O14773: Tripeptidyl-peptidase 1

General Information

Protein names	- Tripeptidyl-peptidase 1 - TPP-1 - 3.4.14.9 {ECO:0000269\|PubMed:11054422, ECO:0000269\|PubMed:19038966, ECO:0000269\|PubMed:19038967} - Cell growth-inhibiting gene 1 protein - Lysosomal pepstatin-insensitive protease - LPIC - Tripeptidyl aminopeptidase - Tripeptidyl-peptidase I - TPP-I
Gene names	TPP1
Organism	Homo sapiens
Protease Family	S53.003
Protease ID	S53.003
Chromosome location
UniProt ID	O14773

19 N-termini

9 C-termini

8 Cleavages

30 Substrates

Sequence

        10         20         30         40         50         60
MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNVER
        70         80         90        100        110        120
LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLHTVQ KWLLAAGAQK CHSVITQDFL
       130        140        150        160        170        180
TCWLSIRQAE LLLPGAEFHH YVGGPTETHV VRSPHPYQLP QALAPHVDFV GGLHRFPPTS
       190        200        210        220        230        240
SLRQRPEPQV TGTVGLHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL
       250        260        270        280        290        300
AQFMRLFGGN FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG
       310        320        330        340        350        360
QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR GLTLLFASGD
       370        380        390        400        410        420
SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS
       430        440        450        460        470        480
YQEEAVTKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV
       490        500        510        520        530        540
FGGILSLINE HRILSGRPPL GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP
       550        560
GWDPVTGWGT PNFPALLKTL LNP

Isoforms

- Isoform 2 of Tripeptidyl-peptidase 1

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14773-20-	SYSPEP...	20		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O14773-20-	SYSPEP...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O14773-20-	SYSPEP...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14773-20-	SYSPEP...	20		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14773-20-	SYSPEP...	20		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O14773-98-unknown	TVQKWL...	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31879
O14773-169-unknown	FVGGLH...	169	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31880
O14773-172-unknown	GLHRFP...	172	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31881
O14773-175-unknown	RFPPTS...	175	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31882
O14773-182-unknown	LRQRPE...	182	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31883
O14773-190-unknown	VTGTVG...	190	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31884
O14773-191-	TGTVGL...	191		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14773-193-unknown	TVGLHL...	193	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31885
O14773-195-unknown	GLHLGV...	195		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14773-195-unknown	GLHLGV...	195		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14773-195-	GLHLGV...	195		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O14773-195-	GLHLGV...	195		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O14773-195-	GLHLGV...	195		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14773-196-unknown	LHLGVT...	196	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14773-196-unknown	LHLGVT...	196	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31886
O14773-196-unknown	LHLGVT...	196		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14773-196-unknown	LHLGVT...	196		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14773-196-	LHLGVT...	196		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O14773-196-	LHLGVT...	196		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O14773-196-	LHLGVT...	196		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O14773-196-	LHLGVT...	196		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14773-196-	LHLGVT...	196		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14773-196-	LHLGVT...	196		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O14773-197-	HLGVTP...	197		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O14773-197-	HLGVTP...	197		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O14773-197-	HLGVTP...	197		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O14773-244-unknown	MRLFGG...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92881
O14773-316-unknown	ALPHVH...	316	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177355
O14773-316-	ALPHVH...	316		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O14773-512-	GAGLFD...	512		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O14773-512-unknown	GAGLFD...	512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177926

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLTLHT	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31879
...APHVDF	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31880
...VDFVGG	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31881
...VGGLHR	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31882
...PPTSSL	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31883
...RPEPQV	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31884
...PQVTGT	192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31885
...TGTVGL	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31886
...TLLNP	563	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TLLNP	563	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88499

