TopFIND 4.0

P50281: Matrix metalloproteinase-14

General Information

Protein names
- Matrix metalloproteinase-14
- MMP-14
- 3.4.24.80
- MMP-X1
- Membrane-type matrix metalloproteinase 1
- MT-MMP 1
- MTMMP1
- Membrane-type-1 matrix metalloproteinase
- MT1-MMP
- MT1MMP

Gene names MMP14
Organism Homo sapiens
Protease Family M10.014
Protease ID M10.014
Chromosome location
UniProt ID P50281

12

N-termini

13

C-termini

20

Cleavages

221

Substrates

Sequence

        10         20         30         40         50         60 
MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 
        70         80         90        100        110        120 
LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ 
       130        140        150        160        170        180 
HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF 
       190        200        210        220        230        240 
FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE 
       250        260        270        280        290        300 
LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT 
       310        320        330        340        350        360 
SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 
       370        380        390        400        410        420 
WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 
       430        440        450        460        470        480 
WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 
       490        500        510        520        530        540 
NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA 
       550        560        570        580    
AVVLPVLLLL LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

12 N-termini - 13 C-termini - 20 Cleavages - 221 Substrates

N-termini

C-termini

Cleavages

Substrates