P02649: Apolipoprotein E

General Information

Protein names	- Apolipoprotein E - Apo-E
Gene names	APOE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02649

23 N-termini

13 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKVLWAALLV TFLAGCQAKV EQAVETEPEP ELRQQTEWQS GQRWELALGR FWDYLRWVQT
        70         80         90        100        110        120
LSEQVQEELL SSQVTQELRA LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA
       130        140        150        160        170        180
RLGADMEDVC GRLVQYRGEV QAMLGQSTEE LRVRLASHLR KLRKRLLRDA DDLQKRLAVY
       190        200        210        220        230        240
QAGAREGAER GLSAIRERLG PLVEQGRVRA ATVGSLAGQP LQERAQAWGE RLRARMEEMG
       250        260        270        280        290        300
SRTRDRLDEV KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK
       310
VQAAVGTSAA PVPSDNH

Isoforms

Sequence View

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Directness:

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

23 N-termini - 13 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P02649-19-unknown	KVEQAV...	19	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02649-19-unknown	KVEQAV...	19		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-19-	KVEQAV...	19		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P02649-19-	KVEQAV...	19		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P02649-19-	KVEQAV...	19		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P02649-23-unknown	AVETEP...	23		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-86-unknown	MKELKA...	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21446
P02649-94-unknown	SELEEQ...	94	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21447
P02649-111-unknown	LSKELQ...	111		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-178-unknown	AVYQAG...	178		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-179-unknown	VYQAGA...	179		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-195-unknown	IRERLG...	195	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21448
P02649-199-unknown	LGPLVE...	199		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-202-unknown	LVEQGR...	202	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21449
P02649-210-unknown	AATVGS...	210		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-211-unknown	ATVGSL...	211		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-212-unknown	TVGSLA...	212		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-214-unknown	GSLAGQ...	214		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-221-unknown	LQERAQ...	221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21450
P02649-234-unknown	ARMEEM...	234		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-236-unknown	MEEMGS...	236		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-247-unknown	LDEVKE...	247	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21451
P02649-256-unknown	EVRAKL...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21452
P02649-268-unknown	IRLQAE...	268	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21453
P02649-281-unknown	SWFEPL...	281		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02649-297-unknown	LVEKVQ...	297	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21454

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LMDETM	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21446
...LKAYKS	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21447
...RGLSAI	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21448
...ERLGPL	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21449
...TVGSLA	216	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413135
...SLAGQP	219	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410423
...LAGQPL	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21450
...MGSRTR	243	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413653
...RTRDRL	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21451
...KEQVAE	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21452
...EQAQQI	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21453
...RQWAGL	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21454
...PSDNH	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP14_HUMAN	85	DETM.\|.MKEL	inferred from experiment	unknown	MEROPS	Sato H	Aoki T et al.:Cleavage of apolipoprotein E by... (M10.014)	15713888,
MMP14_HUMAN	93	AYKS.\|.SELE	inferred from experiment	unknown	MEROPS	Sato H	Aoki T et al.:Cleavage of apolipoprotein E by... (M10.014)	15713888,
MMP14_HUMAN	194	LSAI.\|.IRER	inferred from experiment	unknown	MEROPS	Lee ST	Park JH et al.:Cleavage and functional loss of... (M10.014)	18655030,
MMP14_HUMAN	201	LGPL.\|.LVEQ	inferred from experiment	unknown	MEROPS	Lee ST	Park JH et al.:Cleavage and functional loss of... (M10.014)	18655030,
MMP14_HUMAN	220	GQPL.\|.LQER	inferred from experiment	unknown	MEROPS	Lee ST	Park JH et al.:Cleavage and functional loss of... (M10.014)	18655030,
MMP14_HUMAN	246	RDRL.\|.LDEV	inferred from experiment	unknown	MEROPS	Sato H	Aoki T et al.:Cleavage of apolipoprotein E by... (M10.014)	15713888,
MMP14_HUMAN	255	QVAE.\|.EVRA	inferred from experiment	unknown	MEROPS	Sato H	Aoki T et al.:Cleavage of apolipoprotein E by... (M10.014)	15713888,
MMP14_HUMAN	267	AQQI.\|.IRLQ	inferred from experiment	unknown	MEROPS	Lee ST	Park JH et al.:Cleavage and functional loss of... (M10.014)	18655030,
MMP14_HUMAN	296	WAGL.\|.LVEK	inferred from experiment	unknown	MEROPS	Sato H	Aoki T et al.:Cleavage of apolipoprotein E by... (M10.014)	15713888,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)