Q15726: Metastasis-suppressor KiSS-1

General Information

Protein names	- Metastasis-suppressor KiSS-1 - Kisspeptin-1 - Metastin - Kisspeptin-54 - Kisspeptin-14 - Kisspeptin-13 - Kisspeptin-10
Gene names	KISS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15726

4 N-termini

4 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA
        70         80         90        100        110        120
TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR
       130
FGKREAAPGN HGRSAGRG

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q15726-20-unknown	EPLEKV...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q15726-113-unknown	NWNSFG...	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC255
Q15726-114-unknown	WNSFGL...	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC256
Q15726-119-unknown	LRFGKR...	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21824
Q15726-119-unknown	LRFGKR...	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26463
Q15726-119-unknown	LRFGKR...	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23398
Q15726-119-unknown	LRFGKR...	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21622
Q15726-119-unknown	LRFGKR...	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21670

Name

Sequence

Position

Modification

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMID)

Q15726-20-unknown

EPLEKV...

inferred from electronic annotation

electronic annotation

UniProtKB

inferred from uniprot

Q15726-113-unknown

NWNSFG...

113

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC255

Q15726-114-unknown

WNSFGL...

114

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC256

Q15726-119-unknown

LRFGKR...

119

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC21824

Q15726-119-unknown

LRFGKR...

119

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26463

Q15726-119-unknown

LRFGKR...

119

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC23398

Q15726-119-unknown

LRFGKR...

119

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC21622

Q15726-119-unknown

LRFGKR...

119

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC21670

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLPNYN	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC255
...LPNYNW	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC256
...WNSFGL	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21824
...WNSFGL	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26463
...WNSFGL	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23398
...WNSFGL	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21622
...WNSFGL	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21670
...SAGRG	138	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
AMPQ_HUMAN	112	PNYN.\|.NWNS	inferred from experiment	unknown	MEROPS	Tsujimoto M	Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)	17525158,
AMPQ_HUMAN	113	NYNW.\|.WNSF	inferred from experiment	unknown	MEROPS	Tsujimoto M	Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)	17525158,
MMP24_HUMAN	118	SFGL.\|.LRFG	inferred from experiment	unknown	MEROPS	Sato H	Takino T et al.:Cleavage of metastasis suppress... (M10.014)	12879005,
MMP9_HUMAN	118	SFGL.\|.LRFG	inferred from experiment	unknown	MEROPS	Sato H	Takino T et al.:Cleavage of metastasis suppress... (M10.014)	12879005,
MMP2_HUMAN	118	SFGL.\|.LRFG	inferred from experiment	unknown	MEROPS	Sato H	Takino T et al.:Cleavage of metastasis suppress... (M10.014)	12879005,
MMP14_HUMAN	118	SFGL.\|.LRFG	inferred from experiment	unknown	MEROPS	Sato H	Takino T et al.:Cleavage of metastasis suppress... (M10.014)	12879005,
MMP16_HUMAN	118	SFGL.\|.LRFG	inferred from experiment	unknown	MEROPS	Sato H	Takino T et al.:Cleavage of metastasis suppress... (M10.014)	12879005,

Protease

Position

Sequence

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMIDs)

AMPQ_HUMAN

112

PNYN.|.NWNS

inferred from experiment

unknown

MEROPS

Tsujimoto M

Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)

17525158,

AMPQ_HUMAN

113

NYNW.|.WNSF

inferred from experiment

unknown

MEROPS

Tsujimoto M

Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)

17525158,

MMP24_HUMAN

118

SFGL.|.LRFG

inferred from experiment

unknown

MEROPS

Sato H

Takino T et al.:Cleavage of metastasis suppress... (M10.014)

12879005,

MMP9_HUMAN

118

SFGL.|.LRFG

inferred from experiment

unknown

MEROPS

Sato H

Takino T et al.:Cleavage of metastasis suppress... (M10.014)

12879005,

MMP2_HUMAN

118

SFGL.|.LRFG

inferred from experiment

unknown

MEROPS

Sato H

Takino T et al.:Cleavage of metastasis suppress... (M10.014)

12879005,

MMP14_HUMAN

118

SFGL.|.LRFG

inferred from experiment

unknown

MEROPS

Sato H

Takino T et al.:Cleavage of metastasis suppress... (M10.014)

12879005,

MMP16_HUMAN

118

SFGL.|.LRFG

inferred from experiment

unknown

MEROPS

Sato H

Takino T et al.:Cleavage of metastasis suppress... (M10.014)

12879005,

TopFIND

Q15726: Metastasis-suppressor KiSS-1

General Information

4

N-termini

4

C-termini

7

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 7 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates