P05305: Endothelin-1

General Information

Protein names	- Endothelin-1 - Preproendothelin-1 - PPET1 - Endothelin-1 - ET-1 - Big endothelin-1
Gene names	EDN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05305

16 N-termini

16 C-termini

27 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD
        70         80         90        100        110        120
KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW
       130        140        150        160        170        180
NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE
       190        200        210
TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 16 C-termini - 27 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05305-53-unknown	CSCSSL...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27281
P05305-53-unknown	CSCSSL...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9708
P05305-58-unknown	LMDKEC...	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26722
P05305-58-unknown	LMDKEC...	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8560
P05305-66-unknown	FCHLDI...	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8561
P05305-67-unknown	CHLDII...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8562
P05305-69-unknown	LDIIWV...	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26723
P05305-71-unknown	IIWVNT...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26724
P05305-71-unknown	IIWVNT...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8563
P05305-72-unknown	IWVNTP...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8217
P05305-72-unknown	IWVNTP...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8564
P05305-73-unknown	WVNTPE...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8218
P05305-74-unknown	VNTPEH...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4714
P05305-74-unknown	VNTPEH...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8565
P05305-74-unknown	VNTPEH...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8588
P05305-74-unknown	VNTPEH...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15787
P05305-74-unknown	VNTPEH...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19923
P05305-80-unknown	VVPYGL...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8566
P05305-84-unknown	GLGSPR...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8413
P05305-85-unknown	LGSPRS...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25633
P05305-85-unknown	LGSPRS...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22453
P05305-87-unknown	SPRSKR...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8567
P05305-93-unknown	ALENLL...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27282
P05305-93-unknown	ALENLL...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9709
P05305-109-unknown	CQCASQ...	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9710
P05305-169-unknown	SSEEHL...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27283
P05305-169-unknown	SSEEHL...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9711

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRSKRC	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27281
...RRSKRC	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9708
...CSCSSL	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26722
...CSCSSL	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8560
...KECVYF	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8561
...ECVYFC	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8562
...VYFCHL	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26723
...FCHLDI	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26724
...FCHLDI	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8563
...CHLDII	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8217
...CHLDII	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8564
...HLDIIW	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8218
...LDIIWV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4714
...LDIIWV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8565
...LDIIWV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8588
...LDIIWV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15787
...LDIIWV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19923
...NTPEHV	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8566
...HVVPYG	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8413
...VVPYGL	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25633
...VVPYGL	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22453
...PYGLGS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8567
...PRSKRA	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27282
...PRSKRA	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9709
...DRENRC	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9710
...RKIRRS	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27283
...RKIRRS	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9711

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK7_HUMAN	52	SKRC.\|.CSCS	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,
FURIN_HUMAN	52	SKRC.\|.CSCS	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,
NEP_HUMAN	57	CSSL.\|.LMDK	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
ECE1_HUMAN	57	CSSL.\|.LMDK	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
ECE1_HUMAN	65	CVYF.\|.FCHL	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
ECE1_HUMAN	66	VYFC.\|.CHLD	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
NEP_HUMAN	68	FCHL.\|.LDII	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
NEP_HUMAN	70	HLDI.\|.IIWV	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
ECE1_HUMAN	70	HLDI.\|.IIWV	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
CBPA3_HUMAN	71	LDII.\|.IWVN	inferred from experiment	unknown	MEROPS	Rodewald HR	Schneider LA et al.:Molecular mechanism of mast cel... (M14.010)	17923505,
ECE1_HUMAN	71	LDII.\|.IWVN	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
CBPA3_HUMAN	72	DIIW.\|.WVNT	inferred from experiment	unknown	MEROPS	Rodewald HR	Schneider LA et al.:Molecular mechanism of mast cel... (M14.010)	17923505,
CATE_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Cook ND	Robinson PS et al.:Kinetic parameters for the gene... (A01.010)	1599425,
ECE1_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> EDN1_HUMAN @73
ECE2_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
KELL_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Redman C	Lee S et al.:Proteolytic processing of big e... (M13.090)	10438732,
MMEL1_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS		Merops MMEL1_HUMAN -> EDN1_HUMAN @73
ECE1_HUMAN	79	PEHV.\|.VVPY	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
CMA1_HUMAN	83	VPYG.\|.GLGS	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
MMP9_HUMAN	84	PYGL.\|.LGSP	inferred from experiment	unknown	MEROPS	Davidge ST	Fernandez-Patron C et al.:Vascular matrix metalloproteina... (M10.003)	10559137,
MMP2_HUMAN	84	PYGL.\|.LGSP	inferred from experiment	unknown	MEROPS	Davidge ST	Fernandez-Patron C et al.:Vascular matrix metalloproteina... (M10.003)	10559137,
ECE1_HUMAN	86	GLGS.\|.SPRS	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
PCSK7_HUMAN	92	SKRA.\|.ALEN	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,
FURIN_HUMAN	92	SKRA.\|.ALEN	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,
FURIN_HUMAN	108	ENRC.\|.CQCA	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,
PCSK7_HUMAN	168	IRRS.\|.SSEE	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,
FURIN_HUMAN	168	IRRS.\|.SSEE	inferred from experiment	unknown	MEROPS	Leduc R	Blais V et al.:Processing of proendothelin-1 b... (S08.071)	12135739,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)