P00747: Plasminogen

General Information

Protein names	- Plasminogen - 3.4.21.7 - Plasmin heavy chain A - Activation peptide - Angiostatin - Plasmin heavy chain A, short form - Plasmin light chain B
Gene names	PLG
Organism	Homo sapiens
Protease Family	S01.233
Protease ID	S01.233
Chromosome location
UniProt ID	P00747

21 N-termini

21 C-termini

24 Cleavages

182 Substrates

Sequence

        10         20         30         40         50         60
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA AKCEEDEEFT
        70         80         90        100        110        120
CRAFQYHSKE QQCVIMAENR KSSIIIRMRD VVLFEKKVYL SECKTGNGKN YRGTMSKTKN
       130        140        150        160        170        180
GITCQKWSST SPHRPRFSPA THPSEGLEEN YCRNPDNDPQ GPWCYTTDPE KRYDYCDILE
       190        200        210        220        230        240
CEEECMHCSG ENYDGKISKT MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDRE
       250        260        270        280        290        300
LRPWCFTTDP NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGNVAVT VSGHTCQHWS
       310        320        330        340        350        360
AQTPHTHNRT PENFPCKNLD ENYCRNPDGK RAPWCHTTNS QVRWEYCKIP SCDSSPVSTE
       370        380        390        400        410        420
QLAPTAPPEL TPVVQDCYHG DGQSYRGTSS TTTTGKKCQS WSSMTPHRHQ KTPENYPNAG
       430        440        450        460        470        480
LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN LKKCSGTEAS VVAPPPVVLL PDVETPSEED
       490        500        510        520        530        540
CMFGNGKGYR GKRATTVTGT PCQDWAAQEP HRHSIFTPET NPRAGLEKNY CRNPDGDVGG
       550        560        570        580        590        600
PWCYTTNPRK LYDYCDVPQC AAPSFDCGKP QVEPKKCPGR VVGGCVAHPH SWPWQVSLRT
       610        620        630        640        650        660
RFGMHFCGGT LISPEWVLTA AHCLEKSPRP SSYKVILGAH QEVNLEPHVQ EIEVSRLFLE
       670        680        690        700        710        720
PTRKDIALLK LSSPAVITDK VIPACLPSPN YVVADRTECF ITGWGETQGT FGAGLLKEAQ
       730        740        750        760        770        780
LPVIENKVCN RYEFLNGRVQ STELCAGHLA GGTDSCQGDS GGPLVCFEKD KYILQGVTSW
       790        800        810
GLGCARPNKP GVYVRVSRFV TWIEGVMRNN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

21 N-termini - 21 C-termini - 24 Cleavages - 182 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P00747-20-unknown	EPLDDY...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00747-79-unknown	NRKSSI...	79	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00747-79-unknown	NRKSSI...	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23652
P00747-94-unknown	FEKKVY...	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4319
P00747-95-unknown	EKKVYL...	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6961
P00747-97-unknown	KVYLSE...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16402
P00747-97-unknown	KVYLSE...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15907
P00747-97-unknown	KVYLSE...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27441
P00747-97-unknown	KVYLSE...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22085
P00747-98-unknown	VYLSEC...	98	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00747-359-unknown	TEQLAP...	359	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6962
P00747-373-unknown	VVQDCY...	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22086
P00747-459-unknown	ASVVAP...	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16116
P00747-461-unknown	VVAPPP...	461	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16510
P00747-466-unknown	PVVLLP...	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25107
P00747-467-unknown	VVLLPD...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23653
P00747-467-unknown	VVLLPD...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23954
P00747-469-unknown	LLPDVE...	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6963
P00747-470-unknown	LPDVET...	470	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7111
P00747-471-unknown	PDVETP...	471	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4320
P00747-488-unknown	GYRGKR...	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27442
