P01031: Complement C5
Protein names | - Complement C5 - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 - Complement C5 beta chain - Complement C5 alpha chain - C5a anaphylatoxin - Complement C5 alpha' chain |
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Gene names | C5 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | I39.952 |
Chromosome location | |
UniProt ID | P01031 |
7
N-termini
4
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF DATISIKSYP
70 80 90 100 110 120
DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS YVYLEVVSKH FSKSKRMPIT
130 140 150 160 170 180
YDNGFLFIHT DKPVYTPDQS VKVRVYSLND DLKPAKRETV LTFIDPEGSE VDMVEEIDHI
190 200 210 220 230 240
GIISFPDFKI PSNPRYGMWT IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY
250 260 270 280 290 300
KNFKNFEITI KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT
310 320 330 340 350 360
FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS PYKLNLVATP
370 380 390 400 410 420
LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE TSDLDPSKSV TRVDDGVASF
430 440 450 460 470 480
VLNLPSGVTV LEFNVKTDAP DLPEENQARE GYRAIAYSSL SQSYLYIDWT DNHKALLVGE
490 500 510 520 530 540
HLNIIVTPKS PYIDKITHYN YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL
550 560 570 580 590 600
LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV
610 620 630 640 650 660
ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG LTFLTNANAD
670 680 690 700 710 720
DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY DGACVNNDET CEQRAARISL
730 740 750 760 770 780
GPRCIKAFTE CCVVASQLRA NISHKDMQLG RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV
790 800 810 820 830 840
PRRKQLQFAL PDSLTTWEIQ GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ
850 860 870 880 890 900
LKGTVYNYRT SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV
910 920 930 940 950 960
LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY GTISRRKEFP
970 980 990 1000 1010 1020
YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL THLPKGSAEA ELMSVVPVFY
1030 1040 1050 1060 1070 1080
VFHYLETGNH WNIFHSDPLI EKQKLKKKLK EGMLSIMSYR NADYSYSVWK GGSASTWLTA
1090 1100 1110 1120 1130 1140
FALRVLGQVN KYVEQNQNSI CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN
1150 1160 1170 1180 1190 1200
SLYLTAFTVI GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK
1210 1220 1230 1240 1250 1260
THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET TAYALLTSLN
1270 1280 1290 1300 1310 1320
LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLLVKQLRLS MDIDVSYKHK
1330 1340 1350 1360 1370 1380
GALHNYKMTD KNFLGRPVEV LLNDDLIVST GFGSGLATVH VTTVVHKTST SEEVCSFYLK
1390 1400 1410 1420 1430 1440
IDTQDIEASH YRGYGNSDYK RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK
1450 1460 1470 1480 1490 1500
ALVEGVDQLF TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR
1510 1520 1530 1540 1550 1560
PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ TACKPEIAYA
1570 1580 1590 1600 1610 1620
YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF IKKVTCTNAE LVKGRQYLIM
1630 1640 1650 1660 1670
GKEALQIKYN FSFRYIYPLD SLTWIEYWPR DTTCSSCQAF LANLDEFAED IFLNGC
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
7 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P01031-19-unknown | QEQTYV... | 19 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P01031-678-unknown | TLQKKI... | 678 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P01031-751-unknown | RLHMKT... | 751 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8272 | |||
P01031-751-unknown | RLHMKT... | 751 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8318 | |||
P01031-752-unknown | LHMKTL... | 752 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P01031-752-unknown | LHMKTL... | 752 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27452 | |||
P01031-752-unknown | LHMKTL... | 752 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8354 | |||
P01031-752-unknown | LHMKTL... | 752 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8437 | |||
P01031-756-unknown | TLLPVS... | 756 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
P01031-948-unknown | GIYGTI... | 948 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
P01031-1393-unknown | GYGNSD... | 1393 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...CKEILR | 673 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...DMQLGR | 750 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8272 | |||
...DMQLGR | 750 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8318 | |||
...MQLGRL | 751 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...MQLGRL | 751 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27452 | |||
...MQLGRL | 751 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8354 | |||
...MQLGRL | 751 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8437 | |||
...FLNGC | 1676 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CBPB2_HUMAN | 750 | QLGR.|.RLHM | inferred from experiment | unknown | MEROPS | Leung LL | Myles T et al.:Thrombin activatable fibrinolys... (M14.009) | 14525995, |
CBPN_HUMAN | 750 | QLGR.|.RLHM | inferred from experiment | unknown | MEROPS | Merops CBPN_HUMAN -> CO5_HUMAN @750 | ||
PLMN_HUMAN | 751 | LGRL.|.LHMK | inferred from experiment | unknown | MEROPS | Merops PLMN_HUMAN -> CO5_HUMAN @751 | ||
CFAB_HUMAN | 751 | LGRL.|.LHMK | inferred from experiment | unknown | MEROPS | Merops CFAB_HUMAN -> CO5_HUMAN @751 | ||
CO2_HUMAN | 751 | LGRL.|.LHMK | inferred from experiment | unknown | MEROPS | Merops CO2_HUMAN -> CO5_HUMAN @751 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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