P01213: Proenkephalin-B

General Information

Protein names	- Proenkephalin-B - Beta-neoendorphin-dynorphin - Preprodynorphin - Alpha-neoendorphin - Beta-neoendorphin - Big dynorphin - Big Dyn - Dynorphin A(1-17) - Dyn-A17 - Dynorphin A - Dynorphin A(1-13) - Dynorphin A(1-8) - Leu-enkephalin - Rimorphin - Dynorphin B - Dyn-B - Dynorphin B(1-13) - Leumorphin - Dynorphin B-29
Gene names	PDYN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01213

25 N-termini

25 C-termini

47 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAWQGLVLAA CLLMFPSTTA DCLSRCSLCA VKTQDGPKPI NPLICSLQCQ AALLPSEEWE
        70         80         90        100        110        120
RCQSFLSFFT PSTLGLNDKE DLGSKSVGEG PYSELAKLSG SFLKELEKSK FLPSISTKEN
       130        140        150        160        170        180
TLSKSLEEKL RGLSDGFREG AESELMRDAQ LNDGAMETGT LYLAEEDPKE QVKRYGGFLR
       190        200        210        220        230        240
KYPKRSSEVA GEGDGDSMGH EDLYKRYGGF LRRIRPKLKW DNQKRYGGFL RRQFKVVTRS
       250
QEDPNAYSGE LFDA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

25 N-termini - 25 C-termini - 47 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01213-175-unknown	YGGFLR...	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC225
P01213-176-unknown	GGFLRK...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16711
P01213-176-unknown	GGFLRK...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16772
P01213-176-unknown	GGFLRK...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27811
P01213-176-unknown	GGFLRK...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC246
P01213-176-unknown	GGFLRK...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27643
P01213-177-unknown	GFLRKY...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8473
P01213-177-unknown	GFLRKY...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5348
P01213-178-unknown	FLRKYP...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3334
P01213-178-unknown	FLRKYP...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26698
P01213-178-unknown	FLRKYP...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31894
P01213-178-unknown	FLRKYP...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19902
P01213-179-unknown	LRKYPK...	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8262
P01213-180-unknown	RKYPKR...	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8314
P01213-180-unknown	RKYPKR...	180	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01213-180-unknown	RKYPKR...	180	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P01213-208-unknown	GGFLRR...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC252
P01213-208-unknown	GGFLRR...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27644
P01213-209-unknown	GFLRRI...	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC253
P01213-210-unknown	FLRRIR...	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26699
P01213-210-unknown	FLRRIR...	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31895
P01213-210-unknown	FLRRIR...	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31685
P01213-210-unknown	FLRRIR...	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC254
P01213-211-unknown	LRRIRP...	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26700
P01213-212-unknown	RRIRPK...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17
P01213-212-unknown	RRIRPK...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4966
P01213-212-unknown	RRIRPK...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8295
P01213-212-unknown	RRIRPK...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26769
P01213-212-unknown	RRIRPK...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31686
P01213-212-unknown	RRIRPK...	212	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01213-212-unknown	RRIRPK...	212	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P01213-213-unknown	RIRPKL...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3335
P01213-213-unknown	RIRPKL...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC868
P01213-213-unknown	RIRPKL...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8296
P01213-214-unknown	IRPKLK...	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26701
P01213-214-unknown	IRPKLK...	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27645
P01213-217-unknown	KLKWDN...	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27646
P01213-218-unknown	LKWDNQ...	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26770
P01213-219-unknown	KWDNQK...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6
P01213-219-unknown	KWDNQK...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26771
P01213-223-unknown	QKRYGG...	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8263
P01213-227-unknown	GGFLRR...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27647
P01213-230-unknown	LRRQFK...	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8222
P01213-231-unknown	RRQFKV...	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31687
P01213-234-unknown	FKVVTR...	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8586
P01213-235-unknown	KVVTRS...	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27648
P01213-235-unknown	KVVTRS...	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31688
P01213-236-unknown	VVTRSQ...	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27649
P01213-236-unknown	VVTRSQ...	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8587
P01213-239-unknown	RSQEDP...	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27650
P01213-240-unknown	SQEDPN...	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27651

