VHFDYDETWT IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR
250 260 270 280 290 300
YPLSLSPDDC RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA
310 320 330 340 350 360
VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA QGHIWFFQGA
370 380 390 400 410 420
QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI YFFRGRDYWR FHPSTRRVDS
430 440 450 460 470 480
PVPRRATDWR GVPSEIDAAF QDADGYAYFL RGRLYWKFDP VKVKALEGFP RLVGPDFFGC
AEPANTFL
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 4 C-termini - 7 Cleavages - 28 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P24347-32-unknown | RALPPD... | 32 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26890 | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9760 | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27035 | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27334 | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26620 | |||
P24347-98-unknown | FVLSGG... | 98 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P24347-285-unknown | LEPDAP... | 285 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19963 | |||
P24347-440-unknown | FQDADG... | 440 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19964 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...NRQKRF | 97 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26890 | |||
...NRQKRF | 97 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9760 | |||
...NRQKRF | 97 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27035 | |||
...NRQKRF | 97 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27334 | |||
...NRQKRF | 97 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26620 | |||
...NEIAPL | 284 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19963 | |||
...EIDAAF | 439 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19964 | |||
...ANTFL | 488 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PCSK4_HUMAN | 97 | QKRF.|.FVLS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
FURIN_HUMAN | 97 | QKRF.|.FVLS | inferred from experiment | unknown | MEROPS | Weiss SJ | Pei D et al.:Furin-dependent intracellular a... (S08.071) | 7746327, |
PCSK5_HUMAN | 97 | QKRF.|.FVLS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
PCSK7_HUMAN | 97 | QKRF.|.FVLS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
NEC2_HUMAN | 97 | QKRF.|.FVLS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
MMP11_HUMAN | 284 | IAPL.|.LEPD | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> MMP11_HUMAN @284 | ||
MMP11_HUMAN | 439 | DAAF.|.FQDA | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> MMP11_HUMAN @439 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PPIA_HUMAN | 7 | TVFF.|.FDIA | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> PPIA_HUMAN @7 | ||
RS21_HUMAN | 7 | AGEF.|.FVDL | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> RS21_HUMAN @7 | ||
LXN_HUMAN | 19 | AQNY.|.YINY | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> LXN_HUMAN @19 | ||
HSPB1_HUMAN | 62 | PAAI.|.IESP | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> HSPB1_HUMAN @62 | ||
CLUS-Isoform3_HUMAN | 91 | SPAF.|.FQHP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19958 | ||
ACTA_HUMAN | 106 | PTLL.|.LTEA | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> ACTA_HUMAN @106 | ||
IBP1_HUMAN | 165 | ALHV.|.VTNI | inferred from experiment | unknown | MEROPS | Martinez-A C | Manes S et al.:Identification of insulin-like ... (M10.007) | 9325295, |
CLUS-Isoform4_HUMAN | 233 | SPAF.|.FQHP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19958 | ||
ACTA_HUMAN | 237 | SSSL.|.LEKS | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> ACTA_HUMAN @237 | ||
CLUS_HUMAN | 266 | SPAF.|.FQHP | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> CLUS_HUMAN @266 | ||
CLUS-Isoform5_HUMAN | 277 | SPAF.|.FQHP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19958 | ||
MMP11_HUMAN | 284 | IAPL.|.LEPD | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> MMP11_HUMAN @284 | ||
ACTB_HUMAN | 296 | YANT.|.TVLS | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> ACTB_HUMAN @296 | ||
PTBP1_HUMAN | 305 | NVHG.|.GALA | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> PTBP1_HUMAN @305 | ||
RD23A-Isoform3_HUMAN | 311 | QMNY.|.YIQV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19967 | ||
RD23A_HUMAN | 312 | QMNY.|.YIQV | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> RD23A_HUMAN @312 | ||
CLUS-Isoform2_HUMAN | 318 | SPAF.|.FQHP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19958 | ||
A2AP-Isoform2_HUMAN | 331 | AAAA.|.ATSI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19953 | ||
A2AP-Isoform2_HUMAN | 333 | AATS.|.SIAM | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19955 | ||
A1AT_HUMAN | 374 | AGAM.|.MFLE | inferred from experiment | unknown | MEROPS | Weiss SJ | Pei D et al.:Hydrolytic inactivation of a br... (M10.007) | 7523394, |
A2AP_HUMAN | 395 | AAAA.|.ATSI | inferred from experiment | unknown | MEROPS | Weiss SJ | Pei D et al.:Hydrolytic inactivation of a br... (M10.007) | 7523394, |
A2AP_HUMAN | 397 | AATS.|.SIAM | inferred from experiment | unknown | MEROPS | Weiss SJ | Pei D et al.:Hydrolytic inactivation of a br... (M10.007) | 7523394, |
STAM2_HUMAN | 417 | AQSY.|.YSLG | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> STAM2_HUMAN @417 | ||
STIP1_HUMAN | 420 | EECI.|.IQLE | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> STIP1_HUMAN @420 | ||
MMP11_HUMAN | 439 | DAAF.|.FQDA | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> MMP11_HUMAN @439 | ||
HS90B_HUMAN | 662 | ETAL.|.LLSS | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> HS90B_HUMAN @662 | ||
HS90A_HUMAN | 670 | ETAL.|.LLSS | inferred from experiment | unknown | MEROPS | Merops MMP11_HUMAN -> HS90A_HUMAN @670 | ||
HS90A-Isoform2_HUMAN | 792 | ETAL.|.LLSS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19950 |