P10909: Clusterin

General Information

Protein names	- Clusterin - Aging-associated gene 4 protein {ECO:0000303\|Ref.20} - Apolipoprotein J {ECO:0000303\|PubMed:2387851} - Apo-J - Complement cytolysis inhibitor {ECO:0000303\|PubMed:2780565} - CLI {ECO:0000303\|PubMed:2780565} - Complement-associated protein SP-40,40 {ECO:0000303\|PubMed:1903064} - Ku70-binding protein 1 - NA1/NA2 {ECO:0000303\|PubMed:1903064} - Sulfated glycoprotein 2 {ECO:0000303\|PubMed:1924317} - SGP-2 {ECO:0000303\|PubMed:1924317} - Testosterone-repressed prostate message 2 {ECO:0000250\|UniProtKB:P05371} - TRPM-2 {ECO:0000303\|PubMed:8181474} - Clusterin beta chain - ApoJalpha - Complement cytolysis inhibitor a chain - Clusterin alpha chain - ApoJbeta - Complement cytolysis inhibitor b chain
Gene names	CLU
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10909

23 N-termini

16 C-termini

20 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Clusterin - Isoform 3 of Clusterin - Isoform 4 of Clusterin - Isoform 5 of Clusterin - Isoform 6 of Clusterin

Sequence View

        10         20         30         40         50         60
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
        70         80         90        100        110        120
EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
       130        140        150        160        170        180
CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF
       190        200        210        220        230        240
SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF
       250        260        270        280        290        300
HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD
       310        320        330        340        350        360
QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE
       370        380        390        400        410        420
QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP
       430        440
VEVSRKNPKF METVAEKALQ EYRKKHREE         10         20         30         40         50         60
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
        70         80         90        100        110        120
EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
       130        140        150        160        170        180
CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF
       190        200        210        220        230        240
SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF
       250        260        270        280        290        300
HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD
       310        320        330        340        350        360
QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE
       370        380        390        400        410        420
QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP
       430        440
VEVSRKNPKF METVAEKALQ EYRKKHREE         10         20         30         40         50         60
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
        70         80         90        100        110        120
EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
       130        140        150        160        170        180
CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF
       190        200        210        220        230        240
SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF
       250        260        270        280        290        300
HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD
       310        320        330        340        350        360
QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE
       370        380        390        400        410        420
QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP
       430        440
VEVSRKNPKF METVAEKALQ EYRKKHREE         10         20         30         40         50         60
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
        70         80         90        100        110        120
EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
       130        140        150        160        170        180
CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF
       190        200        210        220        230        240
SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF
       250        260        270        280        290        300
HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD
       310        320        330        340        350        360
QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE
       370        380        390        400        410        420
QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP
       430        440
VEVSRKNPKF METVAEKALQ EYRKKHREE         10         20         30         40         50         60
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
        70         80         90        100        110        120
EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
       130        140        150        160        170        180
CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF
       190        200        210        220        230        240
SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF
       250        260        270        280        290        300
HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD
       310        320        330        340        350        360
QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE
       370        380        390        400        410        420
QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP
       430        440
VEVSRKNPKF METVAEKALQ EYRKKHREE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

