P01042: Kininogen-1

General Information

Protein names	- Kininogen-1 - Alpha-2-thiol proteinase inhibitor - Fitzgerald factor - High molecular weight kininogen - HMWK - Williams-Fitzgerald-Flaujeac factor - Kininogen-1 heavy chain - T-kinin - Ile-Ser-Bradykinin - Bradykinin - Kallidin I - Lysyl-bradykinin - Kallidin II - Kininogen-1 light chain - Low molecular weight growth-promoting factor
Gene names	KNG1
Organism	Homo sapiens
Protease Family
Protease ID	I25.016
Chromosome location
UniProt ID	P01042

30 N-termini

24 C-termini

55 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform LMW of Kininogen-1 - Isoform 3 of Kininogen-1

Sequence View

        10         20         30         40         50         60
MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT
        70         80         90        100        110        120
EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS
       130        140        150        160        170        180
VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN
       190        200        210        220        230        240
EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR
       250        260        270        280        290        300
IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK
       310        320        330        340        350        360
IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW
       370        380        390        400        410        420
EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TVSPPHTSMA PAQDEERDSG
       430        440        450        460        470        480
KEQGHTRRHD WGHEKQRKHN LGHGHKHERD QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD
       490        500        510        520        530        540
DDLEHQGGHV LDHGHKHKHG HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE
       550        560        570        580        590        600
KTEGPTPIPS LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF
       610        620        630        640
NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS         10         20         30         40         50         60
MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT
        70         80         90        100        110        120
EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS
       130        140        150        160        170        180
VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN
       190        200        210        220        230        240
EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR
       250        260        270        280        290        300
IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK
       310        320        330        340        350        360
IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW
       370        380        390        400        410        420
EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TVSPPHTSMA PAQDEERDSG
       430        440        450        460        470        480
KEQGHTRRHD WGHEKQRKHN LGHGHKHERD QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD
       490        500        510        520        530        540
DDLEHQGGHV LDHGHKHKHG HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE
       550        560        570        580        590        600
KTEGPTPIPS LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF
       610        620        630        640
NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01042-1-unknown	MKLITI...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79195
P01042-1-unknown	MKLITI...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79196
P01042-19-Pyrrolidone carboxylic acid	QESQSE...	19	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01042-19-Pyrrolidone carboxylic acid	QESQSE...	19	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112102
P01042-19-Pyrrolidone carboxylic acid	QESQSE...	19	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112103
P01042-115-unknown	SSTKFS...	115		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15909
P01042-115-unknown	SSTKFS...	115		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143221
P01042-115-unknown	SSTKFS...	115		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143222
P01042-241-unknown	IASFSQ...	241		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16406
P01042-241-unknown	IASFSQ...	241		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146699
P01042-241-unknown	IASFSQ...	241		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148116
P01042-243-unknown	SFSQNC...	243			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01042-243-unknown	SFSQNC...	243		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180530
P01042-243-unknown	SFSQNC...	243		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180531
P01042-270-unknown	DIPTNS...	270		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16409
P01042-270-unknown	DIPTNS...	270		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147866
P01042-270-unknown	DIPTNS...	270		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149107
P01042-290-unknown	NAENNA...	290		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4329
P01042-290-unknown	NAENNA...	290		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148614
P01042-290-unknown	NAENNA...	290		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149590
P01042-316-unknown	KYFIDF...	316			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01042-316-unknown	KYFIDF...	316		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180533
P01042-316-unknown	KYFIDF...	316		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180534
P01042-317-unknown	YFIDFV...	317		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4332
P01042-317-unknown	YFIDFV...	317			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01042-317-unknown	YFIDFV...	317		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149389
P01042-317-unknown	YFIDFV...	317		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150277
P01042-318-unknown	FIDFVA...	318			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01042-318-unknown	FIDFVA...	318		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180536
