P06681: Complement C2
Protein names | - Complement C2 - 3.4.21.43 - C3/C5 convertase - Complement C2b fragment - Complement C2a fragment |
---|---|
Gene names | C2 |
Organism | Homo sapiens |
Protease Family | S01.194 |
Protease ID | S01.194 |
Chromosome location | |
UniProt ID | P06681 |
4
N-termini
2
C-termini
2
Cleavages
2
Substrates
Sequence
10 20 30 40 50 60
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS CPQGLYPSPA
70 80 90 100 110 120
SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY TPRLGSYPVG GNVSFECEDG
130 140 150 160 170 180
FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH CPNPGISLGA VRTGFRFGHG DKVRYRCSSN
190 200 210 220 230 240
LVLTGSSERE CQGNGVWSGT EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNPTQKTKES
250 260 270 280 290 300
LGRKIQIQRS GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS
310 320 330 340 350 360
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM NNQMRLLGME
370 380 390 400 410 420
TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ KRNDYLDIYA IGVGKLDVDW
430 440 450 460 470 480
RELNELGSKK DGERHAFILQ DTKALHQVFE HMLDVSKLTD TICGVGNMSA NASDQERTPW
490 500 510 520 530 540
HVTIKPKSQE TCRGALISDQ WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI
550 560 570 580 590 600
SPGFDVFAKK NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC
610 620 630 640 650 660
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP NLTDVREVVT
670 680 690 700 710 720
DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG LYNPCLGSAD KNSRKRAPRS
730 740 750
KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL PL
Isoforms
- Isoform 2 of Complement C2 - Isoform 3 of Complement C2Sequence View
10 20 30 40 50 60
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS CPQGLYPSPA
70 80 90 100 110 120
SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY TPRLGSYPVG GNVSFECEDG
130 140 150 160 170 180
FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH CPNPGISLGA VRTGFRFGHG DKVRYRCSSN
190 200 210 220 230 240
LVLTGSSERE CQGNGVWSGT EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNPTQKTKES
250 260 270 280 290 300
LGRKIQIQRS GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS
310 320 330 340 350 360
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM NNQMRLLGME
370 380 390 400 410 420
TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ KRNDYLDIYA IGVGKLDVDW
430 440 450 460 470 480
RELNELGSKK DGERHAFILQ DTKALHQVFE HMLDVSKLTD TICGVGNMSA NASDQERTPW
490 500 510 520 530 540
HVTIKPKSQE TCRGALISDQ WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI
550 560 570 580 590 600
SPGFDVFAKK NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC
610 620 630 640 650 660
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP NLTDVREVVT
670 680 690 700 710 720
DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG LYNPCLGSAD KNSRKRAPRS
730 740 750
KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL PL
10 20 30 40 50 60
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS CPQGLYPSPA
70 80 90 100 110 120
SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY TPRLGSYPVG GNVSFECEDG
130 140 150 160 170 180
FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH CPNPGISLGA VRTGFRFGHG DKVRYRCSSN
190 200 210 220 230 240
LVLTGSSERE CQGNGVWSGT EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNPTQKTKES
250 260 270 280 290 300
LGRKIQIQRS GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS
310 320 330 340 350 360
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM NNQMRLLGME
370 380 390 400 410 420
TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ KRNDYLDIYA IGVGKLDVDW
430 440 450 460 470 480
RELNELGSKK DGERHAFILQ DTKALHQVFE HMLDVSKLTD TICGVGNMSA NASDQERTPW
490 500 510 520 530 540
HVTIKPKSQE TCRGALISDQ WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI
550 560 570 580 590 600
SPGFDVFAKK NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC
610 620 630 640 650 660
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP NLTDVREVVT
670 680 690 700 710 720
DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG LYNPCLGSAD KNSRKRAPRS
730 740 750
KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL PL
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 2 Cleavages - 2 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P06681-21-unknown | APSCPQ... | 21 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P06681-63-unknown | LCKSSG... | 63 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
P06681-78-unknown | SLSKAV... | 78 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
P06681-244-unknown | KIQIQR... | 244 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P06681-244-unknown | KIQIQR... | 244 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16814 | |||
P06681-244-unknown | KIQIQR... | 244 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC710 | |||
P06681-244-unknown | KIQIQR... | 244 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116087 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ESLGRK | 243 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...ESLGRK | 243 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16814 | |||
...ESLGRK | 243 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC710 | |||
...ESLGRK | 243 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92078 | |||
...NFLPL | 752 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...NFLPL | 752 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt66884 | |||
...NFLPL | 752 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt66885 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MASP2_HUMAN | 243 | LGRK.|.KIQI | inferred from experiment | unknown | MEROPS | Fujita T | Matsushita M et al.:Proteolytic activities of two t... (S01.229) | 10946292, |
C1S_HUMAN | 243 | LGRK.|.KIQI | inferred from experiment | unknown | MEROPS | Merops C1S_HUMAN -> CO2_HUMAN @243 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CO3_HUMAN | 748 | LARS.|.SNLD | inferred from experiment | unknown | MEROPS | Merops CO2_HUMAN -> CO3_HUMAN @748 | ||
CO5_HUMAN | 751 | LGRL.|.LHMK | inferred from experiment | unknown | MEROPS | Merops CO2_HUMAN -> CO5_HUMAN @751 |