P01023: Alpha-2-macroglobulin

General Information

Protein names	- Alpha-2-macroglobulin - Alpha-2-M - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Gene names	A2M
Organism	Homo sapiens
Protease Family
Protease ID	I39.001
Chromosome location
UniProt ID	P01023

14 N-termini

11 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL LSYLNETVTV
        70         80         90        100        110        120
SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV MFLTVQVKGP TQEFKKRTTV
       130        140        150        160        170        180
MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS MDENFHPLNE LIPLVYIQDP KGNRIAQWQS
       190        200        210        220        230        240
FQLEGGLKQF SFPLSSEPFQ GSYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT
       250        260        270        280        290        300
ILEEEMNVSV CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEKF SGQLNSHGCF
       310        320        330        340        350        360
YQQVKTKVFQ LKRKEYEMKL HTEAQIQEEG TVVELTGRQS SEITRTITKL SFVKVDSHFR
       370        380        390        400        410        420
QGIPFFGQVR LVDGKGVPIP NKVIFIRGNE ANYYSNATTD EHGLVQFSIN TTNVMGTSLT
       430        440        450        460        470        480
VRVNYKDRSP CYGYQWVSEE HEEAHHTAYL VFSPSKSFVH LEPMSHELPC GHTQTVQAHY
       490        500        510        520        530        540
ILNGGTLLGL KKLSFYYLIM AKGGIVRTGT HGLLVKQEDM KGHFSISIPV KSDIAPVARL
       550        560        570        580        590        600
LIYAVLPTGD VIGDSAKYDV ENCLANKVDL SFSPSQSLPA SHAHLRVTAA PQSVCALRAV
       610        620        630        640        650        660
DQSVLLMKPD AELSASSVYN LLPEKDLTGF PGPLNDQDNE DCINRHNVYI NGITYTPVSS
       670        680        690        700        710        720
TNEKDMYSFL EDMGLKAFTN SKIRKPKMCP QLQQYEMHGP EGLRVGFYES DVMGRGHARL
       730        740        750        760        770        780
VHVEEPHTET VRKYFPETWI WDLVVVNSAG VAEVGVTVPD TITEWKAGAF CLSEDAGLGI
       790        800        810        820        830        840
SSTASLRAFQ PFFVELTMPY SVIRGEAFTL KATVLNYLPK CIRVSVQLEA SPAFLAVPVE
       850        860        870        880        890        900
KEQAPHCICA NGRQTVSWAV TPKSLGNVNF TVSAEALESQ ELCGTEVPSV PEHGRKDTVI
       910        920        930        940        950        960
KPLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV LGDILGSAMQ
       970        980        990       1000       1010       1020
NTQNLLQMPY GCGEQNMVLF APNIYVLDYL NETQQLTPEI KSKAIGYLNT GYQRQLNYKH
      1030       1040       1050       1060       1070       1080
YDGSYSTFGE RYGRNQGNTW LTAFVLKTFA QARAYIFIDE AHITQALIWL SQRQKDNGCF
      1090       1100       1110       1120       1130       1140
RSSGSLLNNA IKGGVEDEVT LSAYITIALL EIPLTVTHPV VRNALFCLES AWKTAQEGDH
      1150       1160       1170       1180       1190       1200
GSHVYTKALL AYAFALAGNQ DKRKEVLKSL NEEAVKKDNS VHWERPQKPK APVGHFYEPQ
      1210       1220       1230       1240       1250       1260
APSAEVEMTS YVLLAYLTAQ PAPTSEDLTS ATNIVKWITK QQNAQGGFSS TQDTVVALHA
      1270       1280       1290       1300       1310       1320
LSKYGAATFT RTGKAAQVTI QSSGTFSSKF QVDNNNRLLL QQVSLPELPG EYSMKVTGEG
      1330       1340       1350       1360       1370       1380
CVYLQTSLKY NILPEKEEFP FALGVQTLPQ TCDEPKAHTS FQISLSVSYT GSRSASNMAI
      1390       1400       1410       1420       1430       1440
VDVKMVSGFI PLKPTVKMLE RSNHVSRTEV SSNHVLIYLD KVSNQTLSLF FTVLQDVPVR
      1450       1460       1470
DLKPAIVKVY DYYETDEFAI AEYNAPCSKD LGNA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 11 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01023-24-	SVSGKP...	24		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P01023-24-unknown	SVSGKP...	24	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01023-587-unknown	VTAAPQ...	587		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01023-703-unknown	LRVGFY...	703	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC25110
P01023-703-unknown	LRVGFY...	703	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC22088
P01023-703-unknown	LRVGFY...	703	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23660
P01023-703-unknown	LRVGFY...	703	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21717
P01023-705-unknown	VGFYES...	705		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01023-706-unknown	GFYESD...	706	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8341
P01023-706-unknown	GFYESD...	706		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01023-707-unknown	FYESDV...	707	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8342
P01023-707-unknown	FYESDV...	707		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01023-708-unknown	YESDVM...	708	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23661