P01042-318-unknown	FIDFVA...	318		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180537
P01042-322-unknown	VARETT...	322		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4335
P01042-322-unknown	VARETT...	322		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149500
P01042-322-unknown	VARETT...	322		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150400
P01042-377-unknown	SLMKRP...	377		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8641
P01042-377-unknown	SLMKRP...	377		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150763
P01042-377-unknown	SLMKRP...	377		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151562
P01042-380-unknown	KRPPGF...	380		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC861
P01042-380-unknown	KRPPGF...	380		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC715
P01042-380-unknown	KRPPGF...	380		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150822
P01042-380-unknown	KRPPGF...	380		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151608
P01042-381-unknown	RPPGFS...	381		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16688
P01042-381-unknown	RPPGFS...	381		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16706
P01042-381-unknown	RPPGFS...	381		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9552
P01042-381-unknown	RPPGFS...	381		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16033
P01042-381-unknown	RPPGFS...	381		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC232
P01042-381-unknown	RPPGFS...	381		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC249
P01042-381-unknown	RPPGFS...	381		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150839
P01042-381-unknown	RPPGFS...	381		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151638
P01042-382-unknown	PPGFSP...	382		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15180
P01042-382-unknown	PPGFSP...	382		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32153
P01042-382-unknown	PPGFSP...	382		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32161
P01042-383-unknown	PGFSPF...	383		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8461
P01042-383-unknown	PGFSPF...	383		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27611
P01042-384-unknown	GFSPFR...	384		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31890
P01042-384-unknown	GFSPFR...	384		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27614
P01042-385-unknown	FSPFRS...	385		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26669
P01042-385-unknown	FSPFRS...	385		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4984
P01042-385-unknown	FSPFRS...	385		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27632
P01042-386-unknown	SPFRSS...	386		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16993
P01042-386-unknown	SPFRSS...	386		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4963
P01042-386-unknown	SPFRSS...	386		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31681
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26672
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8517
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8583
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26794
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19896
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15552
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24794
P01042-388-unknown	FRSSRI...	388		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27617
P01042-389-unknown	RSSRIG...	389		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8273
P01042-389-unknown	RSSRIG...	389		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8308
P01042-389-unknown	RSSRIG...	389		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8319
P01042-389-unknown	RSSRIG...	389		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8374
P01042-389-unknown	RSSRIG...	389		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24797
P01042-390-unknown	SSRIGE...	390		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01042-390-unknown	SSRIGE...	390		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16691
P01042-390-unknown	SSRIGE...	390		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15183
P01042-390-unknown	SSRIGE...	390		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC864
P01042-390-unknown	SSRIGE...	390		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16036
P01042-390-unknown	SSRIGE...	390		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC718
P01042-393-unknown	IGEIKE...	393		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16412
P01042-394-unknown	GEIKEE...	394		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8644
P01042-428-unknown	RHDWGH...	428		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16694
P01042-428-unknown	RHDWGH...	428		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16039
P01042-438-unknown	KHNLGH...	438		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15186
P01042-438-unknown	KHNLGH...	438		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16040
P01042-450-unknown	DQGHGH...	450		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31967
P01042-458-unknown	GHGLGH...	458		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16041
P01042-597-unknown	GLSFNP...	597			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01042-599-unknown	SFNPIS...	599			unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TVGKRS	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15909
...TVGKRS	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126447
...TVGKRS	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126448
...DIQLRI	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16406
...DIQLRI	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131481
...VGCPRD	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16409
...VGCPRD	269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131221
...VGCPRD	269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132492
...TITKLN	289	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4329
...TITKLN	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131988
...TITKLN	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132978