P00747-550-unknown	KLYDYC...	550	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16403
P00747-550-unknown	KLYDYC...	550	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15908
P00747-564-unknown	SFDCGK...	564	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23654
P00747-581-unknown	VVGGCV...	581	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00747-581-unknown	VVGGCV...	581	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32072
P00747-581-unknown	VVGGCV...	581	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31865
P00747-719-unknown	AQLPVI...	719	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4321
P00747-787-unknown	PNKPGV...	787		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VIMAEN	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23652
...RDVVLF	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4319
...DVVLFE	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6961
...VLFEKK	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16402
...VLFEKK	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15907
...VLFEKK	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27441
...VLFEKK	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22085
...PHRPRF	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000355891
...EGLEEN	149	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389424
...SSPVST	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6962
...PELTPV	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22086
...CSGTEA	458	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16116
...GTEASV	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16510
...VVAPPP	465	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25107
...VAPPPV	466	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VAPPPV	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23653
...VAPPPV	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23954
...PPPVVL	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6963
...PPVVLL	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7111
...PVVLLP	470	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4320
...FGNGKG	487	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27442
...TTNPRK	549	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16403
...TTNPRK	549	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15908
...QCAAPS	563	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23654
...KCPGRV	580	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KCPGRV	580	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32072
...KCPGRV	580	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31865
...GLLKEA	718	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4321
...VMRNN	810	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP3_HUMAN	78	MAEN.\|.NRKS	inferred from experiment	unknown	MEROPS	Collen D	Lijnen HR et al.:Generation of an angiostatin-li... (M10.005)	9548733,
CATD_HUMAN	93	VVLF.\|.FEKK	inferred from experiment	unknown	MEROPS	Kuwano M	Morikawa W et al.:Angiostatin generation by cathe... (A01.009)	10986284,
CATL2_HUMAN	94	VLFE.\|.EKKV	inferred from experiment	unknown	MEROPS	Carmona AK	Puzer L et al.:Cathepsin V, but not cathepsins... (C01.009)	18163891,
KLK5_HUMAN	96	FEKK.\|.KVYL	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
KLK14_HUMAN	96	FEKK.\|.KVYL	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Expression and functional chara... (S01.029)	17110383,
PLMN_HUMAN	96	FEKK.\|.KVYL	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> PLMN_HUMAN @96
MMP2_HUMAN	96	FEKK.\|.KVYL	inferred from experiment	unknown	MEROPS	Shapiro SD	Cornelius LA et al.:Matrix metalloproteinases gener... (M10.003)	9862716,
CATL2_HUMAN	358	PVST.\|.TEQL	inferred from experiment	unknown	MEROPS	Carmona AK	Puzer L et al.:Cathepsin V, but not cathepsins... (C01.009)	18163891,
MMP2_HUMAN	372	LTPV.\|.VVQD	inferred from experiment	unknown	MEROPS	Shapiro SD	Cornelius LA et al.:Matrix metalloproteinases gener... (M10.003)	9862716,
KLK3_HUMAN	458	GTEA.\|.ASVV	inferred from experiment	unknown	MEROPS	Kontermann RE	Heidtmann HH et al.:Generation of angiostatin-like ... (S01.162)	10604721,
KLK6_HUMAN	460	EASV.\|.VVAP	inferred from experiment	unknown	MEROPS	Sotiropoulou G	Bayes A et al.:Human kallikrein 6 activity is ... (S01.236)	15255184,
MMP9_HUMAN	465	APPP.\|.PVVL	inferred from experiment	unknown	MEROPS	Sang QA	Patterson BC et al.:Angiostatin-converting enzyme a... (M10.008)	9360944,
MMP3_HUMAN	466	PPPV.\|.VVLL	inferred from experiment	unknown	MEROPS	Collen D	Lijnen HR et al.:Generation of an angiostatin-li... (M10.005)	9548733,
MMP7_HUMAN	466	PPPV.\|.VVLL	inferred from experiment	unknown	MEROPS	Sang QA	Patterson BC et al.:Angiostatin-converting enzyme a... (M10.008)	9360944,
CATL2_HUMAN	468	PVVL.\|.LLPD	inferred from experiment	unknown	MEROPS	Carmona AK	Puzer L et al.:Cathepsin V, but not cathepsins... (C01.009)	18163891,
CATS_HUMAN	469	VVLL.\|.LPDV	inferred from experiment	unknown	MEROPS	Carmona AK	Coppini LP et al.:Plasminogen hydrolysis by cathe... (C01.034)	20302511,
CATD_HUMAN	470	VLLP.\|.PDVE	inferred from experiment	unknown	MEROPS	Kuwano M	Morikawa W et al.:Angiostatin generation by cathe... (A01.009)	10986284,
PLMN_HUMAN	487	NGKG.\|.GYRG	inferred from experiment	unknown	MEROPS	Waisman DM	Kwon M et al.:Annexin A2-S100A10 heterotetram... (S01.233)	15849182,
KLK5_HUMAN	549	NPRK.\|.KLYD	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
KLK14_HUMAN	549	NPRK.\|.KLYD	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Expression and functional chara... (S01.029)	17110383,
MMP3_HUMAN	563	AAPS.\|.SFDC	inferred from experiment	unknown	MEROPS	Collen D	Lijnen HR et al.:Generation of an angiostatin-li... (M10.005)	9548733,
UROK_HUMAN	580	PGRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Shah RJ	Robbins KC et al.:The peptide chains of human pla... (S01.231)	4226004,
TPA_HUMAN	580	PGRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Rojas G	Angles-Cano E et al.:Apolipoprotein(a): structure-fu... (S01.232)	11928826,
CATD_HUMAN	718	LKEA.\|.AQLP	inferred from experiment	unknown	MEROPS	Kuwano M	Morikawa W et al.:Angiostatin generation by cathe... (A01.009)	10986284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CCL14_HUMAN	27	SSRG.\|.GPYH	inferred from experiment	unknown	MEROPS	Parmentier M	Vakili J et al.:Urokinase plasminogen activator... (S01.233)	11544332,
HPLN1_HUMAN	28	HDRA.\|.AIHI	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> HPLN1_HUMAN @28
PAR1_HUMAN	32	ESKA.\|.ATNA	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PAR2_HUMAN	34	SSKG.\|.GRSL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
FIBA-Isoform2_HUMAN	35	GVRG.\|.GPRV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27454
FIBA_HUMAN	35	GVRG.\|.GPRV	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PAR2_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CFAI_HUMAN	36	LAKK.\|.KYTH	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
CFAI_HUMAN	37	AKKY.\|.YTHL	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
FIBA-Isoform2_HUMAN	38	GPRV.\|.VVER	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27456
FIBA_HUMAN	38	GPRV.\|.VVER	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PAR1_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PAR4_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Steinberg SF	Steinberg SF et al.:The cardiovascular actions of p... (S01.133)	15371558,
FIBB_HUMAN	51	LDKK.\|.KREE	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
FA8_HUMAN	55	VPKS.\|.SFPF	inferred from experiment	unknown	MEROPS	Yoshioka A	Nogami K et al.:Mechanisms of plasmin-catalyzed... (S01.233)	17189254,
MMP13_HUMAN	57	ILKE.\|.ENAA	inferred from experiment	unknown	MEROPS	Murphy G	Knauper V et al.:Cellular mechanisms for human p... (M10.014)	8663255,
ELAF_HUMAN	60	KVKA.\|.AQEP	inferred from experiment	unknown	MEROPS	Moreau T	Guyot N et al.:Proteolytic susceptibility of t... (C01.036)	15899702,
MEP1A_HUMAN	65	KSRN.\|.NGLR	inferred from experiment	unknown	MEROPS	Sterchi EE	Rosmann S et al.:Activation of human meprin-alph... (S01.233)	12189145,
PAR1_HUMAN	70	EYRL.\|.LVSI	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
FIBB_HUMAN	72	GYRA.\|.ARPA	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PAR1_HUMAN	76	INKS.\|.SSPL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
FIBB_HUMAN	77	PAKA.\|.AAAT	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
