P42892: Endothelin-converting enzyme 1

General Information

Protein names	- Endothelin-converting enzyme 1 - ECE-1 - 3.4.24.71
Gene names	ECE1
Organism	Homo sapiens
Protease Family	M13.002
Protease ID	M13.002
Chromosome location
UniProt ID	P42892

6 N-termini

1 C-termini

0 Cleavages

68 Substrates

Sequence

Isoforms

- Isoform A of Endothelin-converting enzyme 1 - Isoform C of Endothelin-converting enzyme 1 - Isoform D of Endothelin-converting enzyme 1

Sequence View

        10         20         30         40         50         60
MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH SPRSGQRCWA
        70         80         90        100        110        120
ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL SEACVSVTSS ILSSMDPTVD
       130        140        150        160        170        180
PCHDFFSYAC GGWIKANPVP DGHSRWGTFS NLWEHNQAII KHLLENSTAS VSEAERKAQV
       190        200        210        220        230        240
YYRACMNETR IEELRAKPLM ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY
       250        260        270        280        290        300
VSADSKNSNS NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI
       310        320        330        340        350        360
RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP FLNTIFYPVE
       370        380        390        400        410        420
INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR KTSSFLDQRF QDADEKFMEV
       430        440        450        460        470        480
MYGTKKTCLP RWKFCVSDTE NNLGFALGPM FVKATFAEDS KSIATEIILE IKKAFEESLS
       490        500        510        520        530        540
TLKWMDEETR KSAKEKADAI YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF
       550        560        570        580        590        600
SWRVTADQLR KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG
       610        620        630        640        650        660
IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS NYSVNGEPVN
       670        680        690        700        710        720
GRHTLGENIA DNGGLKAAYR AYQNWVKKNG AEHSLPTLGL TNNQLFFLGF AQVWCSVRTP
       730        740        750        760        770
ESSHEGLITD PHSPSRFRVI GSLSNSKEFS EHFRCPPGSP MNPPHKCEVW         10         20         30         40         50         60
MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH SPRSGQRCWA
        70         80         90        100        110        120
ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL SEACVSVTSS ILSSMDPTVD
       130        140        150        160        170        180
PCHDFFSYAC GGWIKANPVP DGHSRWGTFS NLWEHNQAII KHLLENSTAS VSEAERKAQV
       190        200        210        220        230        240
YYRACMNETR IEELRAKPLM ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY
       250        260        270        280        290        300
VSADSKNSNS NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI
       310        320        330        340        350        360
RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP FLNTIFYPVE
       370        380        390        400        410        420
INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR KTSSFLDQRF QDADEKFMEV
       430        440        450        460        470        480
MYGTKKTCLP RWKFCVSDTE NNLGFALGPM FVKATFAEDS KSIATEIILE IKKAFEESLS
       490        500        510        520        530        540
TLKWMDEETR KSAKEKADAI YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF
       550        560        570        580        590        600
SWRVTADQLR KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG
       610        620        630        640        650        660
IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS NYSVNGEPVN
       670        680        690        700        710        720
GRHTLGENIA DNGGLKAAYR AYQNWVKKNG AEHSLPTLGL TNNQLFFLGF AQVWCSVRTP
       730        740        750        760        770
ESSHEGLITD PHSPSRFRVI GSLSNSKEFS EHFRCPPGSP MNPPHKCEVW         10         20         30         40         50         60
MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH SPRSGQRCWA
        70         80         90        100        110        120
ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL SEACVSVTSS ILSSMDPTVD
       130        140        150        160        170        180
PCHDFFSYAC GGWIKANPVP DGHSRWGTFS NLWEHNQAII KHLLENSTAS VSEAERKAQV
       190        200        210        220        230        240
YYRACMNETR IEELRAKPLM ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY
       250        260        270        280        290        300
VSADSKNSNS NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI
       310        320        330        340        350        360
RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP FLNTIFYPVE
       370        380        390        400        410        420
INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR KTSSFLDQRF QDADEKFMEV
       430        440        450        460        470        480
MYGTKKTCLP RWKFCVSDTE NNLGFALGPM FVKATFAEDS KSIATEIILE IKKAFEESLS
       490        500        510        520        530        540
TLKWMDEETR KSAKEKADAI YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF
       550        560        570        580        590        600
SWRVTADQLR KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG
       610        620        630        640        650        660
IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS NYSVNGEPVN
       670        680        690        700        710        720
GRHTLGENIA DNGGLKAAYR AYQNWVKKNG AEHSLPTLGL TNNQLFFLGF AQVWCSVRTP
       730        740        750        760        770
ESSHEGLITD PHSPSRFRVI GSLSNSKEFS EHFRCPPGSP MNPPHKCEVW

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 68 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42892-1-unknown	MRGVWP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42892-18-unknown	MSTYKR...	18	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P42892-18-unknown	MSTYKR...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195124
P42892-18-unknown	MSTYKR...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195123
P42892-34-	SLSEGD...	34		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P42892-34-	SLSEGD...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P42892-34-	SLSEGD...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P42892-34-unknown	SLSEGD...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165654
P42892-34-unknown	SLSEGD...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165653
P42892-568-	YYSPTK...	568		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P42892-568-unknown	YYSPTK...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176763
P42892-568-unknown	YYSPTK...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176764
P42892-568-unknown	YYSPTK...	568	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176762

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KCEVW	770	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KCEVW	770	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69188
...KCEVW	770	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69187
...KCEVW	770	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69189

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_HUMAN	36	DRVY.\|.YIHP	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
ANGT_HUMAN	37	RVYI.\|.IHPF	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
ANGT_HUMAN	40	IHPF.\|.FHLV	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
EDN1_HUMAN	57	CSSL.\|.LMDK	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
TKN1-Isoform4_HUMAN	63	PQQF.\|.FFGL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8571
TKN1-Isoform3_HUMAN	63	PQQF.\|.FFGL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8571
TKN1-Isoform2_HUMAN	63	PQQF.\|.FFGL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8571
TKN1_HUMAN	63	PQQF.\|.FFGL	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
TKN1-Isoform2_HUMAN	64	QQFF.\|.FGLM	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8575
TKN1_HUMAN	64	QQFF.\|.FGLM	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> TKN1_HUMAN @64
EDN1_HUMAN	65	CVYF.\|.FCHL	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
TKN1_HUMAN	66	FFGL.\|.LMGK	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
TKN1-Isoform2_HUMAN	66	FFGL.\|.LMGK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8577
EDN1_HUMAN	66	VYFC.\|.CHLD	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
EDN2_HUMAN	69	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
EDN1_HUMAN	70	HLDI.\|.IIWV	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
EDN1_HUMAN	71	LDII.\|.IWVN	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
EDN1_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> EDN1_HUMAN @73
EDN1_HUMAN	79	PEHV.\|.VVPY	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
EDN1_HUMAN	86	GLGS.\|.SPRS	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
EDN3-Isoform3_HUMAN	117	IIWI.\|.INTP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8568
EDN3-Isoform2_HUMAN	117	IIWI.\|.INTP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8568
EDN3_HUMAN	117	IIWI.\|.INTP	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> EDN3_HUMAN @117
NEUT_HUMAN	152	RQLY.\|.YENK	inferred from experiment	unknown	MEROPS	Turner AJ	Carson JA et al.:Characterization of PgPepO, a b... (M13.002)	12193062,
NEUT_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> NEUT_HUMAN @160
KNG1-Isoform3_HUMAN	351	FSPF.\|.FRSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8517
KNG1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> KNG1_HUMAN @387
KNG1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> KNG1_HUMAN @387
KNG1-Isoform2_HUMAN	387	FSPF.\|.FRSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8517
A4-Isoform10_HUMAN	543	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform10_HUMAN	556	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform10_HUMAN	557	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform10_HUMAN	559	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform3_HUMAN	581	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform3_HUMAN	594	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform3_HUMAN	595	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform3_HUMAN	597	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform4_HUMAN	599	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform5_HUMAN	600	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform4_HUMAN	612	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform5_HUMAN	613	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform4_HUMAN	613	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform5_HUMAN	614	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform4_HUMAN	615	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform5_HUMAN	616	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform6_HUMAN	618	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform6_HUMAN	631	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform6_HUMAN	632	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform6_HUMAN	634	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform7_HUMAN	637	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform11_HUMAN	650	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform7_HUMAN	650	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform7_HUMAN	651	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform7_HUMAN	653	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform8_HUMAN	655	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform9_HUMAN	656	DAEF.\|.FRHD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8520
A4-Isoform11_HUMAN	663	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform11_HUMAN	664	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform11_HUMAN	666	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform8_HUMAN	668	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform9_HUMAN	669	HQKL.\|.LVFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8530
A4-Isoform8_HUMAN	669	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform9_HUMAN	670	QKLV.\|.VFFA	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8540
A4-Isoform8_HUMAN	671	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4-Isoform9_HUMAN	672	LVFF.\|.FAED	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8550
A4_HUMAN	674	DAEF.\|.FRHD	inferred from experiment	unknown	MEROPS	Lee JM	Yan P et al.:Matrix metalloproteinase-9 degr... (M13.002)	16787929,
A4_HUMAN	687	HQKL.\|.LVFF	inferred from experiment	unknown	MEROPS	Lee JM	Yan P et al.:Matrix metalloproteinase-9 degr... (M13.002)	16787929,
A4_HUMAN	688	QKLV.\|.VFFA	inferred from experiment	unknown	MEROPS	Lee JM	Yan P et al.:Matrix metalloproteinase-9 degr... (M13.002)	16787929,
A4_HUMAN	690	LVFF.\|.FAED	inferred from experiment	unknown	MEROPS	Lee JM	Yan P et al.:Matrix metalloproteinase-9 degr... (M13.002)	16787929,