...VAGKKY	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4332
...VAGKKY	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132773
...VAGKKY	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133672
...YFIDFV	321	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4335
...YFIDFV	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132885
...YFIDFV	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133797
...PLGMIS	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8641
...PLGMIS	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134163
...PLGMIS	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134967
...MISLMK	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC861
...MISLMK	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC715
...MISLMK	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134224
...MISLMK	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135015
...ISLMKR	380	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ISLMKR	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16688
...ISLMKR	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16706
...ISLMKR	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9552
...ISLMKR	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16033
...ISLMKR	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC232
...ISLMKR	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC249
...ISLMKR	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92601
...ISLMKR	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92602
...SLMKRP	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15180
...SLMKRP	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32153
...SLMKRP	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32161
...SLMKRP	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134267
...SLMKRP	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135072
...LMKRPP	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8461
...LMKRPP	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27611
...LMKRPP	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134283
...LMKRPP	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135094
...MKRPPG	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31890
...MKRPPG	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27614
...MKRPPG	383	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134307
...MKRPPG	383	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135124
...KRPPGF	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26669
...KRPPGF	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4984
...KRPPGF	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27632
...KRPPGF	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134318
...KRPPGF	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135134
...RPPGFS	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16993
...RPPGFS	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4963
...RPPGFS	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31681
...RPPGFS	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134339
...RPPGFS	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135167
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26672
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8517
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8583
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26794
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19896
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15552
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24794
...PGFSPF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27617
...PGFSPF	387	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134376
...PGFSPF	387	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135197
...GFSPFR	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8273
...GFSPFR	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8308
...GFSPFR	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8319
...GFSPFR	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8374
...GFSPFR	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24797
...GFSPFR	388	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134410
...GFSPFR	388	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135220
...FSPFRS	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16691
...FSPFRS	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15183
...FSPFRS	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC864
...FSPFRS	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16036
...FSPFRS	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC718
...FSPFRS	389	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134432
...FSPFRS	389	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135242
...FRSSRI	392	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16412
...RSSRIG	393	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8644
...QGHTRR	427	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16694
...QGHTRR	427	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16039
...HEKQRK	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15186
...HEKQRK	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16040
...HKHERD	449	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31967
...HGHQRG	457	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16041
...TDGLS	644	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK14_HUMAN	114	GKRS.\|.SSTK	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Expression and functional chara... (S01.029)	17110383,
KLK5_HUMAN	240	QLRI.\|.IASF	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
KLK5_HUMAN	269	CPRD.\|.DIPT	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
CATD_HUMAN	289	TKLN.\|.NAEN	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,
CATD_HUMAN	316	GKKY.\|.YFID	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,
CATD_HUMAN	321	IDFV.\|.VARE	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,
ELNE_HUMAN	376	GMIS.\|.SLMK	inferred from experiment	unknown	MEROPS	Travis J	Imamura T et al.:Activation of the kallikrein-ki... (C02.001)	15576318,
CAN2_HUMAN	379	SLMK.\|.KRPP	inferred from experiment	unknown	MEROPS	Travis J	Imamura T et al.:Activation of the kallikrein-ki... (C02.001)	15576318,
