TopFIND 4.0

Q16549: Proprotein convertase subtilisin/kexin type 7

General Information

Protein names
- Proprotein convertase subtilisin/kexin type 7
- 3.4.21.-
- Lymphoma proprotein convertase
- Prohormone convertase 7
- Proprotein convertase 7
- PC7
- Proprotein convertase 8
- PC8
- hPC8
- Subtilisin/kexin-like protease PC7
Gene names PCSK7
Organism Homo sapiens
Protease Family S08.077
Protease ID S08.077
Chromosome location
UniProt ID Q16549

3

N-termini

6

C-termini

0

Cleavages

145

Substrates

Sequence

        10         20         30         40         50         60 
MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG GPSWAVHLES 
        70         80         90        100        110        120 
LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ PAGHRPALEV EAIRQQVEAV 
       130        140        150        160        170        180 
LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY PQQWHLNNRR SPGRDINVTG VWERNVTGRG 
       190        200        210        220        230        240 
VTVVVVDDGV EHTIQDIAPN YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP 
       250        260        270        280        290        300 
NNSFCAVGVA YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP 
       310        320        330        340        350        360 
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT IGAVDEEGRM 
       370        380        390        400        410        420 
PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE GHTGTSAAAP LAAGMIALML 
       430        440        450        460        470        480 
QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT 
       490        500        510        520        530        540 
SVPYLASYVS PVLKENKAIP QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG 
       550        560        570        580        590        600 
SLELKLFCPS GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF 
       610        620        630        640        650        660 
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL KIPEEDGYTI 
       670        680        690        700        710        720 
TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR SGPCHWPHRS RKAKEEGTEL 
       730        740        750        760        770        780 
ESVPLCSSKD PDEVETESRG PPTTSDLLAP DLLEQGDWSL SQNKSALDCP HQHLDVPHGK 
   
EEQIC

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

3 N-termini - 6 C-termini - 0 Cleavages - 145 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates