P10145: Interleukin-8

General Information

Protein names	- Interleukin-8 - IL-8 - C-X-C motif chemokine 8 - Chemokine (C-X-C motif) ligand 8 - Emoctakin - Granulocyte chemotactic protein 1 - GCP-1 - Monocyte-derived neutrophil chemotactic factor - MDNCF - Monocyte-derived neutrophil-activating peptide - MONAP - Neutrophil-activating protein 1 - NAP-1 - Protein 3-10C - T-cell chemotactic factor - MDNCF-a - GCP/IL-8 protein IV - IL8/NAP1 form I - Interleukin-8 - (Ala-IL-8)77 - GCP/IL-8 protein II - IL-8(1-77) - IL8/NAP1 form II - MDNCF-b - IL-8(5-77) - IL-8(6-77) - (Ser-IL-8)72 - GCP/IL-8 protein I - IL8/NAP1 form III - Lymphocyte-derived neutrophil-activating factor - LYNAP - MDNCF-c - Neutrophil-activating factor - NAF - IL-8(7-77) - GCP/IL-8 protein V - IL8/NAP1 form IV - IL-8(8-77) - GCP/IL-8 protein VI - IL8/NAP1 form V - IL-8(9-77) - GCP/IL-8 protein III - IL8/NAP1 form VI
Gene names	CXCL8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10145

8 N-termini

3 C-termini

6 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH
70 80 90
CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS

Isoforms

- Isoform 2 of Interleukin-8

Sequence View

10 20 30 40 50 60
MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH
70 80 90
CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS

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Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P10145-1-unknown	MTSKLA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77808
P10145-21-unknown	EGAVLP...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-21-unknown	EGAVLP...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112718
P10145-23-unknown	AVLPRS...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-23-unknown	AVLPRS...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113281
P10145-27-unknown	RSAKEL...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-27-unknown	RSAKEL...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114236
P10145-28-unknown	SAKELR...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-28-unknown	SAKELR...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21523
P10145-28-unknown	SAKELR...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21380
P10145-28-unknown	SAKELR...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5541
P10145-28-unknown	SAKELR...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25069
P10145-28-unknown	SAKELR...	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114403
P10145-29-unknown	AKELRC...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-29-unknown	AKELRC...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25670
P10145-29-unknown	AKELRC...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21738
P10145-29-unknown	AKELRC...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114529
P10145-30-unknown	KELRCQ...	30	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-30-unknown	KELRCQ...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114686
P10145-31-unknown	ELRCQC...	31	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10145-31-unknown	ELRCQC...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114860

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AVLPRS	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21523
...AVLPRS	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21380
...AVLPRS	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5541
...AVLPRS	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25069
...AVLPRS	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120328
...VLPRSA	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25670
...VLPRSA	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21738
...VLPRSA	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120422
...RAENS	99	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP14_HUMAN	27	LPRS.\|.SAKE	inferred from experiment	unknown	MEROPS	Overall CM	Tam EM et al.:Membrane protease proteomics: I... (M10.014)	15118097,
MMP13_HUMAN	27	LPRS.\|.SAKE	inferred from experiment	unknown	MEROPS	Overall CM	Tester AM et al.:LPS responsiveness and neutroph... (M10.013)	17375198,
CATL1_HUMAN	27	LPRS.\|.SAKE	inferred from experiment	unknown	MEROPS	Sano E	Ohashi K et al.:Identification of interleukin-8... (C01.032)	12818188,
MMP8_HUMAN	27	LPRS.\|.SAKE	inferred from experiment	unknown	MEROPS	Overall CM	Tester AM et al.:LPS responsiveness and neutroph... (M10.013)	17375198,
MMP9_HUMAN	28	PRSA.\|.AKEL	inferred from experiment	unknown	MEROPS	Opdenakker G	Van den Steen PE et al.:Carboxyterminal cleavage of the... (M10.004)	14550288,
MMP1_HUMAN	28	PRSA.\|.AKEL	inferred from experiment	unknown	MEROPS	Overall CM	Tester AM et al.:LPS responsiveness and neutroph... (M10.013)	17375198,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)