Q6Q4G3: Aminopeptidase Q {ECO:0000305}
Protein names | - Aminopeptidase Q {ECO:0000305} - AP-Q {ECO:0000305} - APQ {ECO:0000303|PubMed:17525158} - 3.4.11.- {ECO:0000269|PubMed:17525158} - CHL2 antigen {ECO:0000303|PubMed:14706636} - Laeverin {ECO:0000303|PubMed:14706636} |
---|---|
Gene names | AQPEP |
Organism | Homo sapiens |
Protease Family | M01.026 |
Protease ID | M01.026 |
Chromosome location | |
UniProt ID | Q6Q4G3 |
3
N-termini
1
C-termini
0
Cleavages
13
Substrates
Sequence
10 20 30 40 50 60
MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG LRDLEAESSP
70 80 90 100 110 120
PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP WLVPLHYDLE LWPQLRPDEL
130 140 150 160 170 180
PAGSLPFTGR VNITVRCTVA TSRLLLHSLF QDCERAEVRG PLSPGTGNAT VGRVPVDDVW
190 200 210 220 230 240
FALDTEYMVL ELSEPLKPGS SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE
250 260 270 280 290 300
PTFARYVFPC FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT
310 320 330 340 350 360
PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP IFSFLEDLFN
370 380 390 400 410 420
ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD QLTEKKTLIS YVVSHEIGHQ
430 440 450 460 470 480
WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN YFNPKLPRNE IFFSNILHNI LREDHALVTR
490 500 510 520 530 540
AVAMKVENFK TSEIQELFDI FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ
550 560 570 580 590 600
DDLWRHFQMA IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN
610 620 630 640 650 660
RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL NLNMTGYYRV
670 680 690 700 710 720
NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN YIEIETALEL TKYLAEEDEI
730 740 750 760 770 780
IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR YLLKRLNLIW NIYSTIIREN VLALQDDYLA
790 800 810 820 830 840
LISLEKLFVT ACWLGLEDCL QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD
850 860 870 880 890 900
ILLNTYTNTT NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV
910 920 930 940 950 960
GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS NMLEEHQRIR
970 980 990
VHANLQTIKN ENLKNKKLSA RIAAWLRRNT
Isoforms
- Isoform 2 of Aminopeptidase Q - Isoform 3 of Aminopeptidase Q - Isoform 4 of Aminopeptidase QSequence View
10 20 30 40 50 60
MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG LRDLEAESSP
70 80 90 100 110 120
PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP WLVPLHYDLE LWPQLRPDEL
130 140 150 160 170 180
PAGSLPFTGR VNITVRCTVA TSRLLLHSLF QDCERAEVRG PLSPGTGNAT VGRVPVDDVW
190 200 210 220 230 240
FALDTEYMVL ELSEPLKPGS SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE
250 260 270 280 290 300
PTFARYVFPC FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT
310 320 330 340 350 360
PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP IFSFLEDLFN
370 380 390 400 410 420
ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD QLTEKKTLIS YVVSHEIGHQ
430 440 450 460 470 480
WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN YFNPKLPRNE IFFSNILHNI LREDHALVTR
490 500 510 520 530 540
AVAMKVENFK TSEIQELFDI FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ
550 560 570 580 590 600
DDLWRHFQMA IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN
610 620 630 640 650 660
RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL NLNMTGYYRV
670 680 690 700 710 720
NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN YIEIETALEL TKYLAEEDEI
730 740 750 760 770 780
IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR YLLKRLNLIW NIYSTIIREN VLALQDDYLA
790 800 810 820 830 840
LISLEKLFVT ACWLGLEDCL QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD
850 860 870 880 890 900
ILLNTYTNTT NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV
910 920 930 940 950 960
GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS NMLEEHQRIR
970 980 990
VHANLQTIKN ENLKNKKLSA RIAAWLRRNT
10 20 30 40 50 60
MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG LRDLEAESSP
70 80 90 100 110 120
PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP WLVPLHYDLE LWPQLRPDEL
130 140 150 160 170 180
PAGSLPFTGR VNITVRCTVA TSRLLLHSLF QDCERAEVRG PLSPGTGNAT VGRVPVDDVW
190 200 210 220 230 240
FALDTEYMVL ELSEPLKPGS SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE
250 260 270 280 290 300
PTFARYVFPC FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT
310 320 330 340 350 360
PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP IFSFLEDLFN
370 380 390 400 410 420
ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD QLTEKKTLIS YVVSHEIGHQ
430 440 450 460 470 480
WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN YFNPKLPRNE IFFSNILHNI LREDHALVTR