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EQVKRY	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC225
...QVKRYG	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16711
...QVKRYG	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16772
...QVKRYG	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27811
...QVKRYG	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC246
...QVKRYG	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27643
...VKRYGG	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8473
...VKRYGG	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5348
...KRYGGF	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3334
...KRYGGF	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26698
...KRYGGF	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31894
...KRYGGF	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19902
...RYGGFL	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8262
...YGGFLR	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8314
...LYKRYG	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC252
...LYKRYG	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27644
...YKRYGG	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC253
...KRYGGF	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26699
...KRYGGF	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31895
...KRYGGF	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31685
...KRYGGF	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC254
...RYGGFL	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26700
...YGGFLR	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17
...YGGFLR	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4966
...YGGFLR	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8295
...YGGFLR	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26769
...YGGFLR	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31686
...GGFLRR	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3335
...GGFLRR	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC868
...GGFLRR	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8296
...GFLRRI	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26701
...GFLRRI	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27645
...RRIRPK	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27646
...RIRPKL	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26770
...IRPKLK	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6
...IRPKLK	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26771
...LKWDNQ	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8263
...NQKRYG	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27647
...RYGGFL	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8222
...YGGFLR	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31687
...FLRRQF	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8586
...LRRQFK	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27648
...LRRQFK	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31688
...RRQFKV	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27649
...RRQFKV	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8587
...FKVVTR	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27650
...KVVTRS	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27651

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
AMPB_HUMAN	174	VKRY.\|.YGGF	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> PDYN_HUMAN @174
LCAP_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Albiston AL	Ye S et al.:Identification of modulating re... (M01.011)	18523486,
LKHA4_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Fitzpatrick FA	Griffin KJ et al.:Opioid peptides are substrates ... (M01.004)	1410529,
PSA_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS		Merops PSA_HUMAN -> PDYN_HUMAN @175
AMPN_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS		Merops AMPN_HUMAN -> PDYN_HUMAN @175
PREP_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
DPP3_HUMAN	176	RYGG.\|.GFLR	inferred from experiment	unknown	MEROPS		Merops DPP3_HUMAN -> PDYN_HUMAN @176
CATL1_HUMAN	176	RYGG.\|.GFLR	inferred from experiment	unknown	MEROPS	Berg MJ	Marks N et al.:Diversity of rat brain cysteine... (C01.032)	3265047,
CATB_HUMAN	177	YGGF.\|.FLRK	inferred from experiment	unknown	MEROPS	Tang J	Takahashi T et al.:Porcine spleen cathepsin B is a... (C01.060)	3522589,
NEP_HUMAN	177	YGGF.\|.FLRK	inferred from experiment	unknown	MEROPS	Turner AJ	Matsas R et al.:The metabolism of neuropeptides... (M13.001)	6149747,
TPP1_HUMAN	177	YGGF.\|.FLRK	inferred from experiment	unknown	MEROPS	Ohkubo I	Du PG et al.:Rat tripeptidyl peptidase I: mo... (S53.003)	11843185,
MMEL1_HUMAN	177	YGGF.\|.FLRK	inferred from experiment	unknown	MEROPS		Merops MMEL1_HUMAN -> PDYN_HUMAN @177
CBPA6_HUMAN	178	GGFL.\|.LRKY	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Characterization of carboxypept... (M14.018)	18178555,
CBPM_HUMAN	179	GFLR.\|.RKYP	inferred from experiment	unknown	MEROPS		Merops CBPM_HUMAN -> PDYN_HUMAN @179
AMPQ_HUMAN	207	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Tsujimoto M	Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)	17525158,
PREP_HUMAN	207	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
AMPQ_HUMAN	208	RYGG.\|.GFLR	inferred from experiment	unknown	MEROPS	Tsujimoto M	Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)	17525158,
NEP_HUMAN	209	YGGF.\|.FLRR	inferred from experiment	unknown	MEROPS	Turner AJ	Matsas R et al.:The metabolism of neuropeptides... (M13.001)	6149747,
TPP1_HUMAN	209	YGGF.\|.FLRR	inferred from experiment	unknown	MEROPS	Oda K	Oyama H et al.:Catalytic residues and substrat... (S53.003)	16091586,
THOP1_HUMAN	209	YGGF.\|.FLRR	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Human thimet oligopeptidase.... (M03.001)	8373360,
AMPQ_HUMAN	209	YGGF.\|.FLRR	inferred from experiment	unknown	MEROPS	Tsujimoto M	Maruyama M et al.:Laeverin/aminopeptidase Q, a no... (M01.026)	17525158,
NEP_HUMAN	210	GGFL.\|.LRRI	inferred from experiment	unknown	MEROPS	Turner AJ	Matsas R et al.:The metabolism of neuropeptides... (M13.001)	6149747,
ACE_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Coates D	Isaac RE et al.:Cleavage of arginyl-arginine an... (M02.001)	9371719,
CATH_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Popovic T	Brguljan PM et al.:Human brain cathepsin H as a ne... (C01.040)	15127951,
CBPE_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Tarentino AL	Grimwood BG et al.:Carboxypeptidase H. A regulator... (M14.005)	2549070,
NEUL_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Barrett AJ	Serizawa A et al.:Characterization of a mitochond... (M03.002)	7836437,
THOP1_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Human thimet oligopeptidase.... (M03.001)	8373360,
CATB_HUMAN	212	FLRR.\|.RIRP	inferred from experiment	unknown	MEROPS	Tang J	Takahashi T et al.:Porcine spleen cathepsin B is a... (C01.060)	3522589,
CAN2_HUMAN	212	FLRR.\|.RIRP	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
CBPE_HUMAN	212	FLRR.\|.RIRP	inferred from experiment	unknown	MEROPS	Tarentino AL	Grimwood BG et al.:Carboxypeptidase H. A regulator... (M14.005)	2549070,
NEP_HUMAN	213	LRRI.\|.IRPK	inferred from experiment	unknown	MEROPS	Turner AJ	Matsas R et al.:The metabolism of neuropeptides... (M13.001)	6149747,
PREP_HUMAN	213	LRRI.\|.IRPK	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	216	IRPK.\|.KLKW	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
NEUL_HUMAN	217	RPKL.\|.LKWD	inferred from experiment	unknown	MEROPS	Barrett AJ	Serizawa A et al.:Characterization of a mitochond... (M03.002)	7836437,
ACE2_HUMAN	218	PKLK.\|.KWDN	inferred from experiment	unknown	MEROPS	Tummino P	Vickers C et al.:Hydrolysis of biological peptid... (M02.006)	11815627,
NEUL_HUMAN	218	PKLK.\|.KWDN	inferred from experiment	unknown	MEROPS	Barrett AJ	Serizawa A et al.:Characterization of a mitochond... (M03.002)	7836437,
CBPA6_HUMAN	222	WDNQ.\|.QKRY	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Substrate specificity of human ... (M14.018)	20855895,
PREP_HUMAN	226	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
CBPA4_HUMAN	229	GGFL.\|.LRRQ	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
THOP1_HUMAN	230	GFLR.\|.RRQF	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Human thimet oligopeptidase.... (M03.001)	8373360,
ECE2_HUMAN	233	RRQF.\|.FKVV	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
PREP_HUMAN	234	RQFK.\|.KVVT	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
THOP1_HUMAN	234	RQFK.\|.KVVT	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Human thimet oligopeptidase.... (M03.001)	8373360,
PREP_HUMAN	235	QFKV.\|.VVTR	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
ECE2_HUMAN	235	QFKV.\|.VVTR	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Characterization of endothelin-... (M13.003)	12560336,
PREP_HUMAN	238	VVTR.\|.RSQE	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	239	VTRS.\|.SQED	inferred from experiment	unknown	MEROPS	Devi LA	Mzhavia N et al.:Cloning, expression, and charac... (M16.009)	10360838,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)