P01024: Complement C3

General Information

Protein names	- Complement C3 - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 - Complement C3 beta chain - C3-beta-c - C3bc - Complement C3 alpha chain - C3a anaphylatoxin - Acylation stimulating protein - ASP - C3adesArg - Complement C3b alpha' chain - Complement C3c alpha' chain fragment 1 - Complement C3dg fragment - Complement C3g fragment - Complement C3d fragment - Complement C3f fragment - Complement C3c alpha' chain fragment 2
Gene names	C3
Organism	Homo sapiens
Protease Family
Protease ID	I39.950
Chromosome location
UniProt ID	P01024

36 N-termini

17 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGPTSGPSLL LLLLTHLPLA LGSPMYSIIT PNILRLESEE TMVLEAHDAQ GDVPVTVTVH
        70         80         90        100        110        120
DFPGKKLVLS SEKTVLTPAT NHMGNVTFTI PANREFKSEK GRNKFVTVQA TFGTQVVEKV
       130        140        150        160        170        180
VLVSLQSGYL FIQTDKTIYT PGSTVLYRIF TVNHKLLPVG RTVMVNIENP EGIPVKQDSL
       190        200        210        220        230        240
SSQNQLGVLP LSWDIPELVN MGQWKIRAYY ENSPQQVFST EFEVKEYVLP SFEVIVEPTE
       250        260        270        280        290        300
KFYYIYNEKG LEVTITARFL YGKKVEGTAF VIFGIQDGEQ RISLPESLKR IPIEDGSGEV
       310        320        330        340        350        360
VLSRKVLLDG VQNPRAEDLV GKSLYVSATV ILHSGSDMVQ AERSGIPIVT SPYQIHFTKT
       370        380        390        400        410        420
PKYFKPGMPF DLMVFVTNPD GSPAYRVPVA VQGEDTVQSL TQGDGVAKLS INTHPSQKPL
       430        440        450        460        470        480
SITVRTKKQE LSEAEQATRT MQALPYSTVG NSNNYLHLSV LRTELRPGET LNVNFLLRMD
       490        500        510        520        530        540
RAHEAKIRYY TYLIMNKGRL LKAGRQVREP GQDLVVLPLS ITTDFIPSFR LVAYYTLIGA
       550        560        570        580        590        600
SGQREVVADS VWVDVKDSCV GSLVVKSGQS EDRQPVPGQQ MTLKIEGDHG ARVVLVAVDK
       610        620        630        640        650        660
GVFVLNKKNK LTQSKIWDVV EKADIGCTPG SGKDYAGVFS DAGLTFTSSS GQQTAQRAEL
       670        680        690        700        710        720
QCPQPAARRR RSVQLTEKRM DKVGKYPKEL RKCCEDGMRE NPMRFSCQRR TRFISLGEAC
       730        740        750        760        770        780
KKVFLDCCNY ITELRRQHAR ASHLGLARSN LDEDIIAEEN IVSRSEFPES WLWNVEDLKE
       790        800        810        820        830        840
PPKNGISTKL MNIFLKDSIT TWEILAVSMS DKKGICVADP FEVTVMQDFF IDLRLPYSVV
       850        860        870        880        890        900
RNEQVEIRAV LYNYRQNQEL KVRVELLHNP AFCSLATTKR RHQQTVTIPP KSSLSVPYVI
       910        920        930        940        950        960
VPLKTGLQEV EVKAAVYHHF ISDGVRKSLK VVPEGIRMNK TVAVRTLDPE RLGREGVQKE
       970        980        990       1000       1010       1020
DIPPADLSDQ VPDTESETRI LLQGTPVAQM TEDAVDAERL KHLIVTPSGC GEQNMIGMTP
      1030       1040       1050       1060       1070       1080
TVIAVHYLDE TEQWEKFGLE KRQGALELIK KGYTQQLAFR QPSSAFAAFV KRAPSTWLTA
      1090       1100       1110       1120       1130       1140
YVVKVFSLAV NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DAPVIHQEMI GGLRNNNEKD
      1150       1160       1170       1180       1190       1200
MALTAFVLIS LQEAKDICEE QVNSLPGSIT KAGDFLEANY MNLQRSYTVA IAGYALAQMG
      1210       1220       1230       1240       1250       1260
RLKGPLLNKF LTTAKDKNRW EDPGKQLYNV EATSYALLAL LQLKDFDFVP PVVRWLNEQR
      1270       1280       1290       1300       1310       1320
YYGGGYGSTQ ATFMVFQALA QYQKDAPDHQ ELNLDVSLQL PSRSSKITHR IHWESASLLR
      1330       1340       1350       1360       1370       1380
SEETKENEGF TVTAEGKGQG TLSVVTMYHA KAKDQLTCNK FDLKVTIKPA PETEKRPQDA
      1390       1400       1410       1420       1430       1440
KNTMILEICT RYRGDQDATM SILDISMMTG FAPDTDDLKQ LANGVDRYIS KYELDKAFSD
      1450       1460       1470       1480       1490       1500
RNTLIIYLDK VSHSEDDCLA FKVHQYFNVE LIQPGAVKVY AYYNLEESCT RFYHPEKEDG
      1510       1520       1530       1540       1550       1560
KLNKLCRDEL CRCAEENCFI QKSDDKVTLE ERLDKACEPG VDYVYKTRLV KVQLSNDFDE
      1570       1580       1590       1600       1610       1620
YIMAIEQTIK SGSDEVQVGQ QRTFISPIKC REALKLEEKK HYLMWGLSSD FWGEKPNLSY
      1630       1640       1650       1660
IIGKDTWVEH WPEEDECQDE ENQKQCQDLG AFTESMVVFG CPN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