P01023-708-unknown	YESDVM...	708	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8368
P01023-709-unknown	ESDVMG...	709	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8369
P01023-711-unknown	DVMGRG...	711	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC641
P01023-714-unknown	GRGHAR...	714	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC317
P01023-714-unknown	GRGHAR...	714	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC407
P01023-720-unknown	LVHVEE...	720	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27450
P01023-720-unknown	LVHVEE...	720	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC22089
P01023-720-unknown	LVHVEE...	720	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31737
P01023-720-unknown	LVHVEE...	720		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01023-835-unknown	LAVPVE...	835	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4643
P01023-884-unknown	GTEVPS...	884		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVYIQD	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000385710
...HGPEGL	702	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25110
...HGPEGL	702	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22088
...HGPEGL	702	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23660
...HGPEGL	702	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21717
...EGLRVG	705	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8341
...GLRVGF	706	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8342
...LRVGFY	707	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23661
...LRVGFY	707	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8368
...RVGFYE	708	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8369
...GFYESD	710	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC641
...ESDVMG	713	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC317
...ESDVMG	713	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC407
...RGHARL	719	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27450
...RGHARL	719	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22089
...RGHARL	719	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31737
...ASPAFL	834	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4643
...DLGNA	1474	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	702	PEGL.\|.LRVG	inferred from experiment	unknown	MEROPS	Stigbrand T	Arbelaez LF et al.:Interaction of matrix metallopr... (M10.003)	9344465,
MMP2_HUMAN	702	PEGL.\|.LRVG	inferred from experiment	unknown	MEROPS	Stigbrand T	Arbelaez LF et al.:Interaction of matrix metallopr... (M10.003)	9344465,
MMP3_HUMAN	702	PEGL.\|.LRVG	inferred from experiment	unknown	MEROPS	Nagase H	Enghild JJ et al.:Interaction of human rheumatoid... (M10.005)	2470748,
MMP1_HUMAN	702	PEGL.\|.LRVG	inferred from experiment	unknown	MEROPS		Merops MMP1_HUMAN -> A2MG_HUMAN @702
CELA1_HUMAN	705	LRVG.\|.GFYE	inferred from experiment	unknown	MEROPS	Magnusson S	Mortensen SB et al.:Primary and secondary cleavage ... (S01.153)	6172288,
CELA1_HUMAN	706	RVGF.\|.FYES	inferred from experiment	unknown	MEROPS	Magnusson S	Mortensen SB et al.:Primary and secondary cleavage ... (S01.153)	6172288,
MMP3_HUMAN	707	VGFY.\|.YESD	inferred from experiment	unknown	MEROPS	Salvesen G	Mast AE et al.:Kinetics and physiologic releva... (M10.001)	1651920,
CMA1_HUMAN	707	VGFY.\|.YESD	inferred from experiment	unknown	MEROPS	Schechter NM	Walter M et al.:Highly efficient inhibition of ... (S01.140)	10441378,
CMA1_HUMAN	708	GFYE.\|.ESDV	inferred from experiment	unknown	MEROPS	Schechter NM	Walter M et al.:Highly efficient inhibition of ... (S01.140)	10441378,
BMP1_HUMAN	710	YESD.\|.DVMG	inferred from experiment	unknown	MEROPS	Greenspan DS	Zhang Y et al.:Inhibition of bone morphogeneti... (M12.005)	17071617,
ATS4_HUMAN	713	DVMG.\|.GRGH	inferred from experiment	unknown	MEROPS	Malfait AM	Tortorella MD et al.:Alpha2-macroglobulin is a novel... (M12.221)	14715656,
ATS5_HUMAN	713	DVMG.\|.GRGH	inferred from experiment	unknown	MEROPS	Malfait AM	Tortorella MD et al.:Alpha2-macroglobulin is a novel... (M12.221)	14715656,
PLMN_HUMAN	719	HARL.\|.LVHV	inferred from experiment	unknown	MEROPS	Magnusson S	Mortensen SB et al.:Primary and secondary cleavage ... (S01.153)	6172288,
MMP2_HUMAN	719	HARL.\|.LVHV	inferred from experiment	unknown	MEROPS	Stigbrand T	Arbelaez LF et al.:Interaction of matrix metallopr... (M10.003)	9344465,
THRB_HUMAN	719	HARL.\|.LVHV	inferred from experiment	unknown	MEROPS	Magnusson S	Mortensen SB et al.:Primary and secondary cleavage ... (S01.153)	6172288,
CATE_HUMAN	834	PAFL.\|.LAVP	inferred from experiment	unknown	MEROPS	Yamamoto K	Yasuda Y et al.:A new selective substrate for c... (A01.010)	15843176,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)