490 500 510 520 530 540
AVAMKVENFK TSEIQELFDI FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ
550 560 570 580 590 600
DDLWRHFQMA IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN
610 620 630 640 650 660
RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL NLNMTGYYRV
670 680 690 700 710 720
NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN YIEIETALEL TKYLAEEDEI
730 740 750 760 770 780
IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR YLLKRLNLIW NIYSTIIREN VLALQDDYLA
790 800 810 820 830 840
LISLEKLFVT ACWLGLEDCL QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD
850 860 870 880 890 900
ILLNTYTNTT NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV
910 920 930 940 950 960
GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS NMLEEHQRIR
970 980 990
VHANLQTIKN ENLKNKKLSA RIAAWLRRNT
10 20 30 40 50 60
MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG LRDLEAESSP
70 80 90 100 110 120
PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP WLVPLHYDLE LWPQLRPDEL
130 140 150 160 170 180
PAGSLPFTGR VNITVRCTVA TSRLLLHSLF QDCERAEVRG PLSPGTGNAT VGRVPVDDVW
190 200 210 220 230 240
FALDTEYMVL ELSEPLKPGS SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE
250 260 270 280 290 300
PTFARYVFPC FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT
310 320 330 340 350 360
PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP IFSFLEDLFN
370 380 390 400 410 420
ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD QLTEKKTLIS YVVSHEIGHQ
430 440 450 460 470 480
WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN YFNPKLPRNE IFFSNILHNI LREDHALVTR
490 500 510 520 530 540
AVAMKVENFK TSEIQELFDI FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ
550 560 570 580 590 600
DDLWRHFQMA IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN
610 620 630 640 650 660
RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL NLNMTGYYRV
670 680 690 700 710 720
NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN YIEIETALEL TKYLAEEDEI
730 740 750 760 770 780
IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR YLLKRLNLIW NIYSTIIREN VLALQDDYLA
790 800 810 820 830 840
LISLEKLFVT ACWLGLEDCL QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD
850 860 870 880 890 900
ILLNTYTNTT NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV
910 920 930 940 950 960
GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS NMLEEHQRIR
970 980 990
VHANLQTIKN ENLKNKKLSA RIAAWLRRNT
Protein Neighborhood
Domains & Features
3 N-termini - 1 C-termini - 0 Cleavages - 13 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6Q4G3-1-unknown | MGPPSS... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66830 | |||
Q6Q4G3-2-unknown | GPPSSS... | 2 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6Q4G3-2-unknown | GPPSSS... | 2 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110429 | |||
Q6Q4G3-484-unknown | MKVENF... | 484 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66831 | |||
Q6Q4G3-484-unknown | MKVENF... | 484 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66832 | |||
Q6Q4G3-484-unknown | MKVENF... | 484 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt96661 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LRRNT | 990 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
ANGT_HUMAN | 35 | GDRV.|.VYIH | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
TKN4-Isoform5_HUMAN | 76 | RRKK.|.KAYQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC257 | ||
TKN4-Isoform5_HUMAN | 77 | RKKA.|.AYQL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC259 | ||
TKN4_HUMAN | 82 | RRKK.|.KAYQ | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
TKN4_HUMAN | 83 | RKKA.|.AYQL | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
KISS1_HUMAN | 112 | PNYN.|.NWNS | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
KISS1_HUMAN | 113 | NYNW.|.WNSF | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
PDYN_HUMAN | 207 | KRYG.|.GGFL | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
PDYN_HUMAN | 208 | RYGG.|.GFLR | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
PDYN_HUMAN | 209 | YGGF.|.FLRR | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
KNG1-Isoform3_HUMAN | 344 | LMKR.|.RPPG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC249 | ||
KNG1_HUMAN | 380 | LMKR.|.RPPG | inferred from experiment | unknown | MEROPS | Tsujimoto M | Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026) | 17525158, |
KNG1-Isoform2_HUMAN | 380 | LMKR.|.RPPG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC249 |