CFAI_HUMAN	79	TNRR.\|.RSFP	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PAR1_HUMAN	82	LQKQ.\|.QLPA	inferred from experiment	unknown	MEROPS	Steinberg SF	Steinberg SF et al.:The cardiovascular actions of p... (S01.133)	15371558,
FIBB_HUMAN	83	TQKK.\|.KVER	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
FIBG-Isoform2_HUMAN	88	LIKA.\|.AIQL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27465
VEGFD_HUMAN	88	STRF.\|.FAAT	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Plasmin activates the lymphangi... (S01.233)	12963694,
FIBG_HUMAN	88	LIKA.\|.AIQL	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
CFAI_HUMAN	89	QQKS.\|.SLEC	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
OSTCN_HUMAN	94	AYRR.\|.RFYG	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
MMP13_HUMAN	95	KPRC.\|.CGVP	inferred from experiment	unknown	MEROPS	Murphy G	Knauper V et al.:Cellular mechanisms for human p... (M10.014)	8663255,
PLMN_HUMAN	96	FEKK.\|.KVYL	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> PLMN_HUMAN @96
MMP1_HUMAN	99	VAQF.\|.FVLT	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> MMP1_HUMAN @99
VEGFD_HUMAN	100	TLKV.\|.VIDE	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Plasmin activates the lymphangi... (S01.233)	12963694,
MMP13_HUMAN	103	VGEY.\|.YNVF	inferred from experiment	unknown	MEROPS	Murphy G	Knauper V et al.:Cellular mechanisms for human p... (M10.014)	8663255,
IGHG1_HUMAN	105	CDKT.\|.THTC	inferred from experiment	unknown	MEROPS	Jordan RE	Ryan MH et al.:Proteolysis of purified IgGs by... (S01.133)	18157932,
UPAR_HUMAN	105	SGRA.\|.AVTY	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
UPAR-Isoform3_HUMAN	105	SGRA.\|.AVTY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27594
UPAR-Isoform2_HUMAN	105	SGRA.\|.AVTY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27594
MMP14_HUMAN	108	NVRR.\|.RKRY	inferred from experiment	unknown	MEROPS	Kido H	Okumura Y et al.:Proteolytic activation of the p... (S01.233)	9037191,
UPAR_HUMAN	111	YSRS.\|.SRYL	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
FIBG-Isoform2_HUMAN	111	TLKS.\|.SRKM	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27467
FIBG_HUMAN	111	TLKS.\|.SRKM	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
UPAR-Isoform3_HUMAN	111	YSRS.\|.SRYL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27597
UPAR-Isoform2_HUMAN	111	YSRS.\|.SRYL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27597
MMP14_HUMAN	111	RKRY.\|.YAIQ	inferred from experiment	unknown	MEROPS	Kido H	Okumura Y et al.:Proteolytic activation of the p... (S01.233)	9037191,
SDC4-Isoform2_HUMAN	114	IPKR.\|.RISP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27577
SDC4_HUMAN	114	IPKR.\|.RISP	inferred from experiment	unknown	MEROPS	Buddecke E	Schmidt A et al.:Plasmin- and thrombin-accelerat... (S01.233)	16087677,
IBP3-Isoform2_HUMAN	122	VSRL.\|.LRAY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27551
IBP3_HUMAN	122	VSRL.\|.LRAY	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
FIBA-Isoform2_HUMAN	123	NNRD.\|.DNTY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27458
FIBA_HUMAN	123	NNRD.\|.DNTY	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
IBP3_HUMAN	124	RLRA.\|.AYLL	inferred from experiment	unknown	MEROPS	Cohen P	Gibson TL et al.:Inflammation-related neutrophil... (S01.133)	10512690,
IBP3-Isoform2_HUMAN	124	RLRA.\|.AYLL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27553
BDNF_HUMAN	125	SMRV.\|.VRRH	inferred from experiment	unknown	MEROPS	Ellis V	Gray K et al.:Activation of pro-BDNF by the p... (S01.233)	18291105,
SDC4-Isoform2_HUMAN	128	SNKV.\|.VSMS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27579
SDC4_HUMAN	128	SNKV.\|.VSMS	inferred from experiment	unknown	MEROPS	Buddecke E	Schmidt A et al.:Plasmin- and thrombin-accelerat... (S01.233)	16087677,
BDNF-Isoform2_HUMAN	133	SMRV.\|.VRRH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27567
UROK-Isoform2_HUMAN	138	DGKK.\|.KPSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27443
BDNF-Isoform3_HUMAN	140	SMRV.\|.VRRH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27567
OSTP-Isoform3_HUMAN	141	GLRS.\|.SKSK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27520
