P00751: Complement factor B

General Information

Protein names	- Complement factor B - 3.4.21.47 - C3/C5 convertase - Glycine-rich beta glycoprotein - GBG - PBF2 - Properdin factor B - Complement factor B Ba fragment - Complement factor B Bb fragment
Gene names	CFB
Organism	Homo sapiens
Protease Family	S01.196
Protease ID	S01.196
Chromosome location
UniProt ID	P00751

6 N-termini

2 C-termini

1 Cleavages

5 Substrates

Sequence

        10         20         30         40         50         60
MGSNLSPQLC LMPFILGLLS GGVTTTPWSL ARPQGSCSLE GVEIKGGSFR LLQEGQALEY
        70         80         90        100        110        120
VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY
       130        140        150        160        170        180
YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ
       190        200        210        220        230        240
YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE
       250        260        270        280        290        300
TIEGVDAEDG HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGASNFTGAK KCLVNLIEKV
       310        320        330        340        350        360
ASYGVKPRYG LVTYATYPKI WVKVSEADSS NADWVTKQLN EINYEDHKLK SGTNTKKALQ
       370        380        390        400        410        420
AVYSMMSWPD DVPPEGWNRT RHVIILMTDG LHNMGGDPIT VIDEIRDLLY IGKDRKNPRE
       430        440        450        460        470        480
DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ HVFKVKDMEN LEDVFYQMID ESQSLSLCGM
       490        500        510        520        530        540
VWEHRKGTDY HKQPWQAKIS VIRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS
       550        560        570        580        590        600
VGGEKRDLEI EVVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLKYGQ TIRPICLPCT
       610        620        630        640        650        660
EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG DKKGSCERDA
       670        680        690        700        710        720
QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG GPLIVHKRSR FIQVGVISWG
       730        740        750        760
VVDVCKNQKR QKQVPAHARD FHINLFQVLP WLKEKLQDED LGFL

Isoforms

- Isoform 2 of Complement factor B

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 5 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P00751-1-unknown	MGSNLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70415
P00751-26-unknown	TPWSLA...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00751-26-unknown	TPWSLA...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114050
P00751-78-unknown	STGSWS...	78		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00751-78-unknown	STGSWS...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180303
P00751-260-unknown	KIVLDP...	260	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00751-260-unknown	KIVLDP...	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8355
P00751-260-unknown	KIVLDP...	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116104
P00751-394-unknown	MGGDPI...	394		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00751-394-unknown	MGGDPI...	394	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180305
P00751-396-unknown	GDPITV...	396		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00751-396-unknown	GDPITV...	396	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180307

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EQQKRK	259	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EQQKRK	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8355
...EQQKRK	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92137
...DLGFL	764	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CFAD_HUMAN	259	QKRK.\|.KIVL	inferred from experiment	unknown	MEROPS		Merops CFAD_HUMAN -> CFAB_HUMAN @259

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CO3_HUMAN	748	LARS.\|.SNLD	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @748
CO5_HUMAN	751	LGRL.\|.LHMK	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO5_HUMAN @751
CO3_HUMAN	758	IAEE.\|.ENIV	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @758
CO3_HUMAN	758	IAEE.\|.ENIV	inferred from experiment	unknown	MEROPS	Vogel CW	O'Keefe MC et al.:A novel cleavage product of hum... (S01.196)	3045125,
CO3_HUMAN	989	VAQM.\|.MTED	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @989
CO3_HUMAN	989	VAQM.\|.MTED	inferred from experiment	unknown	MEROPS	Vogel CW	O'Keefe MC et al.:A novel cleavage product of hum... (S01.196)	3045125,
CO3_HUMAN	1353	KAKD.\|.DQLT	inferred from experiment	unknown	MEROPS		Merops CFAB_HUMAN -> CO3_HUMAN @1353
CO3_HUMAN	1353	KAKD.\|.DQLT	inferred from experiment	unknown	MEROPS	Vogel CW	O'Keefe MC et al.:A novel cleavage product of hum... (S01.196)	3045125,