23 N-termini - 16 C-termini - 20 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P10909-2-unknown	MKTLLL...	2	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P10909-2-unknown	MKTLLL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194434
P10909-2-unknown	MKTLLL...	2	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194435
P10909-23-unknown	DQTVSD...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10909-23-unknown	DQTVSD...	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC443
P10909-23-unknown	DQTVSD...	23		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10909-23-unknown	DQTVSD...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113287
P10909-23-unknown	DQTVSD...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113288
P10909-25-unknown	TVSDNE...	25		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10909-25-unknown	TVSDNE...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180216
P10909-25-unknown	TVSDNE...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180217
P10909-34-unknown	MSNQGS...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71030
P10909-34-unknown	MSNQGS...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102612
P10909-34-unknown	MSNQGS...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102613
P10909-41-unknown	YVNKEI...	41		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10909-41-unknown	YVNKEI...	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180220
P10909-41-unknown	YVNKEI...	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180219
P10909-41-unknown	YVNKEI...	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180221
P10909-44-unknown	KEIQNA...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC446
P10909-44-unknown	KEIQNA...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139548
P10909-44-unknown	KEIQNA...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142211
P10909-44-unknown	KEIQNA...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195979
P10909-49-unknown	AVNGVK...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17290
P10909-49-unknown	AVNGVK...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18662
P10909-49-unknown	AVNGVK...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136591
P10909-49-unknown	AVNGVK...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139923
P10909-49-unknown	AVNGVK...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142458
P10909-59-unknown	LIEKTN...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20144
P10909-59-unknown	LIEKTN...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137285
P10909-59-unknown	LIEKTN...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140662
P10909-59-unknown	LIEKTN...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143018
P10909-68-unknown	KTLLSN...	68		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10909-68-unknown	KTLLSN...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180224
P10909-68-unknown	KTLLSN...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180223
P10909-68-unknown	KTLLSN...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180225
P10909-74-unknown	LEEAKK...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20148
P10909-74-unknown	LEEAKK...	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138449
P10909-74-unknown	LEEAKK...	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141594
P10909-74-unknown	LEEAKK...	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143744
P10909-176-unknown	MQDHFS...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71029
P10909-176-unknown	MQDHFS...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102561
P10909-176-unknown	MQDHFS...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102560
P10909-176-unknown	MQDHFS...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102562
P10909-183-unknown	ASSIID...	183		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10909-183-unknown	ASSIID...	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180229
P10909-183-unknown	ASSIID...	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180228
P10909-183-unknown	ASSIID...	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180227
P10909-183-unknown	ASSIID...	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180230
P10909-185-unknown	SIIDEL...	185		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10909-185-unknown	SIIDEL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180234
P10909-185-unknown	SIIDEL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180233
P10909-185-unknown	SIIDEL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180232
P10909-185-unknown	SIIDEL...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180235
P10909-215-unknown	RPHFFF...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC326
P10909-215-unknown	RPHFFF...	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138317
P10909-215-unknown	RPHFFF...	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145961
P10909-215-unknown	RPHFFF...	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147580
P10909-215-unknown	RPHFFF...	215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149039
P10909-227-unknown	RSLMPF...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC331
P10909-227-unknown	RSLMPF...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139333
P10909-227-unknown	RSLMPF...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146385
P10909-227-unknown	RSLMPF...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147991
P10909-227-unknown	RSLMPF...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149315
P10909-228-unknown	SLMPFS...	228	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10909-228-unknown	SLMPFS...	228	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116082
P10909-228-unknown	SLMPFS...	228	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116081
P10909-228-unknown	SLMPFS...	228	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116080
P10909-228-unknown	SLMPFS...	228	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116083
P10909-260-unknown	IHFHSP...	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23859
P10909-260-unknown	IHFHSP...	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20152
P10909-260-unknown	IHFHSP...	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141556
P10909-260-unknown	IHFHSP...	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147620
P10909-260-unknown	IHFHSP...	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149138
P10909-260-unknown	IHFHSP...	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150151
P10909-264-unknown	SPAFQH...	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18666
P10909-264-unknown	SPAFQH...	264	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141784
P10909-264-unknown	SPAFQH...	264	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147785
P10909-264-unknown	SPAFQH...	264	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149237
P10909-264-unknown	SPAFQH...	264	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150259
P10909-267-unknown	FQHPPT...	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19958
P10909-267-unknown	FQHPPT...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141972
P10909-267-unknown	FQHPPT...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147896
P10909-267-unknown	FQHPPT...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149299
P10909-267-unknown	FQHPPT...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150322
P10909-274-unknown	FIREGD...	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23864
P10909-274-unknown	FIREGD...	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20157
P10909-274-unknown	FIREGD...	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142341
P10909-274-unknown	FIREGD...	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148134
P10909-274-unknown	FIREGD...	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149464
P10909-274-unknown	FIREGD...	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150444
P10909-432-unknown	ETVAEK...	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17294
P10909-432-unknown	ETVAEK...	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18671
P10909-432-unknown	ETVAEK...	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148720
P10909-432-unknown	ETVAEK...	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151995
P10909-432-unknown	ETVAEK...	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152682
P10909-432-unknown	ETVAEK...	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153238
P10909-433-unknown	TVAEKA...	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC336
P10909-433-unknown	TVAEKA...	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17299
P10909-433-unknown	TVAEKA...	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18676
P10909-433-unknown	TVAEKA...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148740
P10909-433-unknown	TVAEKA...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152003
P10909-433-unknown	TVAEKA...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152696
P10909-433-unknown	TVAEKA...	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153247
P10909-442-unknown	YRKKHR...	442	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC341
P10909-442-unknown	YRKKHR...	442	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149040
P10909-442-unknown	YRKKHR...	442	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152148
P10909-442-unknown	YRKKHR...	442	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152820
P10909-442-unknown	YRKKHR...	442	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153343