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TPP1_HUMAN	97	TLHT.\|.TVQK	inferred from experiment	unknown	MEROPS	Kida E	Golabek AA et al.:Maturation of human tripeptidyl... (S53.003)	15143070,
TPP1_HUMAN	168	HVDF.\|.FVGG	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	171	FVGG.\|.GLHR	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	174	GLHR.\|.RFPP	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	181	TSSL.\|.LRQR	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	189	EPQV.\|.VTGT	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	192	VTGT.\|.TVGL	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	195	TVGL.\|.LHLG	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_HUMAN	36	DRVY.\|.YIHP	inferred from experiment	unknown	MEROPS	Ohkubo I	Du PG et al.:Rat tripeptidyl peptidase I: mo... (S53.003)	11843185,
ANGT_HUMAN	37	RVYI.\|.IHPF	inferred from experiment	unknown	MEROPS		Merops TPP1_HUMAN -> ANGT_HUMAN @37
ANGT_HUMAN	40	IHPF.\|.FHLV	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
NMB_HUMAN	49	GNLW.\|.WATG	inferred from experiment	unknown	MEROPS	Ohkubo I	Du PG et al.:Rat tripeptidyl peptidase I: mo... (S53.003)	11843185,
NMB-Isoform2_HUMAN	49	GNLW.\|.WATG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31906
GLUC_HUMAN	55	HSQG.\|.GTFT	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	58	GTFT.\|.TSDY	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	61	TSDY.\|.YSKY	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	64	YSKY.\|.YLDS	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	67	YLDS.\|.SRRA	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	70	SRRA.\|.AQDF	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	73	AQDF.\|.FVQW	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	76	FVQW.\|.WLMN	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
GLUC_HUMAN	79	WLMN.\|.NTKR	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	97	TLHT.\|.TVQK	inferred from experiment	unknown	MEROPS	Kida E	Golabek AA et al.:Maturation of human tripeptidyl... (S53.003)	15143070,
CCKN_HUMAN	101	GWMD.\|.DFGR	inferred from experiment	unknown	MEROPS	Warburton MJ	Bernardini F et al.:Lysosomal degradation of cholec... (C01.070)	12038963,
NEUT_HUMAN	153	QLYE.\|.ENKP	inferred from experiment	unknown	MEROPS	Ohkubo I	Du PG et al.:Rat tripeptidyl peptidase I: mo... (S53.003)	11843185,
TPP1_HUMAN	168	HVDF.\|.FVGG	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	171	FVGG.\|.GLHR	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	174	GLHR.\|.RFPP	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
PDYN_HUMAN	177	YGGF.\|.FLRK	inferred from experiment	unknown	MEROPS	Ohkubo I	Du PG et al.:Rat tripeptidyl peptidase I: mo... (S53.003)	11843185,
TPP1_HUMAN	181	TSSL.\|.LRQR	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	189	EPQV.\|.VTGT	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	192	VTGT.\|.TVGL	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
TPP1_HUMAN	195	TVGL.\|.LHLG	inferred from experiment	unknown	MEROPS	Lobel P	Guhaniyogi J et al.:Crystal structure and autoactiv... (S53.003)	19038967,
PDYN_HUMAN	209	YGGF.\|.FLRR	inferred from experiment	unknown	MEROPS	Oda K	Oyama H et al.:Catalytic residues and substrat... (S53.003)	16091586,
COLI_HUMAN	239	YGGF.\|.FMTS	inferred from experiment	unknown	MEROPS	Oda K	Oyama H et al.:Catalytic residues and substrat... (S53.003)	16091586,
KNG1-Isoform3_HUMAN	347	RPPG.\|.GFSP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31890
KNG1_HUMAN	383	RPPG.\|.GFSP	inferred from experiment	unknown	MEROPS	Oda K	Oyama H et al.:Catalytic residues and substrat... (S53.003)	16091586,
KNG1-Isoform2_HUMAN	383	RPPG.\|.GFSP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31890

TopFIND

O14773: Tripeptidyl-peptidase 1

General Information

19

N-termini

9

C-termini

8

Cleavages

30

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

19 N-termini - 9 C-termini - 8 Cleavages - 30 Substrates

N-termini

C-termini

Cleavages

Substrates