TPA-Isoform4_HUMAN	143	QFRI.\|.IKGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27447
OSTP-Isoform3_HUMAN	143	RSKS.\|.SKKF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27525
OSTP-Isoform4_HUMAN	146	GLRS.\|.SKSK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27520
OSTP-Isoform4_HUMAN	148	RSKS.\|.SKKF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27525
OSTP-Isoform3_HUMAN	151	RPDI.\|.IQYP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27530
OSTP-Isoform5_HUMAN	154	GLRS.\|.SKSK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27520
OSTP-Isoform2_HUMAN	154	GLRS.\|.SKSK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27520
BDNF-Isoform5_HUMAN	154	SMRV.\|.VRRH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27567
UROK_HUMAN	155	DGKK.\|.KPSS	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> UROK_HUMAN @155
OSTP-Isoform5_HUMAN	156	RSKS.\|.SKKF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27525
OSTP-Isoform2_HUMAN	156	RSKS.\|.SKKF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27525
OSTP-Isoform4_HUMAN	156	RPDI.\|.IQYP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27530
KLK11-Isoform1_HUMAN	156	QLRL.\|.LPHT	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27606
RARR2_HUMAN	158	FSKA.\|.ALPR	inferred from experiment	unknown	MEROPS	Butcher EC	Zabel BA et al.:Chemerin activation by serine p... (S01.131)	16096270,
UROK-Isoform2_HUMAN	161	RFKI.\|.IIGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27445
FIBB_HUMAN	163	QVKD.\|.DNEN	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
OSTP-Isoform5_HUMAN	164	RPDI.\|.IQYP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27530
OSTP-Isoform2_HUMAN	164	RPDI.\|.IQYP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27530
OSTP_HUMAN	168	GLRS.\|.SKSK	inferred from experiment	unknown	MEROPS	Sorensen ES	Christensen B et al.:Osteopontin is cleaved at multi... (A01.009)	20071328,
IBP3_HUMAN	169	PLHS.\|.SKII	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
OSTP_HUMAN	170	RSKS.\|.SKKF	inferred from experiment	unknown	MEROPS	Sorensen ES	Christensen B et al.:Osteopontin is cleaved at multi... (A01.009)	20071328,
CFAI_HUMAN	170	RFKL.\|.LSDL	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
IBP3-Isoform2_HUMAN	175	PLHS.\|.SKII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27555
OSTP-Isoform3_HUMAN	176	AYKA.\|.AIPV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27535
OSTP_HUMAN	178	RPDI.\|.IQYP	inferred from experiment	unknown	MEROPS	Sorensen ES	Christensen B et al.:Osteopontin is cleaved at multi... (A01.009)	20071328,
UROK_HUMAN	178	RFKI.\|.IIGG	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> UROK_HUMAN @178
OSTP-Isoform4_HUMAN	181	AYKA.\|.AIPV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27535
KLK11-Isoform4_HUMAN	181	QLRL.\|.LPHT	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27606
IBP3_HUMAN	185	SQRY.\|.YKVD	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
IBP3_HUMAN	187	RYKV.\|.VDYE	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
KLK11_HUMAN	188	QLRL.\|.LPHT	inferred from experiment	unknown	MEROPS	Diamandis EP	Luo LY et al.:Purification and characterizati... (S01.161)	16467084,
OSTP-Isoform5_HUMAN	189	AYKA.\|.AIPV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27535
OSTP-Isoform2_HUMAN	189	AYKA.\|.AIPV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27535
IBP3-Isoform2_HUMAN	191	SQRY.\|.YKVD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27557
IBP3-Isoform2_HUMAN	193	RYKV.\|.VDYE	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27559
OSTP_HUMAN	203	AYKA.\|.AIPV	inferred from experiment	unknown	MEROPS	Sorensen ES	Christensen B et al.:Osteopontin is cleaved at multi... (A01.009)	20071328,
VEGFD_HUMAN	205	IRRS.\|.SIQI	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Plasmin activates the lymphangi... (S01.233)	12963694,
BDNF-Isoform4_HUMAN	207	SMRV.\|.VRRH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27567
KLK11-Isoform3_HUMAN	213	QLRL.\|.LPHT	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27606
IBP3_HUMAN	225	HLKF.\|.FLNV	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
IBP3-Isoform2_HUMAN	231	HLKF.\|.FLNV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27561
CBPN_HUMAN	238	GVRR.\|.RTAS	inferred from experiment	unknown	MEROPS	Skidgel RA	Quagraine MO et al.:Plasmin alters the activity and... (S01.233)	15617514,
IBP3_HUMAN	247	FYKK.\|.KKQC	inferred from experiment	unknown	MEROPS	Binoux M	Lalou C et al.:Proteolytic fragments of insuli... (S01.233)	9337997,
IBP3-Isoform2_HUMAN	253	FYKK.\|.KKQC	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27563
CFAI_HUMAN	257	CCKA.\|.ACQG	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
TPA-Isoform3_HUMAN	264	QFRI.\|.IKGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27447
TPA_HUMAN	310	QFRI.\|.IKGG	inferred from experiment	unknown	MEROPS	Vehar GA	Tate KM et al.:Functional role of proteolytic ... (S01.233)	3103680,
NMDE1_HUMAN	317	EAKA.\|.ASCY	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
NMDE1-Isoform2_HUMAN	317	EAKA.\|.ASCY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27600
CFAI_HUMAN	319	RIKS.\|.SLLP	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
FA10_HUMAN	335	TFRM.\|.MNVA	inferred from experiment	unknown	MEROPS	Kessler GE	Pryzdial EL et al.:Plasmin converts factor X from ... (S01.233)	10085082,
APOH_HUMAN	336	FWKT.\|.TDAS	inferred from experiment	unknown	MEROPS	Kato H	Ohkura N et al.:Plasmin can reduce the function... (S01.216)	9596664,
A2AP-Isoform2_HUMAN	339	MSRM.\|.MSLS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27518
CFAI_HUMAN	339	RKRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
CFAI_HUMAN	344	GGKR.\|.RAQL	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
FA8_HUMAN	355	QLRM.\|.MKNN	inferred from experiment	unknown	MEROPS	Yoshioka A	Nogami K et al.:Mechanisms of plasmin-catalyzed... (S01.233)	17189254,
CMGA_HUMAN	368	DNRD.\|.DSSM	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
FA10_HUMAN	370	HEKG.\|.GRQS	inferred from experiment	unknown	MEROPS	Kessler GE	Pryzdial EL et al.:Plasmin converts factor X from ... (S01.233)	10085082,
CMGA_HUMAN	373	SMKL.\|.LSFR	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
CMGA_HUMAN	377	SFRA.\|.ARAY	inferred from experiment	unknown	MEROPS	Parmer RJ	Jiang Q et al.:Proteolytic cleavage of chromog... (S01.233)	11342539,
CMGA_HUMAN	379	RARA.\|.AYGF	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
VTNC_HUMAN	380	GYRS.\|.SQRG	inferred from experiment	unknown	MEROPS	Shaltiel S	Chain D et al.:Plasmin cleavage of vitronectin... (S01.233)	1713175,
FIBG-Isoform2_HUMAN	382	YSKA.\|.ASTP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27469
FIBG_HUMAN	382	YSKA.\|.ASTP	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
CMGA_HUMAN	384	GFRG.\|.GPGP	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
FA8_HUMAN	391	QIRS.\|.SVAK	inferred from experiment	unknown	MEROPS	Yoshioka A	Nogami K et al.:Mechanisms of plasmin-catalyzed... (S01.233)	17189254,
CMGA_HUMAN	391	QLRR.\|.RGWR	inferred from experiment	unknown	MEROPS	Parmer RJ	Jiang Q et al.:Proteolytic cleavage of chromog... (S01.233)	11342539,
PGCA_HUMAN	394	EARG.\|.GSVI	inferred from experiment	unknown	MEROPS	Okada Y	Fosang AJ et al.:Membrane-type 1 MMP (MMP-14) cl... (M10.013)	9688535,
PGCA-Isoform3_HUMAN	394	EARG.\|.GSVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27548
PGCA-Isoform2_HUMAN	394	EARG.\|.GSVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27548
FIBG-Isoform2_HUMAN	399	TWKT.\|.TRWY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27471
FIBG_HUMAN	399	TWKT.\|.TRWY	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
A2AP_HUMAN	403	MSRM.\|.MSLS	inferred from experiment	unknown	MEROPS	Collen D	Holmes WE et al.:Primary structure of human alph... (S01.233)	2433286,
CFAI_HUMAN	405	DLKR.\|.RIVI	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
MIS_HUMAN	451	AQRS.\|.SAGA	inferred from experiment	unknown	MEROPS	MacLaughlin DT	Maggard MA et al.:Reduction of epidermal growth f... (S01.233)	8596488,
CPN2_HUMAN	478	AARS.\|.SQCT	inferred from experiment	unknown	MEROPS	Skidgel RA	Quagraine MO et al.:Plasmin alters the activity and... (S01.233)	15617514,
PLMN_HUMAN	487	NGKG.\|.GYRG	inferred from experiment	unknown	MEROPS	Waisman DM	Kwon M et al.:Annexin A2-S100A10 heterotetram... (S01.233)	15849182,