CAN1_HUMAN	379	SLMK.\|.KRPP	inferred from experiment	unknown	MEROPS	Travis J	Imamura T et al.:Activation of the kallikrein-ki... (C02.001)	15576318,
KLKB1_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops KLKB1_HUMAN -> KNG1_HUMAN @380
LCAP_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops LCAP_HUMAN -> KNG1_HUMAN @380
ERAP2_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS	Tsujimoto M	Tanioka T et al.:Human leukocyte-derived arginin... (M01.024)	12799365,
KLK2_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops KLK2_HUMAN -> KNG1_HUMAN @380
AMPE_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS	Tsujimoto M	Goto Y et al.:Asparatic acid 221 is critical ... (M01.003)	17932029,
AMPQ_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS	Tsujimoto M	Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)	17525158,
HABP2_HUMAN	381	MKRP.\|.PPGF	inferred from experiment	unknown	MEROPS	Johannes D	Etscheid M et al.:The hyaluronan-binding serine p... (S01.033)	12452440,
XPP1_HUMAN	381	MKRP.\|.PPGF	inferred from experiment	unknown	MEROPS	Mentlein R	Harbeck HT et al.:Aminopeptidase P from rat brain... (M24.009)	1645659,
XPP2_HUMAN	381	MKRP.\|.PPGF	inferred from experiment	unknown	MEROPS	Adam A	Molinaro G et al.:Human recombinant membrane-boun... (M24.005)	15361070,
DPP2_HUMAN	382	KRPP.\|.PGFS	inferred from experiment	unknown	MEROPS		Merops DPP2_HUMAN -> KNG1_HUMAN @382
PPCE_HUMAN	382	KRPP.\|.PGFS	inferred from experiment	unknown	MEROPS		Merops PPCE_HUMAN -> KNG1_HUMAN @382
TPP1_HUMAN	383	RPPG.\|.GFSP	inferred from experiment	unknown	MEROPS	Oda K	Oyama H et al.:Catalytic residues and substrat... (S53.003)	16091586,
PPCE_HUMAN	383	RPPG.\|.GFSP	inferred from experiment	unknown	MEROPS	Walter R	Koida M et al.:Post-proline cleaving enzyme. P... (S09.001)	12173,
NEP_HUMAN	384	PPGF.\|.FSPF	inferred from experiment	unknown	MEROPS	Turner AJ	Matsas R et al.:The metabolism of neuropeptides... (M13.001)	6149747,
CATK_HUMAN	384	PPGF.\|.FSPF	inferred from experiment	unknown	MEROPS	Lalmanach G	Godat E et al.:Cathepsin K: a cysteine proteas... (C01.036)	15265002,
PREP_HUMAN	384	PPGF.\|.FSPF	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
MEP1A_HUMAN	385	PGFS.\|.SPFR	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
CATH_HUMAN	385	PGFS.\|.SPFR	inferred from experiment	unknown	MEROPS	Popovic T	Brguljan PM et al.:Human brain cathepsin H as a ne... (C01.040)	15127951,
THOP1_HUMAN	385	PGFS.\|.SPFR	inferred from experiment	unknown	MEROPS		Merops THOP1_HUMAN -> KNG1_HUMAN @385
ACE2_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Tummino P	Vickers C et al.:Hydrolysis of biological peptid... (M02.006)	11815627,
NEP_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Turner AJ	Matsas R et al.:The metabolism of neuropeptides... (M13.001)	6149747,
ECE1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> KNG1_HUMAN @387
ECE1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> KNG1_HUMAN @387
ECE2_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
PCP_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS		Merops PCP_HUMAN -> KNG1_HUMAN @387
MMEL1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Ouimet T	Rose C et al.:Cell-specific activity of nepri... (M13.008)	11964170,
IDE_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Tang WJ	Malito E et al.:Molecular bases for the recogni... (M16.002)	18986166,
MMP8_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Tschesche H	Diekmann O et al.:Degradation of kinins, angioten... (M10.002)	7538373,
PPCE_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Syed SA	Makinen PL et al.:Role of the chymotrypsin-like m... (S09.001)	7543886,
CBPB2_HUMAN	388	SPFR.\|.RSSR	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
CBPM_HUMAN	388	SPFR.\|.RSSR	inferred from experiment	unknown	MEROPS		Merops CBPM_HUMAN -> KNG1_HUMAN @388
CBPN_HUMAN	388	SPFR.\|.RSSR	inferred from experiment	unknown	MEROPS		Merops CBPN_HUMAN -> KNG1_HUMAN @388
CMA1_HUMAN	388	SPFR.\|.RSSR	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
MMP8_HUMAN	388	SPFR.\|.RSSR	inferred from experiment	unknown	MEROPS	Tschesche H	Diekmann O et al.:Degradation of kinins, angioten... (M10.002)	7538373,
KLKB1_HUMAN	389	PFRS.\|.SSRI	inferred from experiment	unknown	MEROPS		Merops KLKB1_HUMAN -> KNG1_HUMAN @389
HABP2_HUMAN	389	PFRS.\|.SSRI	inferred from experiment	unknown	MEROPS	Johannes D	Etscheid M et al.:The hyaluronan-binding serine p... (S01.033)	12452440,
CAN2_HUMAN	389	PFRS.\|.SSRI	inferred from experiment	unknown	MEROPS	Travis J	Imamura T et al.:Activation of the kallikrein-ki... (C02.001)	15576318,
KLK2_HUMAN	389	PFRS.\|.SSRI	inferred from experiment	unknown	MEROPS		Merops KLK2_HUMAN -> KNG1_HUMAN @389
CAN1_HUMAN	389	PFRS.\|.SSRI	inferred from experiment	unknown	MEROPS	Travis J	Imamura T et al.:Activation of the kallikrein-ki... (C02.001)	15576318,
KLK5_HUMAN	392	SSRI.\|.IGEI	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
ELNE_HUMAN	393	SRIG.\|.GEIK	inferred from experiment	unknown	MEROPS	Travis J	Imamura T et al.:Activation of the kallikrein-ki... (C02.001)	15576318,
KLKB1_HUMAN	427	HTRR.\|.RHDW	inferred from experiment	unknown	MEROPS	Tindall DJ	Charlesworth MC et al.:Kininogenase activity of prosta... (S01.161)	10232657,
KLK2_HUMAN	427	HTRR.\|.RHDW	inferred from experiment	unknown	MEROPS	Tindall DJ	Charlesworth MC et al.:Kininogenase activity of prosta... (S01.161)	10232657,
HABP2_HUMAN	437	KQRK.\|.KHNL	inferred from experiment	unknown	MEROPS	Johannes D	Etscheid M et al.:The hyaluronan-binding serine p... (S01.033)	12452440,
KLK2_HUMAN	437	KQRK.\|.KHNL	inferred from experiment	unknown	MEROPS	Tindall DJ	Charlesworth MC et al.:Kininogenase activity of prosta... (S01.161)	10232657,
TRYB1_HUMAN	449	HERD.\|.DQGH	inferred from experiment	unknown	MEROPS		Merops TRYB1_HUMAN -> KNG1_HUMAN @449
KLK2_HUMAN	457	HQRG.\|.GHGL	inferred from experiment	unknown	MEROPS	Tindall DJ	Charlesworth MC et al.:Kininogenase activity of prosta... (S01.161)	10232657,

TopFIND

P01042: Kininogen-1

General Information

30

N-termini

24

C-termini

55

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

30 N-termini - 24 C-termini - 55 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates