TopFIND 4.0

P19957: Elafin

General Information

Protein names	- Elafin - Elastase-specific inhibitor - ESI - Peptidase inhibitor 3 - PI-3 - Protease inhibitor WAP3 - Skin-derived antileukoproteinase - SKALP - WAP four-disulfide core domain protein 14
Gene names	PI3
Organism	Homo sapiens
Protease Family
Protease ID	I17.002
Chromosome location
UniProt ID	P19957

9

N-termini

9

C-termini

14

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MRASSFLIVV VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ VSVKGQDKVK
70 80 90 100 110
AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG IKKCCEGSCG MACFVPQ

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P19957-23-unknown	AVTGVP...	23			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P19957-57-unknown	DKVKAQ...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17424
P19957-57-unknown	DKVKAQ...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18837
P19957-61-unknown	AQEPVK...	61		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19957-61-unknown	AQEPVK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5652
P19957-61-unknown	AQEPVK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5021
P19957-61-unknown	AQEPVK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27565
P19957-61-unknown	AQEPVK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31971
P19957-62-unknown	QEPVKG...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17425
P19957-62-unknown	QEPVKG...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18838
P19957-63-unknown	EPVKGP...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17426
P19957-63-unknown	EPVKGP...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18839
P19957-66-unknown	KGPVST...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9382
P19957-70-unknown	STKPGS...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9383
P19957-71-unknown	TKPGSC...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17427
P19957-85-unknown	MLNPPN...	85		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9384

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SVKGQD	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17424
	...SVKGQD	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18837
	...QDKVKA	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5652
	...QDKVKA	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5021
	...QDKVKA	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27565
	...QDKVKA	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31971
	...DKVKAQ	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17425
	...DKVKAQ	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18838
	...KVKAQE	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17426
	...KVKAQE	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18839
	...AQEPVK	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9382
	...VKGPVS	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9383
	...KGPVST	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17427
	...LIRCAM	84	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9384
	...CFVPQ	117	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	56	KGQD.\|.DKVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	56	KGQD.\|.DKVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	60	KVKA.\|.AQEP	inferred from experiment	unknown	MEROPS	Moreau T	Guyot N et al.:Proteolytic susceptibility of t... (C01.036)	15899702,
CATK_HUMAN	60	KVKA.\|.AQEP	inferred from experiment	unknown	MEROPS	Moreau T	Guyot N et al.:Proteolytic susceptibility of t... (C01.036)	15899702,
PLMN_HUMAN	60	KVKA.\|.AQEP	inferred from experiment	unknown	MEROPS	Moreau T	Guyot N et al.:Proteolytic susceptibility of t... (C01.036)	15899702,
TRYB1_HUMAN	60	KVKA.\|.AQEP	inferred from experiment	unknown	MEROPS	Moreau T	Guyot N et al.:Proteolytic susceptibility of t... (C01.036)	15899702,
MEP1A_HUMAN	61	VKAQ.\|.QEPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	61	VKAQ.\|.QEPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	62	KAQE.\|.EPVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	62	KAQE.\|.EPVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
ELNE_HUMAN	65	EPVK.\|.KGPV	inferred from experiment	unknown	MEROPS	McElvaney NG	Guyot N et al.:Elafin, an elastase-specific in... (S01.131)	18799464,
ELNE_HUMAN	69	GPVS.\|.STKP	inferred from experiment	unknown	MEROPS	McElvaney NG	Guyot N et al.:Elafin, an elastase-specific in... (S01.131)	18799464,
MEP1A_HUMAN	70	PVST.\|.TKPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
ELNE_HUMAN	84	RCAM.\|.MLNP	inferred from experiment	unknown	MEROPS	McElvaney NG	Guyot N et al.:Elafin, an elastase-specific in... (S01.131)	18799464,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)