CERU_HUMAN	500	QSRS.\|.SVPP	inferred from experiment	unknown	MEROPS	Putnam FW	Kingston IB et al.:Chemical evidence that proteoly... (S01.233)	146197,
A4-Isoform10_HUMAN	545	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform10_HUMAN	556	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform10_HUMAN	568	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform3_HUMAN	583	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform3_HUMAN	594	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform4_HUMAN	601	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform5_HUMAN	602	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform3_HUMAN	606	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform4_HUMAN	612	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform5_HUMAN	613	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform6_HUMAN	620	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform4_HUMAN	624	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform5_HUMAN	625	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform6_HUMAN	631	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform7_HUMAN	639	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform6_HUMAN	643	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform7_HUMAN	650	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform11_HUMAN	652	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform8_HUMAN	657	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform9_HUMAN	658	EFRH.\|.HDSG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27478
A4-Isoform7_HUMAN	662	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform11_HUMAN	663	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform8_HUMAN	668	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform9_HUMAN	669	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27488
A4-Isoform11_HUMAN	675	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4_HUMAN	676	EFRH.\|.HDSG	inferred from experiment	unknown	MEROPS	Estus S	Tucker HM et al.:The plasmin system is induced b... (S01.233)	10818128,
A4-Isoform8_HUMAN	680	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4-Isoform9_HUMAN	681	SNKG.\|.GAII	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27498
A4_HUMAN	687	HQKL.\|.LVFF	inferred from experiment	unknown	MEROPS	Estus S	Tucker HM et al.:The plasmin system is induced b... (S01.233)	10818128,
A4_HUMAN	699	SNKG.\|.GAII	inferred from experiment	unknown	MEROPS	Estus S	Tucker HM et al.:The plasmin system is induced b... (S01.233)	10818128,
A2MG_HUMAN	719	HARL.\|.LVHV	inferred from experiment	unknown	MEROPS	Magnusson S	Mortensen SB et al.:Primary and secondary cleavage ... (S01.153)	6172288,
CO3_HUMAN	748	LARS.\|.SNLD	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> CO3_HUMAN @748
CO5_HUMAN	751	LGRL.\|.LHMK	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> CO5_HUMAN @751
FA8_HUMAN	759	EPRS.\|.SFSQ	inferred from experiment	unknown	MEROPS	Yoshioka A	Nogami K et al.:Mechanisms of plasmin-catalyzed... (S01.233)	17189254,
L1CAM-Isoform3_HUMAN	855	QRKH.\|.HSKR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27581
L1CAM-Isoform3_HUMAN	858	HSKR.\|.RHIH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27584
L1CAM-Isoform2_HUMAN	860	QRKH.\|.HSKR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27581
L1CAM_HUMAN	860	QRKH.\|.HSKR	inferred from experiment	unknown	MEROPS	Montgomery AM	Nayeem N et al.:A potential role for the plasmi... (S01.233)	10574721,
L1CAM-Isoform2_HUMAN	863	HSKR.\|.RHIH	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27584
L1CAM_HUMAN	863	HSKR.\|.RHIH	inferred from experiment	unknown	MEROPS	Montgomery AM	Nayeem N et al.:A potential role for the plasmi... (S01.233)	10574721,
CERU_HUMAN	906	YLKV.\|.VFNP	inferred from experiment	unknown	MEROPS	Putnam FW	Kingston IB et al.:Chemical evidence that proteoly... (S01.233)	146197,
FA8_HUMAN	1708	SPRS.\|.SFQK	inferred from experiment	unknown	MEROPS	Yoshioka A	Nogami K et al.:Mechanisms of plasmin-catalyzed... (S01.233)	17189254,
FA8_HUMAN	1740	RNRA.\|.AQSG	inferred from experiment	unknown	MEROPS	Yoshioka A	Nogami K et al.:Mechanisms of plasmin-catalyzed... (S01.233)	17189254,