TopFIND 4.0

P06307: Cholecystokinin

General Information

Protein names	- Cholecystokinin - CCK - Cholecystokinin-58 - CCK58 - Cholecystokinin-58 desnonopeptide - (1-49)-CCK58 - Cholecystokinin-39 - CCK39 - Cholecystokinin-33 - CCK33 - Cholecystokinin-25 - CCK25 - Cholecystokinin-18 - CCK18 - Cholecystokinin-12 - CCK12 - Cholecystokinin-8 - CCK8 - Cholecystokinin-7 - CCK7 - Cholecystokinin-5 - CCK5
Gene names	CCK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06307

10

N-termini

10

C-termini

16

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT DGESRAHLGA
70 80 90 100 110
LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 10 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06307-21-unknown	QPVPPA...	21		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06307-97-unknown	YMGWMD...	97		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC235
P06307-99-unknown	GWMDFG...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31910
P06307-100-unknown	WMDFGR...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19924
P06307-101-unknown	MDFGRR...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18500
P06307-101-unknown	MDFGRR...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26725
P06307-101-unknown	MDFGRR...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4311
P06307-101-unknown	MDFGRR...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17130
P06307-102-unknown	DFGRRS...	102		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31905
P06307-102-unknown	DFGRRS...	102		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17131
P06307-103-unknown	FGRRSA...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26726
P06307-103-unknown	FGRRSA...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17132
P06307-104-unknown	GRRSAE...	104		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC927
P06307-104-unknown	GRRSAE...	104		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC727
P06307-104-unknown	GRRSAE...	104		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06307-104-unknown	GRRSAE...	104		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P06307-105-unknown	RRSAEE...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC38
P06307-105-unknown	RRSAEE...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8303
P06307-106-unknown	RSAEEY...	106		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8304

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...ISDRDY	96	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC235
	...DRDYMG	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31910
	...RDYMGW	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19924
	...DYMGWM	100	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18500
	...DYMGWM	100	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26725
	...DYMGWM	100	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4311
	...DYMGWM	100	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17130
	...YMGWMD	101	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31905
	...YMGWMD	101	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17131
	...MGWMDF	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26726
	...MGWMDF	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17132
	...GWMDFG	103	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC927
	...GWMDFG	103	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC727
	...WMDFGR	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC38
	...WMDFGR	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8303
	...MDFGRR	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8304
	...YEYPS	115	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
AMPE_HUMAN	96	DRDY.\|.YMGW	inferred from experiment	unknown	MEROPS	Roques BP	Migaud M et al.:The in vivo metabolism of chole... (M01.003)	8804068,
TPP2_HUMAN	98	DYMG.\|.GWMD	inferred from experiment	unknown	MEROPS	McDermott JR	Wilson C et al.:Purification and characterizati... (S08.090)	8396212,
MMEL1_HUMAN	99	YMGW.\|.WMDF	inferred from experiment	unknown	MEROPS	Ouimet T	Rose C et al.:Cell-specific activity of nepri... (M13.008)	11964170,
MEP1B_HUMAN	100	MGWM.\|.MDFG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
NEP_HUMAN	100	MGWM.\|.MDFG	inferred from experiment	unknown	MEROPS		Merops NEP_HUMAN -> CCKN_HUMAN @100
CATC_HUMAN	100	MGWM.\|.MDFG	inferred from experiment	unknown	MEROPS	Warburton MJ	Bernardini F et al.:Lysosomal degradation of cholec... (C01.070)	12038963,
MEP1A_HUMAN	100	MGWM.\|.MDFG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
TPP1_HUMAN	101	GWMD.\|.DFGR	inferred from experiment	unknown	MEROPS	Warburton MJ	Bernardini F et al.:Lysosomal degradation of cholec... (C01.070)	12038963,
MEP1A_HUMAN	101	GWMD.\|.DFGR	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
NEP_HUMAN	102	WMDF.\|.FGRR	inferred from experiment	unknown	MEROPS		Merops NEP_HUMAN -> CCKN_HUMAN @102
MEP1A_HUMAN	102	WMDF.\|.FGRR	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
CAN2_HUMAN	103	MDFG.\|.GRRS	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
CAN1_HUMAN	103	MDFG.\|.GRRS	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
ACE_HUMAN	104	DFGR.\|.RRSA	inferred from experiment	unknown	MEROPS	Coates D	Isaac RE et al.:Cleavage of arginyl-arginine an... (M02.001)	9371719,
CBPE_HUMAN	104	DFGR.\|.RRSA	inferred from experiment	unknown	MEROPS	Beinfeld MC	Beinfeld MC et al.:Biosynthesis and processing of ... (M14.005)	12479974,
CBPE_HUMAN	105	FGRR.\|.RSAE	inferred from experiment	unknown	MEROPS	Beinfeld MC	Beinfeld MC et al.:Biosynthesis and processing of ... (M14.005)	12479974,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)