36 N-termini - 17 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01024-23-unknown	SPMYSI...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01024-23-unknown	SPMYSI...	23		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-25-unknown	MYSIIT...	25		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-42-unknown	MVLEAH...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000472044
P01024-672-unknown	SVQLTE...	672	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01024-672-unknown	SVQLTE...	672		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P01024-672-unknown	SVQLTE...	672		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-672-	SVQLTE...	672		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P01024-692-unknown	KCCEDG...	692		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-693-unknown	CCEDGM...	693		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-713-unknown	FISLGE...	713		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-741-unknown	ASHLGL...	741		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-748-unknown	RSNLDE...	748	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8271
P01024-748-unknown	RSNLDE...	748	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8317
P01024-749-unknown	SNLDED...	749	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01024-749-unknown	SNLDED...	749	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27451
P01024-749-unknown	SNLDED...	749	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4747
P01024-749-unknown	SNLDED...	749	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8350
P01024-749-unknown	SNLDED...	749	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8436
P01024-749-unknown	SNLDED...	749		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-752-unknown	DEDIIA...	752	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4748
P01024-759-unknown	ENIVSR...	759	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8351
P01024-849-unknown	AVLYNY...	849		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-914-unknown	AAVYHH...	914		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-916-unknown	VYHHFI...	916		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-928-unknown	SLKVVP...	928		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-929-unknown	LKVVPE...	929		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-955-unknown	EGVQKE...	955	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01024-968-unknown	SDQVPD...	968		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-984-unknown	GTPVAQ...	984		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-984-	GTPVAQ...	984		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P01024-984-	GTPVAQ...	984		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P01024-988-unknown	AQMTED...	988	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8637
P01024-989-unknown	QMTEDA...	989		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-990-unknown	MTEDAV...	990	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8352
P01024-1002-unknown	HLIVTP...	1002	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01024-1136-unknown	NNEKDM...	1136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471384
P01024-1304-unknown	SSKITH...	1304	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8357
P01024-1307-unknown	ITHRIH...	1307	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469744
P01024-1311-unknown	IHWESA...	1311		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-1321-unknown	SEETKE...	1321	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01024-1321-unknown	SEETKE...	1321	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8358
P01024-1321-unknown	SEETKE...	1321		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-1331-unknown	TVTAEG...	1331		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-1338-unknown	GQGTLS...	1338		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-1351-unknown	KAKDQL...	1351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8638
P01024-1352-unknown	AKDQLT...	1352		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01024-1354-unknown	DQLTCN...	1354	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8353

