TopFIND 4.0

Q9UNA0: A disintegrin and metalloproteinase with thrombospondin motifs 5

General Information

Protein names
- A disintegrin and metalloproteinase with thrombospondin motifs 5
- ADAM-TS 5
- ADAM-TS5
- ADAMTS-5
- 3.4.24.-
- A disintegrin and metalloproteinase with thrombospondin motifs 11
- ADAM-TS 11
- ADAMTS-11
- ADMP-2
- Aggrecanase-2
Gene names ADAMTS5
Organism Homo sapiens
Protease Family M12.225
Protease ID M12.225
Chromosome location
UniProt ID Q9UNA0

4

N-termini

2

C-termini

1

Cleavages

74

Substrates

Sequence

        10         20         30         40         50         60 
MLLGWASLLL CAFRLPLAAV GPAATPAQDK AGQPPTAAAA AQPRRRQGEE VQERAEPPGH 
        70         80         90        100        110        120 
PHPLAQRRRS KGLVQNIDQL YSGGGKVGYL VYAGGRRFLL DLERDGSVGI AGFVPAGGGT 
       130        140        150        160        170        180 
SAPWRHRSHC FYRGTVDGSP RSLAVFDLCG GLDGFFAVKH ARYTLKPLLR GPWAEEEKGR 
       190        200        210        220        230        240 
VYGDGSARIL HVYTREGFSF EALPPRASCE TPASTPEAHE HAPAHSNPSG RAALASQLLD 
       250        260        270        280        290        300 
QSALSPAGGS GPQTWWRRRR RSISRARQVE LLLVADASMA RLYGRGLQHY LLTLASIANR 
       310        320        330        340        350        360 
LYSHASIENH IRLAVVKVVV LGDKDKSLEV SKNAATTLKN FCKWQHQHNQ LGDDHEEHYD 
       370        380        390        400        410        420 
AAILFTREDL CGHHSCDTLG MADVGTICSP ERSCAVIEDD GLHAAFTVAH EIGHLLGLSH 
       430        440        450        460        470        480 
DDSKFCEETF GSTEDKRLMS SILTSIDASK PWSKCTSATI TEFLDDGHGN CLLDLPRKQI 
       490        500        510        520        530        540 
LGPEELPGQT YDATQQCNLT FGPEYSVCPG MDVCARLWCA VVRQGQMVCL TKKLPAVEGT 
       550        560        570        580        590        600 
PCGKGRICLQ GKCVDKTKKK YYSTSSHGNW GSWGSWGQCS RSCGGGVQFA YRHCNNPAPR 
       610        620        630        640        650        660 
NNGRYCTGKR AIYRSCSLMP CPPNGKSFRH EQCEAKNGYQ SDAKGVKTFV EWVPKYAGVL 
       670        680        690        700        710        720 
PADVCKLTCR AKGTGYYVVF SPKVTDGTEC RLYSNSVCVR GKCVRTGCDG IIGSKLQYDK 
       730        740        750        760        770        780 
CGVCGGDNSS CTKIVGTFNK KSKGYTDVVR IPEGATHIKV RQFKAKDQTR FTAYLALKKK 
       790        800        810        820        830        840 
NGEYLINGKY MISTSETIID INGTVMNYSG WSHRDDFLHG MGYSATKEIL IVQILATDPT 
       850        860        870        880        890        900 
KPLDVRYSFF VPKKSTPKVN SVTSHGSNKV GSHTSQPQWV TGPWLACSRT CDTGWHTRTV 
       910        920        930    
QCQDGNRKLA KGCPLSQRPS AFKQCLLKKC 

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 74 Substrates

N-termini

C-termini

Cleavages

Substrates