P15169: Carboxypeptidase N catalytic chain
Protein names | - Carboxypeptidase N catalytic chain - CPN - 3.4.17.3 - Anaphylatoxin inactivator - Arginine carboxypeptidase - Carboxypeptidase N polypeptide 1 - Carboxypeptidase N small subunit - Kininase-1 - Lysine carboxypeptidase - Plasma carboxypeptidase B - Serum carboxypeptidase N - SCPN |
---|---|
Gene names | CPN1 |
Organism | Homo sapiens |
Protease Family | M14.004 |
Protease ID | M14.004 |
Chromosome location | |
UniProt ID | P15169 |
3
N-termini
3
C-termini
1
Cleavages
21
Substrates
Sequence
10 20 30 40 50 60
MSDLLSVFLH LLLLFKLVAP VTFRHHRYDD LVRTLYKVQN ECPGITRVYS IGRSVEGRHL
70 80 90 100 110 120
YVLEFSDHPG IHEPLEPEVK YVGNMHGNEA LGRELMLQLS EFLCEEFRNR NQRIVQLIQD
130 140 150 160 170 180
TRIHILPSMN PDGYEVAAAQ GPNKPGYLVG RNNANGVDLN RNFPDLNTYI YYNEKYGGPN
190 200 210 220 230 240
HHLPLPDNWK SQVEPETRAV IRWMHSFNFV LSANLHGGAV VANYPYDKSF EHRVRGVRRT
250 260 270 280 290 300
ASTPTPDDKL FQKLAKVYSY AHGWMFQGWN CGDYFPDGIT NGASWYSLSK GMQDFNYLHT
310 320 330 340 350 360
NCFEITLELS CDKFPPEEEL QREWLGNREA LIQFLEQVHQ GIKGMVLDEN YNNLANAVIS
370 380 390 400 410 420
VSGINHDVTS GDHGDYFRLL LPGIYTVSAT APGYDPETVT VTVGPAEPTL VNFHLKRSIP
430 440 450
QVSPVRRAPS RRHGVRAKVQ PQARKKEMEM RQLQRGPA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 1 Cleavages - 21 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P15169-21-unknown | VTFRHH... | 21 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P15169-204-unknown | MHSFNF... | 204 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000410895 | |||
P15169-239-unknown | RTASTP... | 239 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27547 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VRGVRR | 238 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27547 | |||
...VGPAEP | 407 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000410895 | |||
...QRGPA | 458 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PLMN_HUMAN | 238 | GVRR.|.RTAS | inferred from experiment | unknown | MEROPS | Skidgel RA | Quagraine MO et al.:Plasmin alters the activity and... (S01.233) | 15617514, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
FIBG_HUMAN | 87 | QLIK.|.KAIQ | inferred from experiment | unknown | MEROPS | Leung LL | Myles T et al.:Thrombin activatable fibrinolys... (M14.009) | 14525995, |
FIBG-Isoform2_HUMAN | 87 | QLIK.|.KAIQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8323 | ||
SDF1_HUMAN | 88 | ALNK.|.KRFK | inferred from experiment | unknown | MEROPS | Tosato G | Davis DA et al.:Identification of carboxypeptid... (M14.004) | 15718415, |
S10AA_HUMAN | 95 | QKGK.|.KK | inferred from experiment | unknown | MEROPS | Waisman DM | Fogg DK et al.:The p11 subunit of annexin II h... (M14.009) | 11939791, |
S10AA_HUMAN | 96 | KGKK.|.K | inferred from experiment | unknown | MEROPS | Waisman DM | Fogg DK et al.:The p11 subunit of annexin II h... (M14.009) | 11939791, |
FIBG_HUMAN | 110 | ATLK.|.KSRK | inferred from experiment | unknown | MEROPS | Leung LL | Myles T et al.:Thrombin activatable fibrinolys... (M14.009) | 14525995, |
FIBG-Isoform2_HUMAN | 110 | ATLK.|.KSRK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8325 | ||
OSTP-Isoform3_HUMAN | 140 | YGLR.|.RSKS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8329 | ||
HBA_HUMAN | 141 | SKYR.|.R | inferred from experiment | unknown | MEROPS | Erdos EG | Michel B et al.:Removal of Arg141 from the alph... (M14.006) | 8635221, |
OSTP-Isoform4_HUMAN | 145 | YGLR.|.RSKS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8329 | ||
OSTP-Isoform5_HUMAN | 153 | YGLR.|.RSKS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8329 | ||
OSTP-Isoform2_HUMAN | 153 | YGLR.|.RSKS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8329 | ||
OSTP_HUMAN | 167 | YGLR.|.RSKS | inferred from experiment | unknown | MEROPS | Leung LL | Myles T et al.:Thrombin activatable fibrinolys... (M14.009) | 14525995, |
FIBB_HUMAN | 177 | ELEK.|.KHQL | inferred from experiment | unknown | MEROPS | Leung LL | Myles T et al.:Thrombin activatable fibrinolys... (M14.009) | 14525995, |
KNG1-Isoform3_HUMAN | 352 | SPFR.|.RSSR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8319 | ||
KNG1_HUMAN | 388 | SPFR.|.RSSR | inferred from experiment | unknown | MEROPS | Merops CBPN_HUMAN -> KNG1_HUMAN @388 | ||
KNG1-Isoform2_HUMAN | 388 | SPFR.|.RSSR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8319 | ||
CO3_HUMAN | 747 | GLAR.|.RSNL | inferred from experiment | unknown | MEROPS | Merops CBPN_HUMAN -> CO3_HUMAN @747 | ||
CO5_HUMAN | 750 | QLGR.|.RLHM | inferred from experiment | unknown | MEROPS | Merops CBPN_HUMAN -> CO5_HUMAN @750 | ||
CO4A-Isoform2_HUMAN | 755 | GLQR.|.RALE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8327 | ||
CO4A_HUMAN | 755 | GLQR.|.RALE | inferred from experiment | unknown | MEROPS | Merops CBPN_HUMAN -> CO4A_HUMAN @755 |