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GQVLGD	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC443
...GQVLGD	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120916
...GQVLGD	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124138
...SKYVNK	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC446
...SKYVNK	43	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122640
...SKYVNK	43	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125399
...KEIQNA	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17290
...KEIQNA	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18662
...KEIQNA	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123028
...KEIQNA	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125652
...KQIKTL	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20144
...KQIKTL	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120217
...KQIKTL	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123797
...KQIKTL	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126229
...TLLSNL	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20148
...TLLSNL	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121490
...TLLSNL	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124772
...TLLSNL	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126987
...SLPHRR	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC326
...SLPHRR	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121354
...SLPHRR	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129260
...SLPHRR	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130932
...SLPHRR	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132423
...KSRIVR	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC331
...KSRIVR	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122408
...KSRIVR	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129690
...KSRIVR	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131354
...KSRIVR	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132700
...SRIVRS	227	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRIVRS	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92035
...SRIVRS	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92034
...SRIVRS	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92033
...SRIVRS	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92036
...QQAMDI	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23859
...QQAMDI	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20152
...QQAMDI	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124733
...QQAMDI	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130972
...QQAMDI	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132523
...QQAMDI	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133544
...DIHFHS	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18666
...DIHFHS	263	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124965
...DIHFHS	263	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131141
...DIHFHS	263	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132622
...DIHFHS	263	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133652
...FHSPAF	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19958
...FHSPAF	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125153
...FHSPAF	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131256
...FHSPAF	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132684
...FHSPAF	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133717
...HPPTEF	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23864
...HPPTEF	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC20157
...HPPTEF	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125532
...HPPTEF	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131501
...HPPTEF	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132849
...HPPTEF	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133840
...NPKFME	431	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17294
...NPKFME	431	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18671
...NPKFME	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132095
...NPKFME	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135403
...NPKFME	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136101
...NPKFME	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136663
...PKFMET	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC336
...PKFMET	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17299
...PKFMET	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18676
...PKFMET	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132116
...PKFMET	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135412
...PKFMET	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136116
...PKFMET	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136672
...KALQEY	441	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC341
...KALQEY	441	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132424
...KALQEY	441	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135558
...KALQEY	441	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136245
...KALQEY	441	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136767
...KHREE	449	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KHREE	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66647
...KHREE	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66648
...KHREE	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66649
...KHREE	449	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66646

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ATS5_HUMAN	22	VLGD.\|.DQTV	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS5_HUMAN	43	YVNK.\|.KEIQ	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MEP1A_HUMAN	48	IQNA.\|.AVNG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	48	IQNA.\|.AVNG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP12_HUMAN	58	IKTL.\|.LIEK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	73	LSNL.\|.LEEA	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	214	PHRR.\|.RPHF	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
ATS4_HUMAN	226	RIVR.\|.RSLM	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP3_HUMAN	259	AMDI.\|.IHFH	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	259	AMDI.\|.IHFH	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MEP1B_HUMAN	263	HFHS.\|.SPAF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP11_HUMAN	266	SPAF.\|.FQHP	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> CLUS_HUMAN @266
MMP3_HUMAN	273	PTEF.\|.FIRE	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MMP12_HUMAN	273	PTEF.\|.FIRE	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MEP1A_HUMAN	431	KFME.\|.ETVA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	431	KFME.\|.ETVA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
ATS4_HUMAN	432	FMET.\|.TVAE	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,
MEP1A_HUMAN	432	FMET.\|.TVAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	432	FMET.\|.TVAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
ATS4_HUMAN	441	LQEY.\|.YRKK	inferred from experiment	unknown	MEROPS	Duffin KL	Zhen EY et al.:Characterization of metalloprot... (M12.221)	18668564,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)