P02679: Fibrinogen gamma chain

General Information

Protein names	- Fibrinogen gamma chain
Gene names	FGG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02679

13 N-termini

12 C-termini

15 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSWSLHPRNL ILYFYALLFL SSTCVAYVAT RDNCCILDER FGSYCPTTCG IADFLSTYQT
        70         80         90        100        110        120
KVDKDLQSLE DILHQVENKT SEVKQLIKAI QLTYNPDESS KPNMIDAATL KSRKMLEEIM
       130        140        150        160        170        180
KYEASILTHD SSIRYLQEIY NSNNQKIVNL KEKVAQLEAQ CQEPCKDTVQ IHDITGKDCQ
       190        200        210        220        230        240
DIANKGAKQS GLYFIKPLKA NQQFLVYCEI DGSGNGWTVF QKRLDGSVDF KKNWIQYKEG
       250        260        270        280        290        300
FGHLSPTGTT EFWLGNEKIH LISTQSAIPY ALRVELEDWN GRTSTADYAM FKVGPEADKY
       310        320        330        340        350        360
RLTYAYFAGG DAGDAFDGFD FGDDPSDKFF TSHNGMQFST WDNDNDKFEG NCAEQDGSGW
       370        380        390        400        410        420
WMNKCHAGHL NGVYYQGGTY SKASTPNGYD NGIIWATWKT RWYSMKKTTM KIIPFNRLTI
       430        440        450
GEGQQHHLGG AKQVRPEHPA ETEYDSLYPE DDL

Isoforms

- Isoform Gamma-A of Fibrinogen gamma chain

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 12 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P02679-1-unknown	MSWSLH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75188
P02679-27-unknown	YVATRD...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02679-27-unknown	YVATRD...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114309
P02679-88-unknown	KAIQLT...	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8279
P02679-88-unknown	KAIQLT...	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8323
P02679-88-unknown	KAIQLT...	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141704
P02679-89-unknown	AIQLTY...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27465
P02679-89-unknown	AIQLTY...	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141761
P02679-92-unknown	LTYNPD...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21471
P02679-92-unknown	LTYNPD...	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141965
P02679-104-unknown	MIDAAT...	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21882
P02679-104-unknown	MIDAAT...	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142596
P02679-105-unknown	IDAATL...	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21473
P02679-105-unknown	IDAATL...	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142661
P02679-110-unknown	LKSRKM...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23726
P02679-110-unknown	LKSRKM...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23996
P02679-110-unknown	LKSRKM...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21475
P02679-110-unknown	LKSRKM...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142950
P02679-111-unknown	KSRKML...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8281
P02679-111-unknown	KSRKML...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8325
P02679-111-unknown	KSRKML...	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142991
P02679-112-unknown	SRKMLE...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27467
P02679-112-unknown	SRKMLE...	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143051
P02679-383-unknown	ASTPNG...	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27469
P02679-383-unknown	ASTPNG...	383	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151695
P02679-400-unknown	TRWYSM...	400	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27471
P02679-400-unknown	TRWYSM...	400	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152002
P02679-431-unknown	AKQVRP...	431	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23728

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VKQLIK	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8279
...VKQLIK	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8323
...VKQLIK	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124886
...KQLIKA	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27465
...KQLIKA	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124944
...IKAIQL	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21471
...IKAIQL	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125146
...SSKPNM	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21882
...SSKPNM	103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125791
...SKPNMI	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21473
...SKPNMI	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125861
...IDAATL	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23726
...IDAATL	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23996
...IDAATL	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21475
...IDAATL	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126160
...DAATLK	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8281
...DAATLK	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8325
...DAATLK	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126199
...AATLKS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27467
...AATLKS	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126271
...GTYSKA	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27469
...GTYSKA	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135098
...WATWKT	399	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27471
...WATWKT	399	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135411
...HHLGGA	430	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23728
...PEDDL	453	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CBPB2_HUMAN	87	QLIK.\|.KAIQ	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
CBPN_HUMAN	87	QLIK.\|.KAIQ	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
PLMN_HUMAN	88	LIKA.\|.AIQL	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
MMP14_HUMAN	91	AIQL.\|.LTYN	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP26_HUMAN	103	KPNM.\|.MIDA	inferred from experiment	unknown	MEROPS	Sang QX	Park HI et al.:Peptide substrate specificities... (M10.029)	12119297,
MMP14_HUMAN	104	PNMI.\|.IDAA	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP3_HUMAN	109	AATL.\|.LKSR	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP7_HUMAN	109	AATL.\|.LKSR	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP14_HUMAN	109	AATL.\|.LKSR	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
CBPB2_HUMAN	110	ATLK.\|.KSRK	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
CBPN_HUMAN	110	ATLK.\|.KSRK	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
PLMN_HUMAN	111	TLKS.\|.SRKM	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	382	YSKA.\|.ASTP	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	399	TWKT.\|.TRWY	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
MMP3_HUMAN	430	LGGA.\|.AKQV	inferred from experiment	unknown	MEROPS	Nagase H	Bini A et al.:Degradation of cross-linked fib... (M10.005)	8855941,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)