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TPGSTV	144	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472044
...PQPAAR	667	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLGLAR	747	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLGLAR	747	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8271
...HLGLAR	747	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8317
...LGLARS	748	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LGLARS	748	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27451
...LGLARS	748	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4747
...LGLARS	748	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8350
...LGLARS	748	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8436
...ARSNLD	751	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4748
...DIIAEE	758	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8351
...ERLGRE	954	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QGTPVA	987	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8637
...TPVAQM	989	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8352
...AERLKH	1001	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QLPSRS	1303	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QLPSRS	1303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8357
...ASLLRS	1320	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8358
...TMYHAK	1350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8638
...HAKAKD	1353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8353
...AYYNLE	1485	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469744
...SMVVFG	1659	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471384
...FGCPN	1663	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CBPB2_HUMAN	747	GLAR.\|.RSNL	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
CBPN_HUMAN	747	GLAR.\|.RSNL	inferred from experiment	unknown	MEROPS		Merops CBPN_HUMAN -> CO3_HUMAN @747
PLMN_HUMAN	748	LARS.\|.SNLD	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> CO3_HUMAN @748
CATG_HUMAN	748	LARS.\|.SNLD	inferred from experiment	unknown	MEROPS	Colomb MG	Maison CM et al.:Proteolysis of C3 on U937 cell ... (S01.133)	1861080,
CFAB_HUMAN	748	LARS.\|.SNLD	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @748
CO2_HUMAN	748	LARS.\|.SNLD	inferred from experiment	unknown	MEROPS		Merops CO2_HUMAN -> CO3_HUMAN @748
CATG_HUMAN	751	SNLD.\|.DEDI	inferred from experiment	unknown	MEROPS	Colomb MG	Maison CM et al.:Proteolysis of C3 on U937 cell ... (S01.133)	1861080,
CFAB_HUMAN	758	IAEE.\|.ENIV	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @758
CFAB_HUMAN	758	IAEE.\|.ENIV	inferred from experiment	unknown	MEROPS	Vogel CW	O'Keefe MC et al.:A novel cleavage product of hum... (S01.196)	3045125,
ELNE_HUMAN	987	TPVA.\|.AQMT	inferred from experiment	unknown	MEROPS	Kalfas S	Claesson R et al.:A new cleavage site for elastas... (S01.131)	20854470,
CFAB_HUMAN	989	VAQM.\|.MTED	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @989
CFAB_HUMAN	989	VAQM.\|.MTED	inferred from experiment	unknown	MEROPS	Vogel CW	O'Keefe MC et al.:A novel cleavage product of hum... (S01.196)	3045125,
CFAI_HUMAN	1303	PSRS.\|.SSKI	inferred from experiment	unknown	MEROPS	Fey GH	de Bruijn MH et al.:Human complement component C3: ... (S01.199)	2579379,
CFAI_HUMAN	1320	LLRS.\|.SEET	inferred from experiment	unknown	MEROPS	Fey GH	de Bruijn MH et al.:Human complement component C3: ... (S01.199)	2579379,
ELNE_HUMAN	1350	YHAK.\|.KAKD	inferred from experiment	unknown	MEROPS	Kalfas S	Claesson R et al.:A new cleavage site for elastas... (S01.131)	20854470,
CFAB_HUMAN	1353	KAKD.\|.DQLT	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @1353
CFAB_HUMAN	1353	KAKD.\|.DQLT	inferred from experiment	unknown	MEROPS	Vogel CW	O'Keefe MC et al.:A novel cleavage product of hum... (S01.196)	3045125,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)